{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T15:16:58Z","timestamp":1764688618254},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2008,4,22]],"date-time":"2008-04-22T00:00:00Z","timestamp":1208822400000},"content-version":"vor","delay-in-days":6686,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Environ and Mol Mutagen"],"published-print":{"date-parts":[[1990,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A wild\u2010type strain of herpes simplex virus type 1 (HSV\u20101:KOS) encoding a functional thymidine kinase (tk+) and a tk\u2010 mutant strain (HSV\u20101:PTK3B) were used to study the role of the viral tk in the repair of UV\u2010irradiated HSV\u20101 in human cells. UV survival of HSV\u20101:PTK3B was substantially reduced compared with that of HSV\u20101:KOS when infecting normal human cells. In contrast, the UV survival of HSV\u20101:PTK3B was similar to that of HSV\u20101:KOS when infecting excision repair\u2010deficient cells from a xeroderma pigmentosum patient from complementation group A. These results suggest that the repair of UV\u2010irradiated HSV\u20101 in human cells depends, in part at least, on expression of the viral tk and that the repair process influenced by tk activity is excision repair or a process dependent on excision repair.<\/jats:p>","DOI":"10.1002\/em.2850150104","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T16:49:58Z","timestamp":1172076598000},"page":"19-23","source":"Crossref","is-referenced-by-count":2,"title":["Evidence for an involvement of thymidine kinase in the excision repair of ultraviolet\u2010irradiated herpes simplex virus in human cells"],"prefix":"10.1002","volume":"15","author":[{"given":"Robert V. 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