{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T17:47:55Z","timestamp":1763747275788},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,1,21]],"date-time":"2014-01-21T00:00:00Z","timestamp":1390262400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Environ and Mol Mutagen"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:p>Therapy\u2010related leukemia has been a recognized sequela of cancer treatment for decades with \u201csignature\u201d abnormalities of chromosomes 5, 7, and 11 observed in treated patients. Risk to oncology personnel handling anti\u2010cancer agents has also been documented by non\u2010specific measures of genotoxicity in blood and urine. Using chromosomal markers applied in clinical practice, we previously demonstrated in oncology workers, a dose\u2010related increase in abnormalities of chromosomes 5 and 7, known to be targets of alkylating agent exposure. In the analysis presented here, we extended that work to also assess damage resulting from non\u2010alkylating drug exposure. Peripheral blood lymphocytes from oncology personnel (<jats:italic>N<\/jats:italic>\u2009=\u200963) and non\u2010exposed controls (<jats:italic>N<\/jats:italic>\u2009=\u200946) was collected and examined using the fluorescent in situ hybridization technique with probes for targets on chromosomes 5, 7, and 11. Participants recorded drug handling events over a 6 week period. Important co\u2010variates were considered. Examining chromosomal outcomes as a function of drug handling frequency, we employed Poisson Regression to obtain incident rate ratios (IRRs) for selected drug handling frequencies. We found a dose\u2010related increase in the IRR for aberrations in all three chromosomes 5, 7, and 11, reaching statistical significance for chromosome 5, as a function of non\u2010alkylating drug handling. This suggests that the targeting of chromosome 5 is not limited to alkylating agent exposure, as some recent evidence in treated patients has also shown. Thus, the pattern of insult observed in treated patients appears to extend to oncology personnel exposed in the workplace. Environ. Mol. Mutagen. 55:369\u2013374, 2014. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/em.21852","type":"journal-article","created":{"date-parts":[[2014,1,22]],"date-time":"2014-01-22T04:55:07Z","timestamp":1390366507000},"page":"369-374","source":"Crossref","is-referenced-by-count":18,"title":["Chromosomal effects of non\u2010alkylating drug exposure in oncology personnel"],"prefix":"10.1002","volume":"55","author":[{"given":"Melissa A.","family":"McDiarmid","sequence":"first","affiliation":[{"name":"University of Maryland School of Medicine Baltimore Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bonnie","family":"Rogers","sequence":"additional","affiliation":[{"name":"Gillings School of Global Public Health University of North Carolina at Chapel Hill  North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc S.","family":"Oliver","sequence":"additional","affiliation":[{"name":"University of Maryland School of Medicine Baltimore Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,1,21]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"Cancer Chemotherapy & Biotherapy: Principles and Practice","author":"Chabner BA","year":"2001"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/JOM.0b013e3181f72b63"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.3322\/canjclin.56.6.354"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-110-9-740"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(79)91939-1"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2012.04.015"},{"key":"e_1_2_7_8_1","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1182\/blood.V60.2.404.404","article-title":"Correlation of occupation and karyotype in adults with acute non\u2010lymphocytic leukemia","volume":"60","author":"Golomb HM","year":"1982","journal-title":"Blood"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197602)37:2 <1014::AID-CNCR2820370805>3.0.CO;2-Z"},{"key":"e_1_2_7_10_1","unstructured":"International agency for research on cancer (IARC). 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