{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T22:28:49Z","timestamp":1759530529112},"reference-count":52,"publisher":"Wiley","issue":"3-4","license":[{"start":{"date-parts":[[2007,3,14]],"date-time":"2007-03-14T00:00:00Z","timestamp":1173830400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Environ and Mol Mutagen"],"published-print":{"date-parts":[[2007,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The prophylactic use of zidovudine (3\u2032\u2010azido\u20103\u2032\u2010deoxythymidine, AZT) during pregnancy greatly reduces transmission of HIV\u20101 from infected mothers to their infants; however, the affinity of host cell DNA polymerases for AZT also allows for its incorporation into host cell DNA, predisposing to cancer development. To expand upon previous transplacental carcinogenesis assays performed in CD\u20101 mice, the transplacental carcinogenicity of AZT was evaluated in a second mouse strain and a second rodent species. Date\u2010mated female mice and rats were gavaged daily with 0, 80, 240, or 480 mg AZT\/kg bw during the last 7 days of gestation. At 2 years postpartum, male and female B6C3F1 mouse and F344 rat offspring (<jats:italic>n<\/jats:italic> = 44\u201346 of each sex and species\/treatment group) were necropsied for gross and microscopic tissue examinations. Under the conditions of these two\u2010year studies, there was clear evidence of carcinogenic activity based upon significant dose\u2010related trends and increases in the incidences of hemangiosarcoma in male mice and mononuclear cell leukemia in female rats. There was some evidence of carcinogenic activity in the livers of male mice based upon a positive trend and an increased incidence of hepatic carcinoma in the high\u2010dose AZT group. The incidence of gliomas in female rats exceeded the historical background rates for gliomas in F344 rats. P53 overexpression was detected in some AZT\u2010treated mouse neoplasms. These and other cancer\u2010related findings confirm and extend those of previous transplacental carcinogenicity studies of AZT in mice, support the need for long\u2010term follow\u2010up of nucleoside reverse transcriptase inhibitor (NRTI)\u2010exposed children, and indicate the necessity for effective protective strategies against NRTI\u2010induced side effects. Environ. Mol. Mutagen., 2007. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/em.20297","type":"journal-article","created":{"date-parts":[[2007,3,15]],"date-time":"2007-03-15T02:21:42Z","timestamp":1173925302000},"page":"283-298","source":"Crossref","is-referenced-by-count":28,"title":["Transplacental carcinogenicity of 3\u2032\u2010azido\u20103\u2032\u2010deoxythymidine in B6C3F1 mice and F344 rats"],"prefix":"10.1002","volume":"48","author":[{"given":"Dale M.","family":"Walker","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David E.","family":"Malarkey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven K.","family":"Seilkop","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederick A.","family":"Ruecker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathleen 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