{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T10:15:26Z","timestamp":1778926526623,"version":"3.51.4"},"reference-count":47,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2008,6,5]],"date-time":"2008-06-05T00:00:00Z","timestamp":1212624000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Environ and Mol Mutagen"],"published-print":{"date-parts":[[2008,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The genotoxic activity of surface water samples from four sites along the Paraguay River, near C\u00e1ceres, Mato Grosso State, Brazil, was investigated using the <jats:italic>Drosophila melanogaster<\/jats:italic> Somatic Mutation and Recombination test (SMART). Effluents from sanitary sewers and agroindustrial effluents (residual effluents from slaughterhouses, leather tanneries, and dairies) flow into the Paraguay River, and directly or indirectly contaminate water from sampling sites 1\u20133. Site 4 was an upriver reference site that received no domestic or agroindustrial discharges. Water was collected at 4 time periods: September 2003 and August 2004 (periods of low water or drought); and April 2004 and March 2005 (periods of high water or flood). Chromium concentrations above statutory limits were detected at sites 1\u20133 (August 2004), and sites 1, 2 and 4 (March 2005). Sulfur compounds were also detected at sites 1\u20133. The SMART performed using standard (ST) cross flies detected genotoxic responses in only two samples, the August 2004 site 1 sample and the March 2005 site 2 sample. Many more samples were positive using high bioactivation (HB) cross flies: site 1 (all collection periods), site 2 (September 2003 and April 2004), and site 3 (September 2003 and August 2004). Mutant frequency comparisons between marker\u2010heterozygous and balancer\u2010heterozygous flies from the HB cross indicated that the positive genotoxic responses for the site 2 (April 2004) and site 3 (September 2003) samples were due mainly to mitotic recombination. Our findings indicate that the section of the Paraguay River within the urban perimeter of C\u00e1ceres is contaminated with genotoxic agents. Environ. Mol. Mutagen., 2008. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/em.20404","type":"journal-article","created":{"date-parts":[[2008,6,5]],"date-time":"2008-06-05T21:46:19Z","timestamp":1212702379000},"page":"458-466","source":"Crossref","is-referenced-by-count":9,"title":["Genotoxicity of water from the Paraguay River near C\u00e1ceres\u2013MT, Brazil in the Drosophila wing\u2010spot test"],"prefix":"10.1002","volume":"49","author":[{"given":"V\u00e2nia Maria Sartini Dutra","family":"Pimenta","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00falio C\u00e9sar","family":"Nepomuceno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luiz Alfredo","family":"Pavanin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,6,5]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"359","article-title":"Limnological characteristics of the water bodies of the corutuba nesting site in Brazil's Pantanal","volume":"16","author":"Abdo MSA","year":"2004","journal-title":"Acta Limnologia Brasiliensia"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrgentox.2005.02.002"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2005.06.004"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1040-6182(03)00039-9"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquatox.2005.06.001"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1383-5742(98)00008-8"},{"key":"e_1_2_1_8_1","first-page":"1235","volume-title":"Standard Methods for Examination of Water & Wastewater","author":"Clescerl LS","year":"1999"},{"key":"e_1_2_1_9_1","unstructured":"CONAMA.2005. Resolu\u00e7\u00e3o No357 de 17 de mar\u00e7o de 2005. Conselho Nacional de meio Ambiente. Available at:http:\/\/www.mma.gov.br\/port\/conama\/res\/res05\/res35705.pdf[accessed 10 May 2006]."},{"key":"e_1_2_1_10_1","first-page":"97","volume-title":"New Approaches to River Management","author":"Da Silva CJ","year":"2000"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1218(95)90095-0"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0045-6535(98)00586-4"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrgentox.2005.08.014"},{"key":"e_1_2_1_14_1","unstructured":"FEMA.2003. Projeto Implementa\u00e7\u00e3o de Pr\u00e1ticas de Gerenciamento Integrado De Bacia Hidrogr\u00e1fica Para O Pantanal E Bacia Do Alto Paraguai \u2013 Agencia Nacional das \u00c1guas\/Fundo para o Meio Ambiente Mundial\/Programa das Na\u00e7\u00f5es Unidas para o Meio Ambiente\/Organiza\u00e7\u00e3o dos Estados Americanos. Resumo Executivo do Relat\u00f3rio Final. Available at:http:\/\/www.ana.gov.br\/gefap[accessed 20 July 2006]."