{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T17:47:59Z","timestamp":1773078479642,"version":"3.50.1"},"reference-count":124,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2009,3,26]],"date-time":"2009-03-26T00:00:00Z","timestamp":1238025600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Environ and Mol Mutagen"],"published-print":{"date-parts":[[2009,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Maintenance of genome stability is of fundamental importance for counteracting carcinogenesis. Many human genome instability syndromes exhibit a predisposition to cancer. An increasing body of epidemiological evidence has suggested a link between nutrient status and risk of cancer. Like other chemicals, nutrients can be toxic when consumed in excess. It has become clear that both nutritional deficiency and toxicity can compromise the integrity of the genome. This article focuses on roles of inorganic trace nutrients, including selenium, copper, zinc, and iron, in the redox regulation of genome stability and how they relate to the pathologies of genomic instability syndromes and cancer. Environ. Mol. Mutagen. 2009. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/em.20489","type":"journal-article","created":{"date-parts":[[2009,3,26]],"date-time":"2009-03-26T20:51:25Z","timestamp":1238100685000},"page":"349-360","source":"Crossref","is-referenced-by-count":22,"title":["Impact of inorganic nutrients on maintenance of genomic stability"],"prefix":"10.1002","volume":"50","author":[{"given":"Wen\u2010Hsing","family":"Cheng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,6,3]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/dji042"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/03630260500455557"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0027-5107(01)00070-7"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc886"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/21.11.2097"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/tx025639q"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/8.10.1461"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1493"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature03482"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05268"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.12.12.1143"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2007.03.018"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/biof.5520110122"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.05-5091fje"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.5.9.1830557"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/127.8.1445"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/128.7.1070"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2007.04.011"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0955-2863(95)80004-V"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.etp.2007.10.004"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1996.03540240035027"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1652"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-7258(98)00014-X"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.9.5125"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R600011200"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.2741\/1424"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2003.10.020"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3835(00)00531-0"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dnarep.2005.09.004"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.8351519"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dnarep.2006.10.009"},{"key":"e_1_2_1_33_1","first-page":"957","article-title":"Expression of selenium\u2010dependent glutathione peroxidase in human breast tumor cell lines","volume":"55","author":"Esworthy RS","year":"1995","journal-title":"Cancer Res"},{"key":"e_1_2_1_34_1","first-page":"899","article-title":"Selenium protection from DNA damage involves a Ref1\/p53\/Brca1 protein complex","volume":"26","author":"Fischer JL","year":"2006","journal-title":"Anticancer Res"},{"key":"e_1_2_1_35_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-06-0472"},{"key":"e_1_2_1_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3835(88)90308-4"},{"key":"e_1_2_1_37_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.30.11.2408"},{"key":"e_1_2_1_38_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj20011251"},{"key":"e_1_2_1_39_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M803150200"},{"key":"e_1_2_1_40_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1999.1563"},{"key":"e_1_2_1_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00284708"},{"key":"e_1_2_1_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature03485"},{"key":"e_1_2_1_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81683-9"},{"key":"e_1_2_1_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2008.8"},{"key":"e_1_2_1_45_1","doi-asserted-by":"publisher","DOI":"10.1159\/000106066"},{"key":"e_1_2_1_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1012"},{"key":"e_1_2_1_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2004.07.005"},{"key":"e_1_2_1_48_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.222679399"},{"key":"e_1_2_1_49_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/133.8.2543"},{"key":"e_1_2_1_50_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.26.16644"},{"key":"e_1_2_1_51_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-06-0063"},{"key":"e_1_2_1_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-6445(03)00050-0"},{"key":"e_1_2_1_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197808)42:2<626::AID-CNCR2820420232>3.0.CO;2-F"},{"key":"e_1_2_1_54_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/136.5.1311"},{"key":"e_1_2_1_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1388"},{"key":"e_1_2_1_56_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1373.1999.d01-143.x"},{"key":"e_1_2_1_57_1","doi-asserted-by":"publisher","DOI":"10.2174\/138161207782794202"},{"key":"e_1_2_1_58_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0712401105"},{"key":"e_1_2_1_59_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.23.13300"},{"key":"e_1_2_1_60_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1083516"},{"key":"e_1_2_1_61_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-0732"},{"key":"e_1_2_1_62_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkf478"},{"key":"e_1_2_1_63_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.22480"},{"key":"e_1_2_1_64_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-06-0643"},{"key":"e_1_2_1_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0027-5107(01)00076-8"},{"key":"e_1_2_1_66_1","first-page":"1957","article-title":"Effect of selenium and vitamin E on risk of prostate cancer and other cancers","volume":"276","author":"Lippman