{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T15:12:54Z","timestamp":1764688374310},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,1,16]],"date-time":"2004-01-16T00:00:00Z","timestamp":1074211200000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Environ and Mol Mutagen"],"published-print":{"date-parts":[[2004,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Exposure to <jats:italic>N<\/jats:italic>\u2010nitroso compounds is thought to play a key role in the development of gastric cancer in humans. The alkylating agent <jats:italic>N<\/jats:italic>\u2010methyl\u2010<jats:italic>N<\/jats:italic>\u2032\u2010nitrosoguanidine (MNNG) is carcinogenic in a number of animal models and its preferential target tissue is the gastrointestinal (GI) tract. The genetic synteny among rats and humans makes the rat a useful model for induced tumorigenesis. However, because of the limited availability of genetic information, cytogenetic and molecular studies are rarely performed in the rat. We report an investigation of eight MNNG\u2010induced rat gastric tumors by comparative genomic hybridization (CGH). The tumors were from forestomach (induced by a single dose of MNNG) and from pylorus (induced by chronic exposure). CGH identified a genetic fingerprint of chromosomal imbalances common to the two types of the tumors. Frequent gains were observed at 9q11\u2013q12, 15q22\u201325, and Xq11\u2013q12. Forestomach carcinomas were also characterized by gains in 7q11\u2013q12, 20q13, and Yq12. Homology studies between the rat and human genomes indicate the presence of genes within these regions with potential relevance to tumorigenesis in the GI tract. Our findings provide new insights into the location of genes involved in MNNG\u2010induced gastric cancer initiation and\/or progression in the rat. Environ. Mol. Mutagen. 43:20\u201327, 2004. \u00a9 2004 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/em.10211","type":"journal-article","created":{"date-parts":[[2004,1,21]],"date-time":"2004-01-21T09:00:49Z","timestamp":1074675649000},"page":"20-27","source":"Crossref","is-referenced-by-count":4,"title":["Comparative genomic hybridization analysis of <i>N<\/i>\u2010methyl\u2010<i>N<\/i>\u2032\u2010nitrosoguanidine\u2010induced rat gastrointestinal tumors discloses a cytogenetic fingerprint"],"prefix":"10.1002","volume":"43","author":[{"given":"Chiara","family":"Corso","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James M.","family":"Parry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,1,16]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s003359900750"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1827.2002.01365.x"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-4608(98)00023-5"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0027-5107(02)00157-4"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-4608(02)00562-9"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/1098-2264(2000)9999:9999<000::AID-GCC1000>3.0.CO;2-0"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-1218(97)00052-9"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00525293"},{"key":"e_1_2_1_10_1","first-page":"740","article-title":"Nonrandom chromosome alterations that correlate with progression to immortality in rat tracheal epithelial cells transformed with N\u2010methyl\u2010N\u2032\u2010nitro\u2010N\u2010nitrosoguanidine","volume":"50","author":"Endo S","year":"1990","journal-title":"Cancer Res"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/08977190290022194"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000015034"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1359641"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.2870100403"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/23.10.1729"},{"key":"e_1_2_1_16_1","first-page":"1575","article-title":"Analysis of chromosome 17p13 (p53 locus) alterations in gastric carcinoma cells by dual\u2010color fluorescence in situ hybridization","volume":"149","author":"Kobayashi M","year":"1996","journal-title":"Am J Pathol"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1026795717658"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1159\/000015032"},{"key":"e_1_2_1_19_1","first-page":"629","article-title":"The etiology of gastric cancer. 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