{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T10:50:55Z","timestamp":1774263055857,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,5,24]],"date-time":"2013-05-24T00:00:00Z","timestamp":1369353600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Environ and Mol Mutagen"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:p>Genotoxicity induced by neurocysticercosis has been demonstrated in vitro and in vivo in humans. The adult stage of <jats:italic>Taenia solium<\/jats:italic> lodges in the small intestine and is the main risk factor to acquire neurocysticercosis, nevertheless its carcinogenic potential has not been evaluated. In this study, we determined the genotoxic effect of <jats:italic>T. solium<\/jats:italic> infection in the hamster model of taeniosis. In addition, we assessed the effect of oral immunization with recombinant <jats:italic>T. solium<\/jats:italic> calreticulin (rTsCRT) plus cholera toxin as adjuvant on micronuclei induction, as this protein has been shown to induce 33\u201344% protection in the hamster model of taeniosis. Blood samples were collected from the orbital venous plexus of noninfected and infected hamsters at different days postinfection, as well as from orally immunized animals, to evaluate the frequency of micronucleated reticulocytes as a measure of genotoxicity induced by parasite exposure and rTsCRT vaccination. Our results indicate that infection with <jats:italic>T. solium<\/jats:italic> caused time\u2010dependent DNA damage in vivo and that rTsCRT immunization reduced the genotoxic damage induced by the presence of the tapeworms. Environ. Mol. Mutagen. 54:347\u2013353, 2013. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/em.21782","type":"journal-article","created":{"date-parts":[[2013,5,24]],"date-time":"2013-05-24T05:13:19Z","timestamp":1369372399000},"page":"347-353","source":"Crossref","is-referenced-by-count":16,"title":["Genotoxicity induced by <i>Taenia solium<\/i> and its reduction by immunization with calreticulin in a hamster model of taeniosis"],"prefix":"10.1002","volume":"54","author":[{"given":"Ana Mar\u00eda","family":"Salazar","sequence":"first","affiliation":[{"name":"Departamento de Medicina Gen\u00f3mica y Toxicolog\u00eda Ambiental Instituto de Investigaciones Biom\u00e9dicas, Universidad Nacional Aut\u00f3noma de M\u00e9xico (UNAM), M\u00e9xico, D.F. M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fela","family":"Mendlovic","sequence":"additional","affiliation":[{"name":"Departamento de Microbiolog\u00eda y Parasitolog\u00eda Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico (UNAM), M\u00e9xico, D.F. M\u00e9xico"},{"name":"Facultad de Ciencias de la Salud, Universidad An\u00e1huac, M\u00e9xico Norte Edo. de M\u00e9xico M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayra","family":"Cruz\u2010Rivera","sequence":"additional","affiliation":[{"name":"Departamento de Microbiolog\u00eda y Parasitolog\u00eda Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico (UNAM), M\u00e9xico, D.F. M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oscar","family":"Ch\u00e1vez\u2010Talavera","sequence":"additional","affiliation":[{"name":"Departamento de Medicina Gen\u00f3mica y Toxicolog\u00eda Ambiental Instituto de Investigaciones Biom\u00e9dicas, Universidad Nacional Aut\u00f3noma de M\u00e9xico (UNAM), M\u00e9xico, D.F. M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monserrat","family":"Sordo","sequence":"additional","affiliation":[{"name":"Departamento de Medicina Gen\u00f3mica y Toxicolog\u00eda Ambiental Instituto de Investigaciones Biom\u00e9dicas, Universidad Nacional Aut\u00f3noma de M\u00e9xico (UNAM), M\u00e9xico, D.F. M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillermina","family":"Avila","sequence":"additional","affiliation":[{"name":"Departamento de Microbiolog\u00eda y Parasitolog\u00eda Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico (UNAM), M\u00e9xico, D.F. M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Flisser","sequence":"additional","affiliation":[{"name":"Departamento de Microbiolog\u00eda y Parasitolog\u00eda Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico (UNAM), M\u00e9xico, D.F. M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Ostrosky\u2010Wegman","sequence":"additional","affiliation":[{"name":"Departamento de Medicina Gen\u00f3mica y Toxicolog\u00eda Ambiental Instituto de Investigaciones Biom\u00e9dicas, Universidad Nacional Aut\u00f3noma de M\u00e9xico (UNAM), M\u00e9xico, D.F. M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,5,24]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7519(02)00124-8"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-002-0605-8"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parint.2005.11.015"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/mutage\/geq075"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(09)70096-8"},{"key":"e_1_2_7_7_1","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1152\/ajplegacy.1960.198.6.1181","article-title":"Production and life span of erythrocytes during hibernation in the golden hamster","volume":"198","author":"Brock MA","year":"1960","journal-title":"Am J Physiol"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2004.09.023"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/jbiol168"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrgentox.2011.04.009"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1997.00550210057013"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.4.1740-1747.2003"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2003.11.018"},{"key":"e_1_2_7_14_1","first-page":"439","article-title":"Animal models for vaccine studies for visceral leishmaniasis","volume":"123","author":"Garg R","year":"2006","journal-title":"Indian J Med Res"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0027-5107(94)90251-8"},{"key":"e_1_2_7_16_1","first-page":"455","volume-title":"Harkness and Wagner's Biology and Medicine of Rabbits and Rodents","author":"Harkness JE","year":"2010"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1161(94)90039-6"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrfmmm.2011.05.013"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0027-5107(94)90242-9"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0188-0128(98)00027-X"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0035-9203(00)90441-3"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/tcm.10063"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00019.2007"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrgentox.2005.02.004"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.13.6379"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymeth.2009.07.007"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.35.21751"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.2174\/092986712799828337"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1645\/GE-3325RN"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/mutage\/18.2.211"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1383-5718(96)00070-8"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2011.11.001"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-7992(89)90042-0"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.niox.2004.08.004"},{"key":"e_1_2_7_35_1","first-page":"37","volume-title":"Manual de pr\u00e1cticas de patolog\u00eda cl\u00ednica veterinaria","author":"Quiroz GF JH","year":"2010"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrgentox.2004.01.007"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.2009.01163.x"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/mutage\/ger063"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/1098-2280(2000)36:3<163::AID-EM1>3.0.CO;2-P"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrgentox.2007.08.004"}],"container-title":["Environmental and Molecular Mutagenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fem.21782","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/em.21782","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T22:35:24Z","timestamp":1697668524000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/em.21782"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5,24]]},"references-count":39,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,6]]}},"alternative-id":["10.1002\/em.21782"],"URL":"https:\/\/doi.org\/10.1002\/em.21782","archive":["Portico"],"relation":{},"ISSN":["0893-6692","1098-2280"],"issn-type":[{"value":"0893-6692","type":"print"},{"value":"1098-2280","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5,24]]}}}