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Mice in groups of five were treated with cladribine or clofarabine. Blood samples were obtained from the mouse tails before treatment and every 8 hr posttreatment for 72\u2009hr. These samples were cytometrically scored for micronucleated reticulocytes (RETs), and the percentage of RETs was determined. The results showed that clofarabine and cladribine have early cytotoxic effects that are related to the genotoxic effects reported in previous studies; the drugs have both complex long\u2010lasting genotoxic and cytotoxic kinetic activity, with similar profiles that suggest a relationship between the genotoxic and cytotoxic parameters. The initial genotoxkinetics timing of clofarabine is equivalent to those of difluorodeoxycytidine, likely because both agents inhibit DNA polymerase. Clofarabine shows a higher genotoxic and cytotoxic efficiency than cladribine, in agreement with previous results.<\/jats:p>","DOI":"10.1002\/em.22394","type":"journal-article","created":{"date-parts":[[2020,6,22]],"date-time":"2020-06-22T09:44:06Z","timestamp":1592819046000},"page":"922-927","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["In vivo kinetics of the genotoxic and cytotoxic activities of cladribine and clofarabine"],"prefix":"10.1002","volume":"61","author":[{"given":"Jes\u00fas","family":"Quezada\u2010Vidal","sequence":"first","affiliation":[{"name":"Departamento de Biolog\u00eda Instituto Nacional de Investigaciones Nucleares, Centro Nuclear  Carretera M\u00e9xico\u2010Toluca s\/n La Marquesa, Ocoyoacac Estado de M\u00e9xico M\u00e9xico"},{"name":"Doctorado en Ciencias Biol\u00f3gicas y de la Salud Universidad Aut\u00f3noma Metropolitana\u2010Iztapalapa  Avenida San Rafael Atlixco 186 Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2501-2916","authenticated-orcid":false,"given":"Roc\u00edo","family":"Ort\u00edz\u2010Mu\u00f1iz","sequence":"additional","affiliation":[{"name":"Doctorado en Ciencias Biol\u00f3gicas y de la Salud Universidad Aut\u00f3noma Metropolitana\u2010Iztapalapa  Avenida San Rafael Atlixco 186 Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elsa","family":"Cervantes\u2010R\u00edos","sequence":"additional","affiliation":[{"name":"Doctorado en Ciencias Biol\u00f3gicas y de la Salud Universidad Aut\u00f3noma Metropolitana\u2010Iztapalapa  Avenida San Rafael Atlixco 186 Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virginia","family":"Cruz\u2010Vallejo","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda Instituto Nacional de Investigaciones Nucleares, Centro Nuclear  Carretera M\u00e9xico\u2010Toluca s\/n La Marquesa, Ocoyoacac Estado de M\u00e9xico M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro","family":"Morales\u2010Ram\u00edrez","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda Instituto Nacional de Investigaciones Nucleares, Centro Nuclear  Carretera M\u00e9xico\u2010Toluca s\/n La Marquesa, Ocoyoacac Estado de M\u00e9xico M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,7,2]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-017-0080-4"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrfmmm.2011.11.006"},{"key":"e_1_2_9_4_1","unstructured":"Commission on Life Sciences Institute of Laboratory Animal Research National Research Council. 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