{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T09:19:09Z","timestamp":1775035149986,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,7,14]],"date-time":"2006-07-14T00:00:00Z","timestamp":1152835200000},"content-version":"vor","delay-in-days":4942,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Environ and Mol Mutagen"],"published-print":{"date-parts":[[1993,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Fluorescence in situ hybridization and Giemsa staining of metaphase chromosomes were used to determine the relative frequencies of symmetric exchange aberrations (translocations) and asymmetric exchange aberrations (rings, dicentrics, and polycentrics) after exposure of human lymphoblastoid cells to restriction enzymes or X\u2010rays. The yield of symmetric exchanges was determined with the use of chromosome\u2010specific probes for human chromosomes 2 or 4, which were hybridized to metaphase chromosomes from cells exposed to the enzymes Pvull, Sacl, or Xbal or 3 or 5 Gy of X\u2010rays. The yield of asymmetric exchanges was determined in Giemsastained metaphase chromosomes from the same enzyme\u2010treated or irradiated cell population. About 1.5\u2010 to 3\u2010fold more symmetric than asymmetric exchanges were induced after restriction enzyme treatment. However, after X\u2010ray treatment the yield of dicentrics relative to the yield of reciprocal translocations was close to the expected 1:1 ratio.<\/jats:p>","DOI":"10.1002\/em.2850220106","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T18:44:23Z","timestamp":1172083463000},"page":"26-33","source":"Crossref","is-referenced-by-count":10,"title":["Analysis of restriction enzyme\u2010induced chromosomal aberrations by fluorescence in situ hybridization"],"prefix":"10.1002","volume":"22","author":[{"given":"Elma Abella","family":"Columna","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amato J.","family":"Giaccia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James W.","family":"Evans","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara L.","family":"Yates","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William F.","family":"Morgan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,14]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.2307\/3578132"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/09553008414551061"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/09553008814552291"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/09553007614550571"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1088\/0031-9155\/18\/1\/007"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/09553007814550431"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/09553008914551851"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.2307\/3577559"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/09553009014551051"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.990110113"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(87)90552-6"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90058-7"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-1119(85)90119-2"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/09553008914551351"},{"key":"e_1_2_1_16_1","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1080\/09553008914551161","volume":"56","journal-title":"Int J Radiat Biol"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-75682-5_8"},{"key":"e_1_2_1_18_1","series-title":"Fifth International Conference on Environmental Mutagens","first-page":"355","volume-title":"Mutation and the Environment, Part B: Metabolism, Testing Methods, and Chromosomes","author":"Morgan WF","year":"1990"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/09553009214550821"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/mutage\/7.1.3"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.9.2934"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90057-6"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4827(92)90202-J"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.10.6.3056"},{"key":"e_1_2_1_25_1","series-title":"Fifth International Conference on Environmental Mutagens","first-page":"385","volume-title":"Mutation and the Environment, Part B: Metabolism, Testing Methods, and Chromosomes","author":"Savage JRK","year":"1990"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/346868a0"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.2307\/3583658"},{"key":"e_1_2_1_28_1","first-page":"457","volume-title":"Advances in Radiation Research","author":"Wolff S","year":"1973"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.4.4.365"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(92)90904-V"}],"container-title":["Environmental and Molecular Mutagenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fem.2850220106","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/em.2850220106","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T18:28:38Z","timestamp":1698172118000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/em.2850220106"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,1]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1993,1]]}},"alternative-id":["10.1002\/em.2850220106"],"URL":"https:\/\/doi.org\/10.1002\/em.2850220106","archive":["Portico"],"relation":{},"ISSN":["0893-6692","1098-2280"],"issn-type":[{"value":"0893-6692","type":"print"},{"value":"1098-2280","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,1]]}}}