},{"key":"e_1_2_1_15_1","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/S0378-4274(03)00032-8","article-title":"Ecotoxicological problems associated with contaminated sites","volume":"140","author":"Fent K","year":"2003","journal-title":"Toxicol Lett"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1161(88)90019-2"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/mutage\/11.4.315"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1161(90)90033-K"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-7992(90)90129-8"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1161(92)90032-H"},{"key":"e_1_2_1_21_1","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1002\/em.2860060206","article-title":"Somatic mutation and recombination test in Drosophila melanogaster","volume":"6","author":"Graf U","year":"1984","journal-title":"Environ Mutagen"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1218(89)90112-2"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0027-5107(92)90187-7"},{"key":"e_1_2_1_24_1","first-page":"169","volume-title":"Biomonitors and Biomarkers as Indicators of Environmental Change","author":"Guzm\u00e1n\u2010Rinc\u00f3n J","year":"1995"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0009-2797(85)90003-1"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1127\/archiv-hydrobiol\/137\/1996\/1"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrrev.2005.02.001"},{"key":"e_1_2_1_28_1","unstructured":"IoccaFA.2000.Caracteriza\u00e7\u00e3o Limnol\u00f3gica do C\u00f3rrego Sangradouro nas \u00e9pocas de seca e de chuva\u2014C\u00e1ceres\/MT. Disserta\u00e7\u00e3o de mestrado\u2014Departamento de Ecologia da Universidade de Bras\u00edlia.57p."},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/0027-5107(70)90038-2"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquatox.2004.09.001"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.2134\/jeq2002.1636"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1383-5718(03)00162-1"},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1415-47572006000100028"},{"key":"e_1_2_1_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/mutage\/geh058"},{"key":"e_1_2_1_35_1","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1002\/em.20281","article-title":"Assessing the impact of pollution on the Japaratuba river in Brazil using the Drosophila wing spot test","volume":"48","author":"Pantale\u00e3o SM","year":"2007","journal-title":"Environ Mol Mutagen"},{"key":"e_1_2_1_36_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1005201207088"},{"key":"e_1_2_1_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1383-5718(00)00142-X"},{"key":"e_1_2_1_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.etap.2005.05.002"},{"key":"e_1_2_1_39_1","first-page":"293","article-title":"Absence of genotoxicity of a phytotherapeutic extracts from Stryphnodendron adstringens (Mart.) coville in somatic and germ cells of Drosophila melanogaster","volume":"41","author":"Sousa NC","year":"2003","journal-title":"Genet Mol Biol"},{"key":"e_1_2_1_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/mutage\/16.5.385"},{"key":"e_1_2_1_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/0147-6513(91)90051-P"},{"key":"e_1_2_1_42_1","series-title":"Avalia\u00e7\u00e3o e controle da Drenagem Urbana","first-page":"548","author":"Vargas VMF","year":"2001"},{"key":"e_1_2_1_43_1","first-page":"427","volume-title":"The use of short and medium\u2010term tests for carcinogens and data on genetic effects in carcinogenic hazard evaluation","author":"Vogel EW","year":"1999"},{"key":"e_1_2_1_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0027-5107(99)00058-5"},{"key":"e_1_2_1_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrgentox.2004.02.009"},{"key":"e_1_2_1_46_1","volume-title":"Pantanal (NT0907). Wild World Report","author":"WWF","year":"2001"},{"key":"e_1_2_1_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1383-5718(03)00054-8"},{"key":"e_1_2_1_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2004.11.005"}],"container-title":["Environmental and Molecular Mutagenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fem.20404","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/em.20404","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T05:37:31Z","timestamp":1700026651000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/em.20404"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,6,5]]},"references-count":47,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2008,7]]}},"alternative-id":["10.1002\/em.20404"],"URL":"https:\/\/doi.org\/10.1002\/em.20404","archive":["Portico"],"relation":{},"ISSN":["0893-6692","1098-2280"],"issn-type":[{"value":"0893-6692","type":"print"},{"value":"1098-2280","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,6,5]]}}}