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We evaluated NHL risk associated with genetic variation in pattern\u2010recognition genes using data from a case\u2013control study of NHL conducted in Connecticut women. Single nucleotide polymorphisms (SNPs) in 27 pattern\u2010recognition genes were genotyped in 432 Caucasian incident NHL cases and 494 frequency\u2010matched controls. Unconditional logistic regression was used to compute odds ratios (ORs) for NHL and common NHL subtypes in relation to individual SNPs and haplotypes. A gene\u2010based analysis that adjusted for the number of tagSNPs genotyped in each gene showed a significant association with overall NHL for the <jats:italic>MBP<\/jats:italic> gene (<jats:italic>P<\/jats:italic> = 0.028), with the diffuse large B\u2010cell lymphoma (DLBCL) subtype for the <jats:italic>MASP2<\/jats:italic> gene (<jats:italic>P<\/jats:italic> = 0.011), and with the follicular lymphoma (FL) subtype for <jats:italic>DEFB126<\/jats:italic> (<jats:italic>P<\/jats:italic> = 0.041). A SNP\u2010based analysis showed that <jats:italic>MBP<\/jats:italic> rs8094402 was associated with decreased risks of overall NHL (allele risk OR = 0.72, <jats:italic>P<\/jats:italic>\u2010trend = 0.0018), DLBCL (allele risk OR = 0.72, <jats:italic>P<\/jats:italic>\u2010trend = 0.036), and FL (allele risk OR = 0.67, <jats:italic>P<\/jats:italic>\u2010trend = 0.021), while <jats:italic>MASP2<\/jats:italic> rs12711521 was associated with a decreased risk of DLBCL (allele risk OR = 0.57, <jats:italic>P<\/jats:italic>\u2010trend = 0.0042). We also observed an increased risk of FL for <jats:italic>DEFB126<\/jats:italic> rs6054706 (allele risk OR = 1.39, <jats:italic>P<\/jats:italic>\u2010trend = 0.033). Our results suggest that genetic variation in pattern\u2010recognition genes is associated with the risk of NHL or specific NHL subtypes, but these preliminary findings require replication in larger studies. Mol. Mutagen. 2013. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/em.21739","type":"journal-article","created":{"date-parts":[[2012,10,11]],"date-time":"2012-10-11T13:28:32Z","timestamp":1349962112000},"page":"72-77","source":"Crossref","is-referenced-by-count":16,"title":["Polymorphisms in pattern\u2010recognition genes in the innate immunity system and risk of non\u2010Hodgkin lymphoma"],"prefix":"10.1002","volume":"54","author":[{"given":"Wei","family":"Hu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bryan A.","family":"Bassig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tongzhang","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yawei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonja I.","family":"Berndt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theodore R.","family":"Holford","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"III","given":"H. 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