{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T07:28:27Z","timestamp":1789457307026,"version":"build-2803163510"},"reference-count":48,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,10,25]],"date-time":"2019-10-25T00:00:00Z","timestamp":1571961600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Environ and Mol Mutagen"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:p>Occupational radiation exposure may impact the reproductive outcome of male workers in the cardiac catheterization laboratory (cath Lab) who receive a dose of ~1\u201310 mSv\/year. An increased copy number variation (CNV) in azoospermia factor region c (AZFc) of the Y chromosome is a marker of spermatogenic failure, previously associated with radiation exposure. This study sought to investigate the association between paternal exposure in the Cath Lab and adverse reproductive outcomes as well as to assess the induction of CNV in the AZFc region. In a case\u2013control study, we enrolled 193 catheterization lab workers (Group I) and 164 age\u2010matched unexposed controls (Group II). Reproductive outcomes were assessed through a structured questionnaire. Two sequence\u2010tagged sites (SY1197 and SY579) in AZFc region were evaluated by qRT\u2010PCR in 83 exposed and 47 unexposed subjects. Exposed workers had a higher prevalence of low birth weight in offspring (Group I = 13% vs. II = 5.3%, <jats:italic>P<\/jats:italic> = 0.02; OR<jats:sub>adjusted<\/jats:sub> = 2.7; 95% CI: 1.1\u20136.3; <jats:italic>P<\/jats:italic> = 0.02). The mean of CNV (microdeletion and microduplication) for SY1197 was significantly higher in the exposed workers (Group I = 1.53\u2009\u00b1\u20090.85 vs. Group II = 1.02\u2009\u00b1\u20090.41; <jats:italic>P<\/jats:italic> = 0.0005). Despite the study design limitations, our findings show that chronic occupational radiation exposure of male workers is correlated with higher prevalence of low birth weight in offspring and instability in the Y chromosome AZFc region. Environ. Mol. Mutagen. 61:361\u2013368, 2020. \u00a9 2019 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/em.22341","type":"journal-article","created":{"date-parts":[[2019,10,12]],"date-time":"2019-10-12T13:24:41Z","timestamp":1570886681000},"page":"361-368","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Reproductive outcomes and Y chromosome instability in radiation\u2010exposed male workers in cardiac catheterization laboratory"],"prefix":"10.1002","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2163-0816","authenticated-orcid":false,"given":"Maria Grazia","family":"Andreassi","sequence":"first","affiliation":[{"name":"CNR Institute of Clinical Physiology  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Borghini","sequence":"additional","affiliation":[{"name":"CNR Institute of Clinical Physiology  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Vecoli","sequence":"additional","affiliation":[{"name":"CNR Institute of Clinical Physiology  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuela","family":"Piccaluga","sequence":"additional","affiliation":[{"name":"Niguarda Ca' Granda Hospital Milan  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulio","family":"Guagliumi","sequence":"additional","affiliation":[{"name":"Cardiovascular Department Papa Giovanni XXIII Hospital  Bergamo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Del Greco","sequence":"additional","affiliation":[{"name":"Department of Cardiology Santa Chiara Hospital  Trento Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiorenzo","family":"Gaita","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medical Science University of Turin  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugenio","family":"Picano","sequence":"additional","affiliation":[{"name":"CNR Institute of Clinical Physiology  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,10,25]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/em.20655"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/432048a"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.311.7003.485"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2014.12.233"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.115.003273"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.4238\/vol7-4gmr492"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1259\/0007-1285-53-628-271"},{"key":"e_1_2_8_9_1","volume-title":"FACTS\u2010Residency Applicants by Specialty and Sex, 2002\u20132008","author":"Association of American Medical Colleges","year":"2007"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/aja.2009.83"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2015.01.015"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1939-4640.1983.tb00765.x"},{"key":"e_1_2_8_13_1","first-page":"173","article-title":"Paternal exposures and cardiovascular malformations. 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