{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T15:16:48Z","timestamp":1764688608022},"reference-count":12,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,7,14]],"date-time":"2006-07-14T00:00:00Z","timestamp":1152835200000},"content-version":"vor","delay-in-days":4212,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Environ and Mol Mutagen"],"published-print":{"date-parts":[[1995,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Two carcinogens, ethylene dibromide and benzene, were used to induce delayed (germinal mosaic) sex\u2010linked recessive lethal mutations in spermatozoa and spermatids of adult Drosophila males. Significant numbers of delayed mutations (in F<jats:sub>3<\/jats:sub>) were scored in absence of conventional (in F<jats:sub>2<\/jats:sub>) mutations. A large proportion of nonlethal F<jats:sub>2<\/jats:sub> cultures carried delayed mutations, so much so that, in some cultures, all F<jats:sub>2<\/jats:sub> females were carriers of mutations. The mechanism through which single strand damage to treated X chromosomes can result in such delayed lethals is discussed. These observations indicate that the delayed mutation test should be used for testing the mutagenicity of environmental compounds, especially carcinogens, which tested negative in the conventional sex\u2010linked recessive lethal mutation test. The data will support the relationship between mutagenesis and carcinogenesis and, also will further enhance the sensitivity of the Drosophila mutation assay. \u00a9 1995 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/em.2850250307","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T19:08:17Z","timestamp":1172084897000},"page":"211-215","source":"Crossref","is-referenced-by-count":2,"title":["Induction of delayed mutations by benzene and ethylene dibromide in drosophila"],"prefix":"10.1002","volume":"25","author":[{"given":"Purushottam","family":"Kale","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ranjini","family":"Kale","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,14]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0080455X00009814"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4899-3103-0_1"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/em.2850230103"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1093\/genetics\/54.1.31","article-title":"Ethyl methanesulfonate induced lethals in Drosophila: Frequency dose relations and multiple mosaicism","volume":"54","author":"Epler JL","year":"1966","journal-title":"Genetics"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/em.2850230310"},{"key":"e_1_2_1_7_1","volume-title":"Genetics","author":"Jenkins JB","year":"1975"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1218(79)90078-8"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/em.2860050210"},{"key":"e_1_2_1_10_1","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1093\/genetics\/55.3.619","article-title":"The relation of germ line mosaicism to somatic mosaicism in Drosophila","volume":"55","author":"Lee WR","year":"1967","journal-title":"Genetics"},{"key":"e_1_2_1_11_1","first-page":"527","article-title":"The production of mosaics by incorporation of P32 into DNA of Drosophila melanogaster spermatozoa","volume":"56","author":"Lee WR","year":"1967","journal-title":"Genetics"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0027-5107(70)90133-8"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0027-5107(79)90144-1"}],"container-title":["Environmental and Molecular Mutagenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fem.2850250307","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/em.2850250307","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T01:34:08Z","timestamp":1698370448000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/em.2850250307"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,1]]},"references-count":12,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1995,1]]}},"alternative-id":["10.1002\/em.2850250307"],"URL":"https:\/\/doi.org\/10.1002\/em.2850250307","archive":["Portico"],"relation":{},"ISSN":["0893-6692","1098-2280"],"issn-type":[{"value":"0893-6692","type":"print"},{"value":"1098-2280","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,1]]}}}