{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T17:29:48Z","timestamp":1764782988053},"reference-count":12,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,7,14]],"date-time":"2006-07-14T00:00:00Z","timestamp":1152835200000},"content-version":"vor","delay-in-days":4942,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Environ and Mol Mutagen"],"published-print":{"date-parts":[[1993,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>1\u2010\u03b2\u2010D\u2010arabinofuranosylcytosine (ara C) enhances the formation of chromosome rearrangements such as translocations or dicentric chromosomes in G<jats:sub>1<\/jats:sub> cells containing DNA lesions. The formation of rearrangements is hypothesized to be the result of inhibition of excision repair. Ara C has also been known to lead to the formation of chromosome rearrangements in G<jats:sub>1<\/jats:sub> cells in the absence of induced DNA lesions. It is not known whether a common mechanism is involved in these two processes. In the present study, we used excision repair\u2010deficient XP cells to investigate whether excision repair is involved in the formation of chromosome rearrangements in G<jats:sub>1<\/jats:sub> cells which do not contain induced DNA lesions.<\/jats:p><jats:p>G<jats:sub>0<\/jats:sub> Lymphocytes from an XP patient were either treated with 4\u2010nitroquinoline\u20101\u2010oxide (4NQO) or left untreated. Cells were then cultured in the presence of ara C for about 18 h. Aphidicolin (APC), which induces chromosome rearrangements in cells containing 4NQO\u2010induced DNA lesions, was used for comparison. The resulting frequency of dicentrics and rings (dic &amp; ring) was determined at the first mitoses after culture initiation. In 4NQO\u2010pretreated XP cells, the frequency of dic &amp; ring was not increased by post\u2010treatment with ara C or with APC. This result is thought to reflect the absence of excision repair in XP cells. However, normal induction of dic &amp; ring was observed in XP cells not pretreated with 4NQO but treated with ara C.<\/jats:p><jats:p>Thus, there seems to be two different processes involved in the induction of G<jats:sub>1<\/jats:sub> rearrangements: excision repair\u2010dependent and excision repair\u2010independent. UV\u2010endonuclease is not involved in excision repair\u2010independent rearrangements.<\/jats:p>","DOI":"10.1002\/em.2850220415","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T19:03:34Z","timestamp":1172084614000},"page":"271-274","source":"Crossref","is-referenced-by-count":3,"title":["Evidence for excision repair\u2010dependent and independent processes in ara C\u2010induced chromosome rearrangements in G<sub>1<\/sub> human lymphocytes"],"prefix":"10.1002","volume":"22","author":[{"given":"Kunikazu","family":"Kishi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Sekizawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,14]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"37","volume-title":"DNA Repair, Chromosome Alterations and Chromatin Structure","author":"Bender MA","year":"1982"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4827(67)90066-3"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1041080207"},{"key":"e_1_2_1_5_1","volume-title":"An International System for Human Cytogenetic Nomenclature","author":"ISCN","year":"1985"},{"key":"e_1_2_1_6_1","first-page":"819","article-title":"Rate and extent of DNA repair in nondividing human diploid fibroblasts","volume":"41","author":"Kantor GJ","year":"1981","journal-title":"Cancer Res"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0027-5107(87)90257-0"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0047-6374(86)90038-2"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0027-5107(85)90183-6"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000131721"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0027-5107(81)90021-X"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0027-5107(73)90202-9"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0027-5107(80)90027-5"}],"container-title":["Environmental and Molecular Mutagenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fem.2850220415","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/em.2850220415","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T23:27:38Z","timestamp":1698190058000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/em.2850220415"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,1]]},"references-count":12,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1993,1]]}},"alternative-id":["10.1002\/em.2850220415"],"URL":"https:\/\/doi.org\/10.1002\/em.2850220415","archive":["Portico"],"relation":{},"ISSN":["0893-6692","1098-2280"],"issn-type":[{"value":"0893-6692","type":"print"},{"value":"1098-2280","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,1]]}}}