{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:36:46Z","timestamp":1787168206332,"version":"build-2736575974"},"reference-count":24,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2023,6,26]],"date-time":"2023-06-26T00:00:00Z","timestamp":1687737600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30CA\u2010068485"],"award-info":[{"award-number":["P30CA\u2010068485"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01CA\u201055678"],"award-info":[{"award-number":["R01CA\u201055678"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["R01 ES\u2010029357"],"award-info":[{"award-number":["R01 ES\u2010029357"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["R01 ES\u2010031086"],"award-info":[{"award-number":["R01 ES\u2010031086"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Environ and Mol Mutagen"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Dietary exposure to aflatoxin B\n                    <jats:sub>1<\/jats:sub>\n                    (AFB\n                    <jats:sub>1<\/jats:sub>\n                    ) is a recognized risk factor for developing hepatocellular carcinoma. The mutational signature of AFB\n                    <jats:sub>1<\/jats:sub>\n                    is characterized by high\u2010frequency base substitutions, predominantly G&gt;T transversions, in a limited subset of trinucleotide sequences. The 8,9\u2010dihydro\u20108\u2010(2,6\u2010diamino\u20104\u2010oxo\u20103,4\u2010dihydropyrimid\u20105\u2010yl\u2010formamido)\u20109\u2010hydroxyaflatoxin B\n                    <jats:sub>1<\/jats:sub>\n                    (AFB\n                    <jats:sub>1<\/jats:sub>\n                    \u2010FapyGua) has been implicated as the primary DNA lesion responsible for AFB\n                    <jats:sub>1<\/jats:sub>\n                    \u2010induced mutations. This study evaluated the mutagenic potential of AFB\n                    <jats:sub>1<\/jats:sub>\n                    \u2010FapyGua in four sequence contexts, including hot\u2010 and cold\u2010spot sequences as apparent in the mutational signature. Vectors containing site\u2010specific AFB\n                    <jats:sub>1<\/jats:sub>\n                    \u2010FapyGua lesions were replicated in primate cells and the products of replication were isolated and sequenced. Consistent with the role of AFB\n                    <jats:sub>1<\/jats:sub>\n                    \u2010FapyGua in AFB\n                    <jats:sub>1<\/jats:sub>\n                    \u2010induced mutagenesis, AFB\n                    <jats:sub>1<\/jats:sub>\n                    \u2010FapyGua was highly mutagenic in all four sequence contexts, causing G&gt;T transversions and other base substitutions at frequencies of ~80%\u201390%. These data suggest that the unique mutational signature of AFB\n                    <jats:sub>1<\/jats:sub>\n                    is not explained by sequence\u2010dependent fidelity of replication past AFB\n                    <jats:sub>1<\/jats:sub>\n                    \u2010FapyGua lesions.\n                  <\/jats:p>","DOI":"10.1002\/em.22556","type":"journal-article","created":{"date-parts":[[2023,6,12]],"date-time":"2023-06-12T01:36:05Z","timestamp":1686533765000},"page":"9-13","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["The aflatoxin\n                    <scp>\n                      B\n                      <sub>1<\/sub>\n                    <\/scp>\n                    \u2010induced imidazole ring\u2010opened guanine adduct: High mutagenic potential that is minimally affected by sequence context"],"prefix":"10.1002","volume":"65","author":[{"given":"Irina G.","family":"Minko","sequence":"first","affiliation":[{"name":"Oregon Institute of Occupational Health Sciences, Oregon Health &amp; Science University  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Andrew H.","family":"Kellum","sequence":"additional","affiliation":[{"name":"Department of Chemistry Vanderbilt University  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael P.","family":"Stone","sequence":"additional","affiliation":[{"name":"Department of Chemistry Vanderbilt University  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Stephen","family":"Lloyd","sequence":"additional","affiliation":[{"name":"Oregon Institute of Occupational Health Sciences, Oregon Health &amp; Science University  Portland Oregon USA"},{"name":"Department of Molecular and Medical Genetics Oregon Health &amp; Science University  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,6,26]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-1943-3"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph17041215"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/350429a0"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja902052v"},{"issue":"15","key":"e_1_2_8_6_1","first-page":"E3101","article-title":"Mutational spectra of aflatoxin B1 in vivo establish biomarkers of exposure for human hepatocellular carcinoma","volume":"114","author":"Chawanthayatham S.","year":"2017","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrestox.8b00202"},{"issue":"1","key":"e_1_2_8_8_1","first-page":"197","article-title":"Temporal patterns of covalent DNA adducts in rat liver after single and multiple doses of aflatoxin B1","volume":"41","author":"Croy R.G.","year":"1981","journal-title":"Cancer Research"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1202214"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dnarep.2018.08.008"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/350427a0"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.220038.116"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfq283"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/foods11182828"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.03.001"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/tx5003832"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgu003"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1609024113"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dnarep.2019.03.004"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M117.802520"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1009802"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrestox.0c00517"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1620932114"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-15912-7"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.03.024"}],"container-title":["Environmental and Molecular Mutagenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/em.22556","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,16]],"date-time":"2024-04-16T02:21:00Z","timestamp":1713234060000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/em.22556"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,26]]},"references-count":24,"journal-issue":{"issue":"S1","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["10.1002\/em.22556"],"URL":"https:\/\/doi.org\/10.1002\/em.22556","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.22541\/au.167725982.25474227\/v1","asserted-by":"object"}]},"ISSN":["0893-6692","1098-2280"],"issn-type":[{"value":"0893-6692","type":"print"},{"value":"1098-2280","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,26]]},"assertion":[{"value":"2023-02-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}