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Six (12%) of these patients exhibited a total of eight different novel germ\u2010line mutations that do not represent common polymorphisms. Of these, three patients possessed four nonconservative missense mutations while two conservative missense and two synonymous mutations were detected in the other three patients. In addition, 43 patients were found to have a total of 141 DNA sequence variations representing 21 different common polymorphisms and rare variants. An analysis of the relationship between the presence of a novel <jats:italic>ATM<\/jats:italic> mutation and either patient demographics or tumor properties demonstrated a significant difference between African Americans (3\/7 = 43%) and other ethnic groups (3\/45 = 7%, <jats:italic>P<\/jats:italic> = 0.026). None of the other characteristics examined was found to be related to mutation status. Environ. Mol. 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