{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T11:36:38Z","timestamp":1791200198020,"version":"4.2.0"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,10,18]],"date-time":"2014-10-18T00:00:00Z","timestamp":1413590400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Nature Science Foundation of China","award":["81072263"],"award-info":[{"award-number":["81072263"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Environ and Mol Mutagen"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:p>Prenatal phthalate exposure has been shown to be associated with reduced fetal growth. Epigenetic changes such as DNA methylation might be a molecular mechanism through which phthalate exposure affects fetal growth. In this study, we examined associations between prenatal phthalate exposure, infant growth, and global DNA methylation in human placenta samples. We measured global DNA methylation of 119 subjects [55 fetal growth restriction (FGR) cases and 64 normal controls], as assessed by long interspersed nuclear element\u20101 (LINE\u20101) methylation, via quantitative polymerase chain reaction\u2010pyrosequencing. Prenatal phthalate exposure was assessed by measuring maternal urinary phthalate metabolites concentrations using high\u2010performance liquid chromatography\u2010tandem mass spectrometry. Concentrations of mono (2\u2010ethyl\u20105\u2010hydroxyhexyl) phthalate (MEHHP), mono (2\u2010ethyl\u20105\u2010oxohexyl) phthalate (MEOHP), and SumDEHP (molar sum of MEHP, MEHHP, and MEOHP) were significantly higher in FGR cases than those in normal controls (<jats:italic>P<\/jats:italic>\u2009=\u20090.002, 0.003, and 0.002, respectively). Placental LINE\u20101 methylation were found to be positively associated with fetal birth weight standard deviation scores, and negatively associated with urinary phthalate metabolites concentrations (MEHHP and SumDEHP). Every natural\u2010log unit increase in urinary concentrations of MEHHP and SumDEHP was associated with 0.015 (<jats:italic>\u03b2<\/jats:italic>\u2009=\u2009\u22120.015, <jats:italic>P<\/jats:italic>\u2009=\u20090.150) and 0.012 kg (<jats:italic>\u03b2<\/jats:italic>\u2009=\u2009\u22120.012, <jats:italic>P<\/jats:italic>\u2009=\u20090.167) decrease in birth weight mediated through LINE\u20101 methylation. These findings suggest that changes in placental LINE\u20101 methylation might be part of the underlying biological pathway between prenatal phthalate exposure and adverse fetal growth. Environ. Mol. Mutagen. 56:286\u2013292, 2015. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/em.21916","type":"journal-article","created":{"date-parts":[[2014,10,18]],"date-time":"2014-10-18T10:29:12Z","timestamp":1413628152000},"page":"286-292","source":"Crossref","is-referenced-by-count":102,"title":["Prenatal phthalate exposure, infant growth, and global <scp>DNA<\/scp> methylation of human placenta"],"prefix":"10.1002","volume":"56","author":[{"given":"Yan","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Environmental Health School of Public Health, Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui\u2010jing","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Maternal and Children's Health School of Public Health, Fudan University Shanghai 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