{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T22:51:40Z","timestamp":1790635900357,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,12,28]],"date-time":"2016-12-28T00:00:00Z","timestamp":1482883200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Lower Saxony ministry of Science and Research"},{"name":"The VolkswagenStiftung"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Engineering in Life Sciences"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:p>Cardiovascular disease is the most common cause of death, accounting for 31% of deaths worldwide. As purely synthetic grafts implicate concomitant anticoagulation and autologous veins are rare, tissue\u2010engineered vascular grafts are urgently needed. For successful in vitro cultivation of a bioartificial vascular graft, the suitable bioreactor should provide conditions comparable to vasculogenesis in the body. Such a system has been developed and characterized under continuous and pulsatile flow, and a variety of sensors has been integrated into the bioreactor to control parameters such as temperature, pressure up to 500\u00a0mbar, glucose up to 4.5 g\/L, lactate, oxygen up to 150\u00a0mbar, and flow rate. Wireless data transfer (using the ZigBee specification based on the IEEE 802.15.4 standard) and multiple corresponding sensor signal processing platforms have been implemented as well. Ultrasound is used for touchless monitoring of the growing vascular structure as a quality control before implantation (maximally achieved ultrasound resolution 65\u00a0\u03bcm at 15\u00a0MHz). To withstand the harsh conditions of steam sterilization (120\u00b0C for 20 min), all electronics were encapsulated. With such a comprehensive physiologically conditioning, sensing, and imaging bioreactor system, all the requirements for a successful cultivation of vascular grafts are available now.<\/jats:p>","DOI":"10.1002\/elsc.201600138","type":"journal-article","created":{"date-parts":[[2016,12,6]],"date-time":"2016-12-06T01:22:42Z","timestamp":1480987362000},"page":"567-578","source":"Crossref","is-referenced-by-count":24,"title":["An intelligent bioreactor system for the cultivation of a bioartificial vascular graft"],"prefix":"10.1002","volume":"17","author":[{"given":"Paul","family":"Maschhoff","sequence":"first","affiliation":[{"name":"Institute of Technical Chemistry Leibniz University Hannover  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Heene","sequence":"additional","affiliation":[{"name":"Institute of Technical Chemistry Leibniz University Hannover  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonina","family":"Lavrentieva","sequence":"additional","affiliation":[{"name":"Institute of Technical Chemistry Leibniz University Hannover  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thorleif","family":"Hentrop","sequence":"additional","affiliation":[{"name":"Institute of Technical Chemistry Leibniz University Hannover  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Leibold","sequence":"additional","affiliation":[{"name":"Institute for Microelectronic Systems Leibniz University Hannover  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc\u2010Nils","family":"Wahalla","sequence":"additional","affiliation":[{"name":"Institute for Microelectronic Systems Leibniz University Hannover  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nils","family":"Stanislawski","sequence":"additional","affiliation":[{"name":"Institute of Technical Chemistry Leibniz University Hannover  Germany"},{"name":"Institute for Microelectronic Systems Leibniz University Hannover  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holger","family":"Blume","sequence":"additional","affiliation":[{"name":"Institute for Microelectronic Systems Leibniz University Hannover  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Scheper","sequence":"additional","affiliation":[{"name":"Institute of Technical Chemistry Leibniz University Hannover  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelia","family":"Blume","sequence":"additional","affiliation":[{"name":"Institute of Technical Chemistry Leibniz University Hannover  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,12,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2016.09.026"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.34872"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.2217\/rme.09.77"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-013-1546-3"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2008.0499"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2010.09.019"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10439-013-0823-5"},{"key":"e_1_2_8_9_1","volume-title":"Proceedings of the Second Joint EMBOLisMS Conference","author":"Tsikli S."},{"key":"e_1_2_8_10_1","unstructured":"Mansouri W. Rindone A. N. D. Jr.Cooper J. A. Development and characterization of a pulsatile\u2010flow bioreactor for vascular graft studies; 978\u20101\u20104799\u20108360\u20105\/15\/2015 IEEE."},{"key":"e_1_2_8_11_1","doi-asserted-by":"crossref","unstructured":"Dutta D. Lee K. W. Allen R. Yu J.et\u00a0al. Noninvasive assessment of mechanical property changes with cell growth in a polymer\u2010based vascular graft using IEEE 2011 abstract 987 1457712524.","DOI":"10.1109\/ULTSYM.2011.0557"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tec.2015.0110"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.4236\/eng.2013.510B080"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/153857440303700107"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0377-0257(87)87007-6"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0141-3910(97)00180-8"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/02652038709373610"},{"key":"e_1_2_8_18_1","first-page":"651","article-title":"Medium with blood\u2010analog mechanical properties for cardiovascular tissue culturing","volume":"45","author":"den Broek C. N.","year":"2008","journal-title":"Biorheology"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00164414"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-013-1597-7"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/hpt233"},{"key":"e_1_2_8_22_1","volume-title":"An Introduction to Chemical Engineering Kinetics & Reactor Design","author":"Hill C. G.","year":"1977"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2014.02.026"},{"key":"e_1_2_8_24_1","doi-asserted-by":"crossref","unstructured":"Leibold C. Kornau N. Wilhelmi M. Blume C.et\u00a0al. An electronic encapsulated Monitoring System for a Vascular Graft Bioreactor Biomedical Circuits and Systems Conference (BioCAS 2015) 2015.","DOI":"10.1109\/BioCAS.2015.7348338"},{"key":"e_1_2_8_25_1","doi-asserted-by":"crossref","unstructured":"Leibold C. Wahalla M. Blume C. Blume H. Wilhelmi M. \u201cA real\u2010time monitoring system controller for medical tissue engineering bioreactors \u201d In: IEEE International Conference on Consumer Electronics (ICCE) January 2015. Las Vegas Nevada 2015 pp. 40\u201341.","DOI":"10.1109\/ICCE.2015.7066310"},{"key":"e_1_2_8_26_1","doi-asserted-by":"crossref","unstructured":"Leibold C. Wilkening J. Blume C. Blume H. A Toolchain for the 3D\u2010Visualization of Bioartificial Vascular Grafts based on Ultrasound Images Biomedical Circuits and Systems Conference (BioCAS 2016) 2016.","DOI":"10.1109\/BioCAS.2016.7833738"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.3233\/BIR-1983-20603"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.3233\/BIR-1990-27508"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.3233\/BIR-1993-30202"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9290(99)00014-7"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00284-005-0225-5"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.4155\/pbp.14.13"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2014.10.076"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1364\/BOE.2.002982"}],"container-title":["Engineering in Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Felsc.201600138","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Felsc.201600138","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/elsc.201600138","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T14:42:54Z","timestamp":1760539374000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/elsc.201600138"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,28]]},"references-count":33,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,5]]}},"alternative-id":["10.1002\/elsc.201600138"],"URL":"https:\/\/doi.org\/10.1002\/elsc.201600138","archive":["Portico"],"relation":{},"ISSN":["1618-0240","1618-2863"],"issn-type":[{"value":"1618-0240","type":"print"},{"value":"1618-2863","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,28]]}}}