{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:48:00Z","timestamp":1790837280188,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,4,11]],"date-time":"2019-04-11T00:00:00Z","timestamp":1554940800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81573225"],"award-info":[{"award-number":["81573225"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81102178"],"award-info":[{"award-number":["81102178"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Environ and Mol Mutagen"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:p>Nonsyndromic cleft lip with or without cleft palate (NSCL\/P) is a common birth defect. Genetic variants causing syndromic orofacial clefts can also contribute to the etiology of NSCL\/P. The purpose of the present study was to explore gene\u2013gene (G\u2009\u00d7\u2009G) interaction using common single nucleotide polymorphic (SNP) markers in fibroblast growth factor (FGF) family and its receptors and T\u2010box genes, which were associated with syndromic orofacial clefts. Our study was conducted in 806 Chinese NSCL\/P case\u2010parent trios drawn from an international consortium. A total of 252 SNPs in <jats:italic>FGF8<\/jats:italic>, <jats:italic>FGF10<\/jats:italic>, <jats:italic>FGFR1<\/jats:italic>, <jats:italic>FGFR2<\/jats:italic>, and <jats:italic>TBX5<\/jats:italic> passed the quality control criteria and were included in the analysis. The interactions between SNPs in different genes were assessed using Cordell's method, which fitted a conditional logistic regression model. The analysis was performed using the R\u2010package trio (Version 3.8.0). Bonferroni correction was used to adjust for multiple comparisons, and the overall significance threshold was set as <jats:italic>P\u2009=<\/jats:italic> 1.98\u2009\u00d7\u200910<jats:sup>\u22124<\/jats:sup> (0.05\/252). Conditional logistic regression revealed the most significant interaction between rs2330542 in <jats:italic>FGF10<\/jats:italic> and rs1946295 in <jats:italic>TBX5<\/jats:italic>, which remained significant (<jats:italic>P<\/jats:italic>\u2009=\u20099.63\u2009\u00d7\u200910<jats:sup>\u22126<\/jats:sup>) after Bonferroni correction. The relative risk of allele C in rs2330542 (<jats:italic>FGF10<\/jats:italic>) was 1.02 (95%CI 0.81\u20131.28), while the relative risk was 1.42 (95%CI 1.03\u20131.97) when the exposure was a combination of allele C in rs2330542 and allele A in rs1946295 (<jats:italic>TBX5<\/jats:italic>). Our findings confirmed the importance of considering G\u2009\u00d7\u2009G interaction when exploring the genetic risk factors of NSCL\/P. Further investigations are warranted to validate the potential interaction and reveal the biological function of <jats:italic>FGF10\/FGFR2\/TBX5<\/jats:italic>. Environ. Mol. Mutagen. 2019. \u00a9 2019 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/em.22286","type":"journal-article","created":{"date-parts":[[2019,3,8]],"date-time":"2019-03-08T14:36:38Z","timestamp":1552055798000},"page":"602-606","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Exploring the interaction between FGF Genes and T\u2010box genes among chinese nonsyndromic cleft lip with or without cleft palate case\u2010parent trios"],"prefix":"10.1002","volume":"60","author":[{"given":"Wenyong","family":"Li","sequence":"first","affiliation":[{"name":"School of Public Health Peking University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengying","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Public Health Peking University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren","family":"Zhou","sequence":"additional","affiliation":[{"name":"School of Public Health Peking University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyue","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Public Health Peking University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongchen","family":"Zheng","sequence":"additional","affiliation":[{"name":"School of Public Health Peking University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongjing","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Public Health Peking University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhibo","family":"Zhou","sequence":"additional","affiliation":[{"name":"School of Stomatology Peking University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongping","family":"Zhu","sequence":"additional","affiliation":[{"name":"School of Stomatology Peking University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Public Health Peking University  Beijing China"},{"name":"Key Laboratory of Reproductive Health Ministry of Health  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terri H.","family":"Beaty","sequence":"additional","affiliation":[{"name":"School of Public Health Johns Hopkins University  Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,4,11]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.15537\/smj.2015.8.11891"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1002866"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.9503.1"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.580"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-013-1283-6"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwi132"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.10208"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/11.20.2463"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2933"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1122"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gdata.2016.08.017"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.adaj.2016.11.016"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00193.2017"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.2174\/1566524014666140414204829"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2009.01577.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1597\/10-208"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng985"},{"key":"e_1_2_6_19_1","first-page":"41","article-title":"The oral manifestations of Apert syndrome","volume":"12","author":"Kreiborg S","year":"1992","journal-title":"J Craniofac Genet Dev Biol"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0045441"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/gepi.21888"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-genom-090711-163729"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddu215"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60695-4"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.104471"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmedgenet-2013-102001"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI20384"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0607956104"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.31965"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.31673"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1757"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-0176"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdr2.1043"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/gepi.22023"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms14364"},{"key":"e_1_2_6_36_1","first-page":"442","article-title":"T\u2010box family of transcription factor\u2010TBX5, insights in development and disease","volume":"9","author":"Zhu T","year":"2017","journal-title":"Am J Transl Res"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa032909"}],"container-title":["Environmental and Molecular Mutagenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fem.22286","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/em.22286","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/em.22286","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/em.22286","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T06:55:24Z","timestamp":1694328924000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/em.22286"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,11]]},"references-count":36,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["10.1002\/em.22286"],"URL":"https:\/\/doi.org\/10.1002\/em.22286","archive":["Portico"],"relation":{},"ISSN":["0893-6692","1098-2280"],"issn-type":[{"value":"0893-6692","type":"print"},{"value":"1098-2280","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,11]]},"assertion":[{"value":"2018-07-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}