SM","year":"2008","journal-title":"JAMA"},{"key":"e_1_2_1_67_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10911-006-9003-7"},{"key":"e_1_2_1_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0027-5107(98)00220-6"},{"key":"e_1_2_1_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(95)00119-K"},{"key":"e_1_2_1_70_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOG.0b013e32801421bb"},{"key":"e_1_2_1_71_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-07-0324"},{"key":"e_1_2_1_72_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.7038"},{"key":"e_1_2_1_73_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200607061"},{"key":"e_1_2_1_74_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M309457200"},{"key":"e_1_2_1_75_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.14.6468"},{"key":"e_1_2_1_76_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/16.6.1335"},{"key":"e_1_2_1_77_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/15.10.4211"},{"key":"e_1_2_1_78_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg1746"},{"key":"e_1_2_1_79_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-213-44040"},{"key":"e_1_2_1_80_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2005.00507.x"},{"key":"e_1_2_1_81_1","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1182\/blood.V93.3.1116","article-title":"Mitomycin C\u2010induced DNA damage in Fanconi anemia: Cross\u2010linking or redox\u2010mediated effects?","volume":"93","author":"Pagano G","year":"1999","journal-title":"Blood"},{"key":"e_1_2_1_82_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M403527200"},{"key":"e_1_2_1_83_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.7.12b.2556"},{"key":"e_1_2_1_84_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1996.tb00997.x"},{"key":"e_1_2_1_85_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1293-338"},{"key":"e_1_2_1_86_1","first-page":"4041","article-title":"Prognostic significance of Ape1\/ref\u20101 subcellular localization in non\u2010small cell lung carcinomas","volume":"21","author":"Puglisi F","year":"2001","journal-title":"Anticancer Res"},{"key":"e_1_2_1_87_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/137.1.229S"},{"key":"e_1_2_1_88_1","doi-asserted-by":"publisher","DOI":"10.1038\/362059a0"},{"key":"e_1_2_1_89_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004390050437"},{"key":"e_1_2_1_90_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-04-0355"},{"key":"e_1_2_1_91_1","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1093\/oxfordjournals.aje.a113898","article-title":"Association between serum selenium and the risk of cancer","volume":"120","author":"Salonen JT","year":"1984","journal-title":"Am J Epidemiol"},{"key":"e_1_2_1_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-7992(93)90082-7"},{"key":"e_1_2_1_93_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.200600107"},{"key":"e_1_2_1_94_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1205129"},{"key":"e_1_2_1_95_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.212319799"},{"key":"e_1_2_1_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dnarep.2006.05.041"},{"key":"e_1_2_1_97_1","first-page":"682","article-title":"Possible protective effect of selenium against human cancer","volume":"100","author":"Shamberger RJ","year":"1969","journal-title":"Can Med Assoc J"},{"key":"e_1_2_1_98_1","first-page":"385","article-title":"Interactions of selenium compounds with other antioxidants in DNA damage and apoptosis in human normal keratinocytes","volume":"10","author":"Shen CL","year":"2001","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"e_1_2_1_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2006.05.004"},{"key":"e_1_2_1_100_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.11.24.3471"},{"key":"e_1_2_1_101_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1133427"},{"key":"e_1_2_1_102_1","first-page":"260","article-title":"Free radical generation by selenium compounds and their prooxidant toxicity","volume":"10","author":"Spallholz JE","year":"1997","journal-title":"Biomed Environ Sci"},{"key":"e_1_2_1_103_1","doi-asserted-by":"publisher","DOI":"10.1207\/S15327914NC401_8"},{"key":"e_1_2_1_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(98)00147-6"},{"key":"e_1_2_1_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dnarep.2008.07.015"},{"key":"e_1_2_1_106_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1293-344"},{"key":"e_1_2_1_107_1","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1093\/jn\/118.5.613","article-title":"Effect of dietary zinc or copper deficiency on the primary free radical defense system in rats","volume":"118","author":"Taylor CG","year":"1988","journal-title":"J Nutr"},{"key":"e_1_2_1_108_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.nutr.24.012003.132212"},{"key":"e_1_2_1_109_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgh144"},{"key":"e_1_2_1_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(02)00520-8"},{"key":"e_1_2_1_111_1","doi-asserted-by":"crossref","first-page":"1970","DOI":"10.1096\/fj.04-1895fje","article-title":"Werner syndrome cells escape hydrogen peroxide\u2010induced cell proliferation arrest","volume":"18","author":"von Kobbe KC","year":"2004","journal-title":"FASEB J"},{"key":"e_1_2_1_112_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0193-7"},{"key":"e_1_2_1_113_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.67.1.721"},{"key":"e_1_2_1_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2006.06.647"},{"key":"e_1_2_1_115_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2159"},{"key":"e_1_2_1_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4165(90)90018-R"},{"key":"e_1_2_1_117_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00061.2008"},{"key":"e_1_2_1_118_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-03-3834"},{"key":"e_1_2_1_119_1","first-page":"3713","article-title":"The apurinic\/apyrimidinic endonuclease (APE\/ref\u20101) DNA repair enzyme is elevated in premalignant and malignant cervical cancer","volume":"17","author":"Xu Y","year":"1997","journal-title":"Anticancer Res"},{"key":"e_1_2_1_120_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2280(1996)28:1<19::AID-EM5>3.0.CO;2-9"},{"key":"e_1_2_1_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(02)01360-6"},{"key":"e_1_2_1_122_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfn087"},{"key":"e_1_2_1_123_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2007.02.005"},{"key":"e_1_2_1_124_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-07-5186"},{"key":"e_1_2_1_125_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-06-0400"}],"container-title":["Environmental and Molecular Mutagenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fem.20489","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/em.20489","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T01:08:26Z","timestamp":1700010506000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/em.20489"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,6]]},"references-count":124,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2009,6]]}},"alternative-id":["10.1002\/em.20489"],"URL":"https:\/\/doi.org\/10.1002\/em.20489","archive":["Portico"],"relation":{},"ISSN":["0893-6692","1098-2280"],"issn-type":[{"value":"0893-6692","type":"print"},{"value":"1098-2280","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,6]]}}}