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We measured serum levels of IL\u20106, IL\u201010, and TNF\u2010\u03b1, which play a critical role in regulating various components of the immune system, in 71 exposed workers and 78 unexposed control workers. Repeated personal exposure measurements were taken in workers before blood collection using 3 M organic vapor monitoring badges. Compared to unexposed workers, the serum concentration of IL\u201010 in workers exposed to TCE was decreased by 70% (<jats:italic>P<\/jats:italic>\u2009=\u20090.001) after adjusting for potential confounders. Further, the magnitude of decline in IL\u201010 was &gt;60% and statistically significant in workers exposed to &lt;12 ppm as well as in workers with exposures \u2265 12 ppm of TCE, compared to unexposed workers. No significant differences in levels of IL\u20106 or TNF\u2010\u03b1 were observed among workers exposed to TCE compared to unexposed controls. Given that IL\u201010 plays an important role in immunologic processes, including mediating the Th1\/Th2 balance, our findings provide additional evidence that TCE is immunotoxic in humans. Environ. Mol. Mutagen. 54:450\u2013454, 2013. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/em.21789","type":"journal-article","created":{"date-parts":[[2013,6,25]],"date-time":"2013-06-25T05:50:41Z","timestamp":1372139441000},"page":"450-454","source":"Crossref","is-referenced-by-count":28,"title":["Occupational exposure to trichloroethylene and serum concentrations of IL\u20106, IL\u201010, and TNF\u2010alpha"],"prefix":"10.1002","volume":"54","author":[{"given":"Bryan A.","family":"Bassig","sequence":"first","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics, Occupational and Environmental Epidemiology Branch National Cancer Institute, NIH, DHHS Bethesda Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luoping","family":"Zhang","sequence":"additional","affiliation":[{"name":"Division of Environmental Health Sciences, School of Public Health University of California at Berkeley Berkeley California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaojiang","family":"Tang","sequence":"additional","affiliation":[{"name":"Guangdong Poison Control Center Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roel","family":"Vermeulen","sequence":"additional","affiliation":[{"name":"Institute for Risk Assessment Sciences, University of Utrecht Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Shen","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics, Occupational and Environmental Epidemiology Branch National Cancer Institute, NIH, DHHS Bethesda Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martyn T.","family":"Smith","sequence":"additional","affiliation":[{"name":"Division of Environmental Health Sciences, School of Public Health University of California at Berkeley Berkeley California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuangyi","family":"Qiu","sequence":"additional","affiliation":[{"name":"Guangdong Poison Control Center Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yichen","family":"Ge","sequence":"additional","affiliation":[{"name":"Guangdong Poison Control Center Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiying","family":"Ji","sequence":"additional","affiliation":[{"name":"Division of Environmental Health Sciences, School of Public Health University of California at Berkeley Berkeley California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boris","family":"Reiss","sequence":"additional","affiliation":[{"name":"Formerly of the University of Utrecht Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"III","given":"H. 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