{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T12:29:52Z","timestamp":1773664192985,"version":"3.50.1"},"reference-count":53,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,6,21]],"date-time":"2005-06-21T00:00:00Z","timestamp":1119312000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Environ and Mol Mutagen"],"published-print":{"date-parts":[[2005,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We evaluated the influence of several DNA repair gene polymorphisms on the frequency of chromosomal aberrations (CAs) analyzed in peripheral lymphocytes, using the fluorescence in situ hybridization technique. The CA data were obtained from an earlier study of 84 healthy nonsmokers (48 women and 36 men) carefully characterized for indoor radon exposure. The frequency of translocations showed a wide interindividual variability, which was only partly explained by age. To investigate the potential role of DNA repair polymorphisms in this variation, genotypes of DNA repair genes<jats:italic>OGG1<\/jats:italic>(codon 326),<jats:italic>XPD<\/jats:italic>(codon 751),<jats:italic>XRCC1<\/jats:italic>(X\u2010ray repair cross\u2010complementing group 1) (codons 194, 280, and 399), and<jats:italic>XRCC3<\/jats:italic>(X\u2010ray repair cross\u2010complementing group 3) (codon 241) were determined from leukocyte DNA using polymerase chain reaction\u2010based methods. Negative binomial regression models were applied to evaluate the effect of the polymorphisms and other factors (age, gender, radon exposure, and medical exposure) on the frequency of CAs. No interactions between genotypes and radon, medical exposure, or gender were found. Carriers of the<jats:italic>XRCC1<\/jats:italic>codon 280His variant allele had a two\u2010fold increase (frequency ratio [FR] = 2.01, 95% confidence interval [CI] = 1.01\u20133.98;<jats:italic>P<\/jats:italic>= 0.046) in unstable exchanges (dicentrics and ring chromosomes). In addition, the<jats:italic>XRCC3<\/jats:italic>codon 241 homozygous variant genotype (Met\/Met) was associated with an increase (FR = 1.70, 95% CI = 1.06\u20132.74;<jats:italic>P<\/jats:italic>= 0.028) in two\u2010way translocations when age was taken into account in the analysis. Our data suggest that the<jats:italic>XRCC1<\/jats:italic>280His and<jats:italic>XRCC3<\/jats:italic>241Met alleles affect individual CA levels, most probably via influencing the DNA repair phenotype. Environ. Mol. Mutagen. 46:000\u2013000, 2005. \u00a9 2005 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/em.20155","type":"journal-article","created":{"date-parts":[[2005,6,21]],"date-time":"2005-06-21T20:51:08Z","timestamp":1119387068000},"page":"198-205","source":"Crossref","is-referenced-by-count":42,"title":["Influence of DNA repair gene polymorphisms on the yield of chromosomal 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