{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T11:06:08Z","timestamp":1760267168583},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2011,12,15]],"date-time":"2011-12-15T00:00:00Z","timestamp":1323907200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Environ and Mol Mutagen"],"published-print":{"date-parts":[[2012,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The complement system plays an important role in inflammatory and immune responses, and recent evidence has suggested that it may also play a role in lymphomagenesis. We evaluated the association between genetic variation in complement system genes and risk of non\u2010Hodgkin lymphoma (NHL) in a population\u2010based case\u2013control study conducted among women in Connecticut. Tag SNPs in 30 complement genes were genotyped in 432 Caucasian incident cases and 494 frequency\u2010matched controls. A gene\u2010based analysis that adjusted for the number of tag SNPs genotyped in each gene showed a significant association with NHL overall (<jats:italic>P<\/jats:italic> = 0.04) as well as with diffuse large B\u2010cell lymphoma (DLBCL) (<jats:italic>P<\/jats:italic> = 0.01) for the <jats:italic>C1RL<\/jats:italic> gene. A SNP\u2010based analysis showed that a C&gt;T base substitution for <jats:italic>C1RL<\/jats:italic> rs3813729 (odds ratio (OR)<jats:sub>CT<\/jats:sub> = 0.60, 95% confidence interval (CI) = 0.42\u20130.87, <jats:italic>P<\/jats:italic><jats:sub>trend<\/jats:sub> = 0.0062) was associated with a decreased risk of overall NHL, as well as for DLBCL (OR<jats:sub>CT<\/jats:sub> = 0.39, 95% CI = 0.20\u20130.73; <jats:italic>P<\/jats:italic><jats:sub>trend<\/jats:sub> = 0.0034). Additionally, SNPs (<jats:italic>C2<\/jats:italic> rs497309, A&gt;C and <jats:italic>C3<\/jats:italic> rs344550, G&gt;C) in two complement genes were positively associated with marginal zone lymphoma (MZL) and <jats:italic>C1QG<\/jats:italic> was associated with CLL\/SLL, but these results were based on a limited number of cases. Our results suggest a potential role of the complement system in susceptibility to NHL; however, our results should be viewed as exploratory and further replication is needed to clarify these preliminary findings. Environ. Mol. Mutagen., 2012. Published 2011 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/em.21675","type":"journal-article","created":{"date-parts":[[2011,12,15]],"date-time":"2011-12-15T06:46:31Z","timestamp":1323931591000},"page":"145-151","source":"Crossref","is-referenced-by-count":15,"title":["Polymorphisms in complement system genes and risk of non\u2010Hodgkin lymphoma"],"prefix":"10.1002","volume":"53","author":[{"given":"Bryan A.","family":"Bassig","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tongzhang","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yawei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonja I.","family":"Berndt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theodore R.","family":"Holford","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"III","given":"H.Dean","family":"Hosgood","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"Leaderer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meredith","family":"Yeager","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Idan","family":"Menashe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Boyle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaiyong","family":"Zou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen","family":"Chanock","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathaniel","family":"Rothman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Lan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,12,15]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2567.2003.01569.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2009.07675.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/gepi.20162"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2009.11.014"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.626"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.510"},{"key":"e_1_2_6_8_1","first-page":"1884","article-title":"Autoimmune disease is a risk factor for the development of non\u2010Hodgkin's lymphoma","volume":"32","author":"Cuttner J","year":"2005","journal-title":"J Rheumatol"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.219"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-06-1056"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02905217"},{"key":"e_1_2_6_12_1","first-page":"921","article-title":"Maximum\u2010likelihood estimation of molecular haplotype frequencies in a diploid population","volume":"12","author":"Excoffier L","year":"1995","journal-title":"Mol Biol Evol"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2006.06141.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-004-1157-z"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.md.0000152371.22747.1e"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-10-4160"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20041196"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2007.070166"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2009.04.002"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-09-1918"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1655"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kem321"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1025626208861"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgl200"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2008.00759.x"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trstmh.2008.04.010"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(05)70434-4"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.MCR-10-0225"},{"key":"e_1_2_6_29_1","first-page":"S97","article-title":"Haptoglobin phenotypes in health and disorders","volume":"121","author":"Sadrzadeh SM","year":"2004","journal-title":"Am J Clin Pathol"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.419"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djj004"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.5402\/2011\/423571"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1080\/08916930701510673"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-4752"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0405692101"}],"container-title":["Environmental and Molecular Mutagenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fem.21675","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/em.21675","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T06:27:40Z","timestamp":1697005660000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/em.21675"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12,15]]},"references-count":34,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,3]]}},"alternative-id":["10.1002\/em.21675"],"URL":"https:\/\/doi.org\/10.1002\/em.21675","archive":["Portico"],"relation":{},"ISSN":["0893-6692","1098-2280"],"issn-type":[{"value":"0893-6692","type":"print"},{"value":"1098-2280","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,12,15]]}}}