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One possible underlying mechanism could be maternal obesity induced alterations in DNA methylation. However, this hypothesis is yet to be tested. We performed epigenomic mapping of cord blood among 308 Black mother\u2010infant pairs delivered at term at the Boston Medical Center using the Illumina HumanMethylation27 BeadChip. Linear regression and pathway analyses were conducted to evaluate the associations between DNA methylation levels and prepregnancy maternal BMI (&lt;25, 25\u201330, \u226530 kg\/m<jats:sup>2<\/jats:sup>). The methylation levels of 20 CpG sites were associated with maternal BMI at a significance level of <jats:italic>P<\/jats:italic>\u2010value &lt;10<jats:sup>\u22124<\/jats:sup> in the overall sample, and boys and girls, separately. One CpG site remained statistically significant after correction for multiple comparisons (FDR corrected <jats:italic>P<\/jats:italic>\u2010value = 0.04) and was annotated to a potential cancer gene, <jats:italic>ZCCHC10<\/jats:italic>. Some of the other CpG site annotated genes appear to be critical to the development of cancers and cardiovascular diseases (i.e., <jats:italic>WNT16, C18orf8, ANGPTL2, SAPCD2, ADCY3, PRR16, ERBB2, DOK2, PLAC1<\/jats:italic>). Significant findings from pathway analysis, such as infectious and inflammatory and lipid metabolism pathways, lends support for the potential impact of maternal BMI on the above stated disorders. This study demonstrates that prepregnancy maternal BMI might lead to alterations in offspring DNA methylation in genes relevant to the development of a range of complex chronic diseases, providing evidence of trans\u2010generational influence on disease susceptibility via epigenetic mechanism. Environ. Mol. Mutagen. 55:223\u2013230, 2014. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/em.21827","type":"journal-article","created":{"date-parts":[[2013,11,15]],"date-time":"2013-11-15T10:13:06Z","timestamp":1384510386000},"page":"223-230","source":"Crossref","is-referenced-by-count":120,"title":["Maternal preconception body mass index and offspring cord blood DNA methylation: Exploration of early life origins of disease"],"prefix":"10.1002","volume":"55","author":[{"given":"Xin","family":"Liu","sequence":"first","affiliation":[{"name":"Mary Ann and J. Milburn Smith Child Health Research Program, Ann &amp; Robert H. Lurie Children's Hospital of Chicago Research Center Department of Pediatrics Northwestern University Feinberg School of Medicine Chicago Illinois"},{"name":"Department of Preventive Medicine Northwestern University Feinberg School of Medicine Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Chen","sequence":"additional","affiliation":[{"name":"Mary Ann and J. Milburn Smith Child Health Research Program, Ann &amp; Robert H. Lurie Children's Hospital of Chicago Research Center Department of Pediatrics Northwestern University Feinberg School of Medicine Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui\u2010Ju","family":"Tsai","sequence":"additional","affiliation":[{"name":"Mary Ann and J. Milburn Smith Child Health Research Program, Ann &amp; Robert H. Lurie Children's Hospital of Chicago Research Center Department of Pediatrics Northwestern University Feinberg School of Medicine Chicago Illinois"},{"name":"Division of Biostatistics and Bioinformatics Institute of Population Health Sciences, National Research Institutes Zhunan Taiwan"},{"name":"Department of Medical Genetics College of Medicine, Kaohsiung Medical University Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoying","family":"Wang","sequence":"additional","affiliation":[{"name":"Center on the Early Life Origins of Disease Department of Population Family and Reproductive Health Bloomberg School of Public Health; Johns Hopkins University Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiumei","family":"Hong","sequence":"additional","affiliation":[{"name":"Center on the Early Life Origins of Disease Department of Population Family and Reproductive Health Bloomberg School of Public Health; Johns Hopkins University Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhou","sequence":"additional","affiliation":[{"name":"Biostatistics Research Core of Ann &amp; Robert H. Lurie Children's Hospital of Chicago Research Center Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunling","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Illinois at Chicago Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyu","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Illinois at Chicago Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Liu","sequence":"additional","affiliation":[{"name":"Mary Ann and J. Milburn Smith Child Health Research Program, Ann &amp; Robert H. Lurie Children's Hospital of Chicago Research Center Department of Pediatrics Northwestern University Feinberg School of Medicine Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongjian","family":"Wang","sequence":"additional","affiliation":[{"name":"Mary Ann and J. Milburn Smith Child Health Research Program, Ann &amp; Robert H. Lurie Children's Hospital of Chicago Research Center Department of Pediatrics Northwestern University Feinberg School of Medicine Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanchun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Mary Ann and J. Milburn Smith Child Health Research Program, Ann &amp; Robert H. 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