{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T06:53:10Z","timestamp":1777531990557,"version":"3.51.4"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2003,1,27]],"date-time":"2003-01-27T00:00:00Z","timestamp":1043625600000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Swedish Cancer Society","award":["3965-B00-04XBC"],"award-info":[{"award-number":["3965-B00-04XBC"]}]},{"name":"Swedish Match Medical Research Foundation","award":["200107"],"award-info":[{"award-number":["200107"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Environ and Mol Mutagen"],"published-print":{"date-parts":[[2003,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The DNA repair proteins XPD and XRCC1 are involved in the nucleotide and base excision repair of DNA lesions induced by many tobacco and environmental carcinogens. Common variant alleles at the <jats:italic>XPD<\/jats:italic> (312Asn, 751Gln) and <jats:italic>XRCC1<\/jats:italic> (399Gln) loci have been identified and associated with increased risk for lung cancer. We therefore investigated a possible effect of these variant alleles on the frequency and spectrum of <jats:italic>p53<\/jats:italic> mutations in the tumors of 97 Swedish lung cancer patients (56 never\u2010smokers and 41 age\u2010, gender\u2010, and hospital\u2010matched ever\u2010smokers). The <jats:italic>p53<\/jats:italic> gene was mutated in 4 never\u2010smokers (7%) and 11 ever\u2010smokers (27%). Smoking\u2010related transversion\u2010type mutations predominated over transitions among smokers (8:3), but not among never\u2010smokers (1:3). None of the variant alleles altered the overall frequency of <jats:italic>p53<\/jats:italic> mutation. Transversions, however, were marginally increased among patients with at least one <jats:italic>XPD<\/jats:italic> variant allele compared with patients who were wild\u2010type homozygotes (73% vs. 25% for the Asp312Asn polymorphism, <jats:italic>P<\/jats:italic> = 0.095; 78% vs. 33% for Lys751Gln, <jats:italic>P<\/jats:italic> = 0.085). Five of six women or six of seven smokers who carried at least one <jats:italic>XPD<\/jats:italic> 751Gln allele had <jats:italic>p53<\/jats:italic> transversion. The <jats:italic>XRCC1<\/jats:italic> variant allele did not show any effect on the <jats:italic>p53<\/jats:italic> mutation. We conclude that the <jats:italic>XPD<\/jats:italic> variant alleles may be associated with an increased frequency of smoking\u2010related <jats:italic>p53<\/jats:italic> mutations in lung tumors, presumably due to reduced DNA repair proficiency. Environ. Mol. Mutagen. 41:37\u201342, 2003. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/em.10128","type":"journal-article","created":{"date-parts":[[2003,1,28]],"date-time":"2003-01-28T15:41:17Z","timestamp":1043768477000},"page":"37-42","source":"Crossref","is-referenced-by-count":29,"title":["Influence of common <i>XPD<\/i> and <i>XRCC1<\/i> variant alleles on <i>p53<\/i> mutations in lung tumors"],"prefix":"10.1002","volume":"41","author":[{"given":"Sai\u2010Mei","family":"Hou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotta","family":"Ryk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annamaria","family":"Kannio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabrina","family":"Angelini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susann","family":"F\u00e4lt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fredrik","family":"Nyberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirsti","family":"Husgafvel\u2010Pursiainen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2003,1,27]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/22.4.593"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-5002(01)00256-2"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.274.5286.430"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0921-8777(00)00059-8"},{"key":"e_1_2_1_6_1","first-page":"77","article-title":"Polymorphisms 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