{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T07:44:03Z","timestamp":1697096643093},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,2,20]],"date-time":"2012-02-20T00:00:00Z","timestamp":1329696000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Environ and Mol Mutagen"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A genomic region on chromosome 19q13.3 has been associated with cancer susceptibility. A Chinese case\u2013control study including 339 lung cancer cases and 358 controls was conducted using haplotype\u2010tagging SNP (htSNP) approach and HapMap database to evaluate the role of this locus. Four htSNPs (rs6966, rs2070830, rs4802252, and rs4803817) representing 95% of the common variations in <jats:italic>PPP1R13L<\/jats:italic>, as well as fourteen htSNPs encompassing <jats:italic>ERCC2, PPP1R13L<\/jats:italic>, and <jats:italic>ERCC1<\/jats:italic> on chromosome 19q13.3 were explored. Three haplotype blocks of strong linkage disequilibrium were identified. Overall, no single htSNP or haplotype associations were found for <jats:italic>PPP1R13L<\/jats:italic>. Highly significant differential distributions of haplotypes defined by both nine htSNPs covering <jats:italic>ERCC2<\/jats:italic> and <jats:italic>PPP1R13L<\/jats:italic> and fourteen htSNPs covering <jats:italic>ERCC2<\/jats:italic>, <jats:italic>PPP1R13L<\/jats:italic>, and <jats:italic>ERCC1<\/jats:italic> were found (global test <jats:italic>P<\/jats:italic> = 8.12<jats:italic>e<\/jats:italic>\u2212005 and <jats:italic>P<\/jats:italic> = 4.82<jats:italic>e<\/jats:italic>\u2212006, respectively). The results indicate that the biologically relevant genetic variation may be located at or near the subregion spanning from <jats:italic>ERCC2<\/jats:italic> inton19 rs1799787 to <jats:italic>PPP1R13L<\/jats:italic> intron8 rs2070830. Environ. Mol. Mutagen., 2012. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/em.21681","type":"journal-article","created":{"date-parts":[[2012,3,5]],"date-time":"2012-03-05T17:08:23Z","timestamp":1330967303000},"page":"239-245","source":"Crossref","is-referenced-by-count":5,"title":["Hapmap\u2010based evaluation of <i>ERCC2, PPP1R13L<\/i>, and <i>ERCC1<\/i> and lung cancer risk in a Chinese 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