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Earth's ozone layer plays a vital role in blocking most of the extremely dangerous UVC; however, low frequency\/energy UVR (i.e., UVB and UVA) seeps through in minute amount and reaches the Earth's surface. Both UVB and UVA are physiologically responsible for a plethora of skin ailments, including skin cancers. The UVR is readily absorbed by the genomic DNA of skin cells, causing DNA bond distortion and UV\u2010induced DNA damage. As a defense mechanism, the DNA damage response (DDR) signaling in skin cells activates nucleotide excision repair (NER), which is responsible for the removal of UVR\u2010induced DNA photolesions and helps maintain the genomic integrity of the cells. Failure of proper NER function leads to mutagenesis and development of skin cancers. One of the deadliest form of skin cancers is melanoma which originates upon the genetic transformation of melanocytes, melanin producing skin cells. NER is a well\u2010studied DNA repair system in the whole skin, as a tissue, but not much is known about it in melanocytes. Therefore, this review encapsulates NER in melanocytes, with a specific focus on its functional regulators and their cross talks due to skin heterogeneity and divulging the potential knowledge gap in the field.<\/jats:p>","DOI":"10.1002\/em.22370","type":"journal-article","created":{"date-parts":[[2020,4,13]],"date-time":"2020-04-13T07:49:06Z","timestamp":1586764146000},"page":"736-751","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Solar ultraviolet\u2010induced <scp>DNA<\/scp> damage response: Melanocytes story in transformation to environmental melanomagenesis"],"prefix":"10.1002","volume":"61","author":[{"given":"Soumyadeep","family":"Sarkar","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences Washington State University  Spokane Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shobhan","family":"Gaddameedhi","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences Washington State University  Spokane Washington USA"},{"name":"Sleep and Performance Research Center Washington State University  Spokane Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,5,8]]},"reference":[{"key":"e_1_2_12_2_1","volume-title":"Cancer Facts and Figures 2020","author":"American Cancer Society (ACS)","year":"2020"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008390-199311000-00002"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.1992.tb00070.x"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.18553\/jmcp.2015.21.2.158"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.06.050"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0781.1995.tb00157.x"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.18.2.694"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2010.01201.x"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M406334200"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2010.083022"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/php.12377"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2016.10.488"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.2011.01043.x"},{"key":"e_1_2_12_15_1","volume-title":"Histology, Dermis","author":"Brown T.M.","year":"2020"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1301205"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5701063"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2010.355"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2010.09.019"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/218652a0"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.02-0752rev"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.12.045"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa050092"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.24539"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-09599-8_3"},{"issue":"7","key":"e_1_2_12_26_1","first-page":"851","article-title":"Environment and health: 3. 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