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Although ICL repair in mammalian cells is not fully understood, processing of these lesions is thought to begin by \u201cunhooking\u201d at the site of the damaged base accompanied by the generation of a double strand break and ultimately repair through translesion synthesis and homologous recombination. A key player in this repair process is the heterodimeric protein complex ERCC1\u2010XPF. Although some models of ICL repair restrict ERCC1\u2010XPF activity to the unhooking step, recent data suggest that this protein complex acts in additional downstream steps. Here, we review the evidence implicating ERCC1\u2010XPF in multiple steps of ICL repair. Environ. Mol. Mutagen., 2010. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/em.20583","type":"journal-article","created":{"date-parts":[[2010,4,29]],"date-time":"2010-04-29T19:36:53Z","timestamp":1272569813000},"page":"567-581","source":"Crossref","is-referenced-by-count":39,"title":["Multiple roles of ERCC1\u2010XPF in mammalian interstrand crosslink repair"],"prefix":"10.1002","volume":"51","author":[{"given":"Jennifer J.","family":"Rahn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald M.","family":"Adair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodney 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