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Thus, DNA repair mechanisms are a fundamental part of life. Nucleotide excision repair (NER) plays an important role in the removal of bulky DNA adducts, such as cyclobutane pyrimidine dimers from ultraviolet light or DNA crosslinking damage from platinum\u2010based chemotherapeutics, such as cisplatin. A main component for the NER pathway is transcription factor IIH (TFIIH), a multifunctional, 10\u2010subunit protein complex with crucial roles in both transcription and NER. In transcription, TFIIH is a component of the pre\u2010initiation complex and is important for promoter opening and the phosphorylation of RNA Polymerase II (RNA Pol II). During repair, TFIIH is important for DNA unwinding, recruitment of downstream repair factors, and verification of the bulky lesion. Several different disease states can arise from mutations within subunits of the TFIIH complex. Most strikingly are xeroderma pigmentosum (XP), XP combined with Cockayne syndrome (CS), and trichothiodystrophy (TTD). Here, we summarize the recruitment and functions of TFIIH in the two NER subpathways, global genomic (GG\u2010NER) and transcription\u2010coupled NER (TC\u2010NER). We will also discuss how TFIIH's roles in the two subpathways lead to different genetic disorders.<\/jats:p>","DOI":"10.1002\/em.22568","type":"journal-article","created":{"date-parts":[[2023,8,7]],"date-time":"2023-08-07T00:20:34Z","timestamp":1691367634000},"page":"72-81","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["The role of\n                    <scp>Transcription Factor IIH<\/scp>\n                    complex in nucleotide excision repair"],"prefix":"10.1002","volume":"65","author":[{"given":"Allyson","family":"Hoag","sequence":"first","affiliation":[{"name":"Department of Internal Medicine University of New Mexico  Albuquerque New Mexico USA"},{"name":"Comprehensive Cancer Center University of New Mexico  Albuquerque New Mexico United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingrui","family":"Duan","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of New Mexico  Albuquerque New Mexico USA"},{"name":"Comprehensive Cancer Center University of New Mexico  Albuquerque New Mexico United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of New Mexico  Albuquerque New Mexico USA"},{"name":"Comprehensive Cancer Center University of New Mexico  Albuquerque New Mexico United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,8,23]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.14.3.349"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/11.23.2919"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/em.22087"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms6849"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA117.000971"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2010.09.019"},{"issue":"2","key":"e_1_2_6_8_1","first-page":"41","article-title":"Diagnosis of Xeroderma pigmentosum and related DNA repair\u2010deficient cutaneous diseases","volume":"13","author":"Cleaver J.E.","year":"2008","journal-title":"Current Medical Literature. 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