{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T07:46:56Z","timestamp":1792741616344,"version":"4.5.0"},"reference-count":52,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2007,6,21]],"date-time":"2007-06-21T00:00:00Z","timestamp":1182384000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Environ and Mol Mutagen"],"published-print":{"date-parts":[[2007,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Epidemiological studies show that benzene exposure is associated with an increased incidence of leukemia and perhaps lymphoma. Chromosomal rearrangements are common in these hematopoietic diseases. Translocation t(14;18), the long\u2010arm deletion of chromosome 6 [del(6q)], and trisomy 12 are frequently observed in lymphoma patients. Rearrangements of the <jats:italic>MLL<\/jats:italic> gene located on chromosome 11q23, such as t(4;11) and t(6;11), are common in therapy\u2010related leukemias resulting from treatment with topoisomerase II inhibiting drugs. To examine numerical and structural changes in these chromosomes (2, 4, 6, 11, 12, 14, and 18), fluorescence in situ hybridization (FISH) was employed on metaphase spreads from workers exposed to benzene (<jats:italic>n<\/jats:italic> = 43) and matched controls (<jats:italic>n<\/jats:italic> = 44) from Shanghai, China. Aneuploidy (both monosomy and trisomy) of all seven chromosomes was increased by benzene exposure. Benzene also induced del(6q) in a dose\u2010dependent manner (<jats:italic>P<\/jats:italic><jats:sub>trend<\/jats:sub> = 0.0002). Interestingly, translocations between chromosomes 14 and 18, t(14;18), known to be associated with follicular non\u2010Hodgkin lymphoma, were increased in the highly exposed workers (<jats:italic>P<\/jats:italic> &lt; 0.001). On the other hand, translocations between chromosome 11 and other partner chromosomes that are found in therapy\u2010induced leukemias were not increased. These data add weight to the notion that benzene can induce t(14;18) and del(6q) found in lymphoma, but do not support the idea that benzene induces t(4;11) or t(6;11). However, they do not rule out the possibility that other rearrangements of the <jats:italic>MLL<\/jats:italic> gene at chromosome 11q23 may be induced by benzene. Environ. Mol. Mutagen., 2007. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/em.20306","type":"journal-article","created":{"date-parts":[[2007,6,21]],"date-time":"2007-06-21T19:47:13Z","timestamp":1182455233000},"page":"467-474","source":"Crossref","is-referenced-by-count":51,"title":["Aberrations in chromosomes associated with lymphoma and therapy\u2010related leukemia in benzene\u2010exposed 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