{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:42:43Z","timestamp":1786977763285,"version":"build-2736575974"},"reference-count":51,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,9,4]],"date-time":"2017-09-04T00:00:00Z","timestamp":1504483200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2017,9,4]],"date-time":"2017-09-04T00:00:00Z","timestamp":1504483200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000203","name":"U.S. Geological Survey","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000203","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000202","name":"U.S. Fish and Wildlife Service","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000202","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Environ and Mol Mutagen"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:p>\n                    Biological markers (biomarkers) sensitive to genotoxic and mutagenic contamination in fishes are widely used to identify exposure effects in aquatic environments. The micronucleus assay was incorporated into a suite of indicators to assess exposure to genotoxic and mutagenic contamination at five Great Lakes Areas of Concern (AOCs), as well as one non\u2010AOC (reference) site. The assay allowed enumeration of micronuclei as well as other nuclear abnormalities for both site and species comparisons. Erythrocyte abnormality data was also compared to skin and liver tumor prevalence and hepatic transcript abundance. Erythrocyte abnormalities were observed at all sites with variable occurrence and severity among sites and species. Benthic\u2010oriented brown bullhead (\n                    <jats:italic>Ameiurus nebulosus<\/jats:italic>\n                    ) and white sucker (\n                    <jats:italic>Catostomus commersonii<\/jats:italic>\n                    ) expressed lower rates of erythrocyte abnormalities, but higher rates of skin and liver neoplasms, when compared to pelagic\u2010oriented largemouth bass (\n                    <jats:italic>Micropterus salmoides<\/jats:italic>\n                    ) or smallmouth bass (\n                    <jats:italic>Micropterus dolomieu<\/jats:italic>\n                    ) at the same site. The reduced erythrocyte abnormalities, increased transcript abundance associated with Phase I and II toxicant responsive pathways, and increased neoplastic lesions among benthic\u2010oriented taxa may indicate the development of contaminant resistance of these species to more acute effects. Environ. Mol. Mutagen. 58:570\u2013581, 2017. \u00a9 2017 This article is a U.S. Government work and is in the public domain in the USA. Environmental and Molecular Mutagenesis published by Wiley Periodicals, Inc. on behalf of Environmental Mutagen Society\n                  <\/jats:p>","DOI":"10.1002\/em.22123","type":"journal-article","created":{"date-parts":[[2017,9,4]],"date-time":"2017-09-04T03:17:19Z","timestamp":1504495039000},"page":"570-581","source":"Crossref","is-referenced-by-count":62,"title":["Micronuclei and other erythrocyte nuclear abnormalities in fishes from the Great Lakes Basin, USA"],"prefix":"10.1002","volume":"58","author":[{"given":"Ryan P.","family":"Braham","sequence":"first","affiliation":[{"name":"School of Natural Resources West Virginia University Morgantown West Virgina 26506"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6647-9614","authenticated-orcid":false,"given":"Vicki S.","family":"Blazer","sequence":"additional","affiliation":[{"name":"U.S. Geological Survey, National Fish Health Research Laboratory Leetown Science Center Kearneysville West Virgina 25430"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cassidy H.","family":"Shaw","sequence":"additional","affiliation":[{"name":"U.S. Geological Survey, National Fish Health Research Laboratory Leetown Science Center Kearneysville West Virgina 25430"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia M.","family":"Mazik","sequence":"additional","affiliation":[{"name":"U.S. Geological Survey, West Virginia Cooperative Fish and Wildlife Research Unit West Virginia University Morgantown West Virgina 26506"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,9,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/tox.22156"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1218(95)90078-0"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-445X(97)00074-X"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1383-5718(00)00033-4"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquatox.2006.02.022"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10661-011-2266-5"},{"key":"e_1_2_7_8_1","doi-asserted-by":"crossref","unstructured":"BlazerVS MazikPM IwanowiczLR BrahamR HahnC WalshHL SperryAJ.2014a. 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