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In this study, we genotyped these variants in a case\u2010control study of 602 NSOC cases and 605 controls and found that four of these variants (rs7590268, rs7632427, rs12543318, and rs1873147) were associated with susceptibility to NSOC. We further investigated the cumulative effects of these four variants and found a dose\u2010dependent increase in risk with the number of variant alleles. Furthermore, an association was observed between rs7590268 and a family history of NSOC. Our results provide confirmative evidence that these risk loci contribute to NSOC susceptibility in Chinese populations. Environ. Mol. Mutagen. 54:261\u2013267, 2013. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/em.21773","type":"journal-article","created":{"date-parts":[[2013,3,27]],"date-time":"2013-03-27T12:34:14Z","timestamp":1364387654000},"page":"261-267","source":"Crossref","is-referenced-by-count":26,"title":["Association and cumulative effects of GWAS\u2010identified genetic variants for nonsyndromic orofacial clefts in a Chinese population"],"prefix":"10.1002","volume":"54","author":[{"given":"Yongchu","family":"Pan","sequence":"first","affiliation":[{"name":"Institute of Stomatology Nanjing Medical University Nanjing China"},{"name":"State Key Laboratory of Reproductive Medicine Nanjing Medical University Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Han","sequence":"additional","affiliation":[{"name":"Institute of Stomatology Nanjing Medical University Nanjing 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