{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T23:17:48Z","timestamp":1780787868753,"version":"3.54.1"},"reference-count":44,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2017,8,19]],"date-time":"2017-08-19T00:00:00Z","timestamp":1503100800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005668","name":"Funda\u00e7\u00e3o de Apoio \u00e0 Pesquisa do Distrito Federal","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005668","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Environ and Mol Mutagen"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:p>Chromosomal alterations are commonly detected in patients with chronic lymphocytic leukemia (CLL) and impact disease pathogenesis, prognosis, and progression. Telomerase expression (<jats:italic>hTERT<\/jats:italic>), its activity and the telomere length are other important predictors of survival and multiple outcomes in CLL. SUV39H and SUV420H enzymes are histone methyltransferases (HMTases) involved in several cellular processes, including regulation of telomere length, heterochromatin organization, and genome stability. Here, we investigated whether <jats:italic>SUV39H1, SUV39H2, SUV420H1<\/jats:italic>, <jats:italic>SUV420H2<\/jats:italic>, and <jats:italic>h<\/jats:italic>TERT are associated with genomic instability of CLL. <jats:italic>SUV39H<\/jats:italic> (1\/2)<jats:italic>, SUV420H<\/jats:italic> (1\/2), and <jats:italic>h<\/jats:italic>TERT expression was determined in 59 CLL samples by real time PCR. In addition, ZAP\u201070 protein expression was evaluated by Flow Cytometry and patients\u2019 karyotype was defined by Cytogenetic Analysis. Low expression of <jats:italic>SUV39H1<\/jats:italic> was associated with the acquisition of altered and complex karyotypes. Conversely, high expression of <jats:italic>SUV39H2<\/jats:italic> correlated with cytogenetic abnormalities in CLL patients. The pattern of karyotypic alterations differed in samples with detectable or undetectable <jats:italic>h<\/jats:italic>TERT expression. Furthermore, <jats:italic>h<\/jats:italic>TERT expression in CLL showed a correlation with transcript levels of <jats:italic>SUV39H2<\/jats:italic>, which, in part, can explain the association between <jats:italic>SUV39H2<\/jats:italic> expression and cytogenetic abnormalities. Moreover, <jats:italic>SUV39H1<\/jats:italic> correlated with <jats:italic>SUV420H1<\/jats:italic> expression while <jats:italic>SUV420H2<\/jats:italic> was associated with all other investigated HMTases. Our data show that the differential expression of <jats:italic>SUV39H1 and SUV39H2<\/jats:italic> is associated with genomic instability and that the modulation of these HMTases can be an attractive approach to prevent CLL evolution. Environ. Mol. Mutagen. 58:654\u2013661, 2017. \u00a9 2017 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/em.22128","type":"journal-article","created":{"date-parts":[[2017,8,19]],"date-time":"2017-08-19T05:22:42Z","timestamp":1503120162000},"page":"654-661","source":"Crossref","is-referenced-by-count":12,"title":["Aberrant levels of <i>SUV39H1<\/i> and <i>SUV39H2<\/i> methyltransferase are associated with genomic instability in chronic lymphocytic leukemia"],"prefix":"10.1002","volume":"58","author":[{"given":"Juliana","family":"Carvalho Alves\u2010Silva","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de Patologia Molecular do C\u00e2ncer, Universidade de Bras\u00edlia, Av. 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Prof. Moraes Rego Recife PE 50670\u2010901 Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Madureira de Oliveira","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Patologia Molecular do C\u00e2ncer, Universidade de Bras\u00edlia, Av. L2 Norte Bras\u00edlia DF 70.910\u2010900 Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F\u00e1bio","family":"Morato de Oliveira","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Hematologia, Universidade de S\u00e3o Paulo, Av. Bandeirantes 3900 Ribeir\u00e3o Preto SP 14.048\u2010900 Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Magalhaes Rego","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Hematologia, Universidade de S\u00e3o Paulo, Av. 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