{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T20:40:03Z","timestamp":1700253603499},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2003,1,27]],"date-time":"2003-01-27T00:00:00Z","timestamp":1043625600000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Environ and Mol Mutagen"],"published-print":{"date-parts":[[2003,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>1\u2010Methyl\u20104\u2010phenyl\u20101,2,3,6\u2010tetrahydropyridine (MPTP) is a neurotoxin that induces Parkinsonism in humans, monkeys, and mice and oxidative stress in mammalian cells and tissues. In the present study, the relationship between the generation of lipid peroxidation products and DNA damage was studied in mice treated with MPTP. The frequency of micronucleated polychromatic erythrocytes (MN\u2010PCE) and the concentrations of malonaldehyde and 4\u2010hydroxyalkenals were determined in the bone marrow and peripheral blood of mice 0, 24, 48, 72, and 96 hr after treatment with MPTP, cyclophosphamide as a positive control, or diluent. Both MN\u2010PCE and the lipid peroxidation products increased in MPTP\u2010treated mice, with significant levels being detected in bone marrow starting at 24 hr after treatment and in blood starting at 48 hr after treatment. These results suggest that the generation of oxidative products is related to the DNA damage produced by MPTP in mice. Environ. Mol. Mutagen. 41:64\u201368, 2003. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/em.10133","type":"journal-article","created":{"date-parts":[[2003,1,28]],"date-time":"2003-01-28T15:41:17Z","timestamp":1043768477000},"page":"64-68","source":"Crossref","is-referenced-by-count":5,"title":["1\u2010Methyl\u20104\u2010phenyl\u20101,2,3,6\u2010tetrahydropyridine\u2013induced lipid peroxidation and DNA damage in mouse bone marrow and blood"],"prefix":"10.1002","volume":"41","author":[{"given":"Genaro G.","family":"Ortiz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillermo","family":"Z\u00fa\u00f1iga\u2010Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joaqu\u00edn 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