{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,27]],"date-time":"2024-07-27T17:48:41Z","timestamp":1722102521558},"reference-count":21,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Environ and Mol Mutagen"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:p>Gas station workers are exposed to chemicals known to be carcinogenic, especially benzene. The objective was to analyze the health problems of female gas station workers by means of sociodemographic and clinical questionnaires, and laboratorial exams.  We performed the genotyping of the polymorphisms <jats:italic>BRCA1<\/jats:italic>\/P871L and <jats:italic>BRCA1<\/jats:italic>\/Q356R by Polymerase Chain Reaction\u2010Restriction Fragment Length Polymorphism, and of variant allele <jats:italic>BRCA2<\/jats:italic>\/N372H through direct sequencing. The female workers showed a higher concentration of monocytes (<jats:italic>P<\/jats:italic>\u2009=\u20090.039); a greater number of spontaneous abortions (<jats:italic>P<\/jats:italic>\u2009=\u20090.025, OR\u2009=\u20094.977, 95% CI\u2009=\u20091.135\u201330.669); higher tobacco consumption (<jats:italic>P<\/jats:italic>\u2009=\u20090.013); and higher alcohol consumption (<jats:italic>P<\/jats:italic>\u2009=\u20090.05). The statistical analysis of the polymorphisms associated with the variables monocyte concentration and miscarriage number did not reveal a significant relationship, and smoking and spontaneous abortion were not statistically associated either. Environ. Mol. Mutagen. 58:730\u2013734, 2017. \u00a9 2017 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/em.22120","type":"journal-article","created":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T10:46:37Z","timestamp":1504262797000},"page":"730-734","source":"Crossref","is-referenced-by-count":3,"title":["Health survey and assessment of the polymorphisms <i>BRCA1<\/i>\/P871L, <i>BRCA1<\/i>\/Q356R, and <i>BRCA2<\/i>\/N372H in female gas station workers in Rio de Janeiro"],"prefix":"10.1002","volume":"58","author":[{"given":"Rafaele T.","family":"Silvestre","sequence":"first","affiliation":[{"name":"Circulating Biomarkers Laboratory Faculty of Medical Sciences, Rio de Janeiro State University Rio de Janeiro 20550\u2010170 Brazil"},{"name":"Graduate Program in Medical Sciences, Rio de Janeiro State University Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucas","family":"Delmonico","sequence":"additional","affiliation":[{"name":"Circulating Biomarkers Laboratory Faculty of Medical Sciences, Rio de Janeiro State University Rio de Janeiro 20550\u2010170 Brazil"},{"name":"Graduate Program in Medical Sciences, Rio de Janeiro State University Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryah","family":"Bravo","sequence":"additional","affiliation":[{"name":"Circulating Biomarkers Laboratory Faculty of Medical Sciences, Rio de Janeiro State University Rio de Janeiro 20550\u2010170 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F\u00e1bio","family":"Santiago","sequence":"additional","affiliation":[{"name":"Circulating Biomarkers Laboratory Faculty of Medical Sciences, Rio de Janeiro State University Rio de Janeiro 20550\u2010170 Brazil"},{"name":"Graduate Program in Medical Sciences, Rio de Janeiro State University Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luciano R.","family":"Scherrer","sequence":"additional","affiliation":[{"name":"Kennedy Faculty Belo Horizonte Minas Gerais Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aline dos Santos","family":"Moreira","sequence":"additional","affiliation":[{"name":"DNA Sequencing Platform, PDTIS\/FIOCRUZ Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marianne","family":"Tabalipa","sequence":"additional","affiliation":[{"name":"Technical Unit of Occupational Exposure Environmental and Cancer, Prevention and Surveillance Coordination, National Cancer Institute Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ubirani","family":"Otero","sequence":"additional","affiliation":[{"name":"Technical Unit of Occupational Exposure Environmental and Cancer, Prevention and Surveillance Coordination, National Cancer Institute Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Helena F.","family":"Ornellas","sequence":"additional","affiliation":[{"name":"Circulating Biomarkers Laboratory Faculty of Medical Sciences, Rio de Janeiro State University Rio de Janeiro 20550\u2010170 Brazil"},{"name":"Graduate Program in Medical Sciences, Rio de Janeiro State University Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gilda","family":"Alves","sequence":"additional","affiliation":[{"name":"Circulating Biomarkers Laboratory Faculty of Medical Sciences, Rio de Janeiro State University Rio de Janeiro 20550\u2010170 Brazil"},{"name":"Graduate Program in Medical Sciences, Rio de Janeiro State University Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyp211"},{"key":"e_1_2_6_3_1","unstructured":"Brazil Agency. 2017. 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