{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T21:30:52Z","timestamp":1767648652877},"reference-count":49,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,7,14]],"date-time":"2006-07-14T00:00:00Z","timestamp":1152835200000},"content-version":"vor","delay-in-days":8960,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Environ. mutagen"],"published-print":{"date-parts":[[1982,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The influence of caffeine on cytotoxicity and postreplication repair of DNA was examined following exposure of several cell types to physical and chemical agents known to damage DNA. The cell types used in this study were normal human fibroblasts (HS\u2010WP), human xeroderma pigmentosum fibroblasts (SGL), Chinese hamster V79 cells, mouse BALB\/c\u20103T3 cells, and secondary Syrian hamster embryo cells. The DNA damaging agents were ultraviolet light (UV), N\u20102\u2010acetoxyfluorenylacetamide (AFAA), nitroquinoline\u2010N\u2010oxide (NQO) and N\u2010methyl\u2010N\u2032\u2010nitro\u2010N\u2010nitrosoguanidine (MNNG). Induction of cytotoxicity in Chinese hamster V79 cells due to ultraviolet light or AFAA exposure was enhanced by caffeine at a concentration of 1.0 mM in the culture medium, but not at 0.2 or 0.05 mM. Caffeine also inhibited postreplication repair in these cells at the same concentrations. In contrast, postreplication repair was not affected by caffeine at concentrations up to 1.0 mM in normal human fibroblasts (HS\u2010WP), human xeroderma pigmentosum fibroblasts (SGL), secondary Syrian hamster embryo cells, and mouse BALB\/c\u20103T3 cells following treatment with ultraviolet light, AFAA, NQO, or MNNG. Cytotoxicity in BALB\/c\u20103T3 cells following exposure to ultraviolet light or AFAA was enhanced in the presence of caffeine at 1.0 or 0.2 mM, although these concentrations of caffeine had no effect on postreplication repair in these cells. The inhibitory effect of caffeine on postreplication repair was found only in Chinese hamster V79 cells among the five cell types used in this study. Both normal and xeroderma pigmentosum human cells repaired mutagen\u2010induced DNA damage equally well in the absence or presence of caffeine at concentrations of 1.0 mM or less.<\/jats:p>","DOI":"10.1002\/em.2860040206","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T21:50:09Z","timestamp":1172008209000},"page":"143-162","source":"Crossref","is-referenced-by-count":9,"title":["Variations among species and cell types in the effects of caffeine on mutagen\u2010induced cytotoxicity and postreplication repair of DNA"],"prefix":"10.1002","volume":"4","author":[{"given":"Andrew","family":"Sivak","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larisa","family":"Rudenko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda Gaudio","family":"Teague","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,14]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1040720208"},{"key":"e_1_2_1_3_1","first-page":"461","article-title":"DNA repair in xeroderma pigmentosum cells treated with combinations of ultraviolet radiation and N\u2010acetoxy\u20102\u2010acetyl\u2010animofluorene","volume":"39","author":"Ahmed FE","year":"1979","journal-title":"Cancer Res"},{"key":"e_1_2_1_4_1","first-page":"1488","article-title":"Ectrodactylie provoquee par la cafeine chez les rongeurs. Role des facteurs specifiques et genetiques","volume":"164","author":"Bertrand M","year":"1970","journal-title":"C R Soc Biol"},{"key":"e_1_2_1_5_1","unstructured":"BowdenGT HsuIC HarrisCC(in press): The effect of caffeine on cytotoxicity mutagenesis and sister\u2010chromatid exchanges in Chinese hamster cells treated with dihydrodiol epoxide derivatives of benzo [a]pyrene.Mutat Res(in press)."},{"key":"e_1_2_1_6_1","first-page":"2709","article-title":"Post\u2010replication repair of DNA in ultraviolet light\u2010irradiated normal and malignantly transformed mouse epidermal cell cultures","volume":"38","author":"Bowden GT","year":"1978","journal-title":"Cancer Res"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(74)85932-1"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.3109\/03602537508993756"},{"issue":"3","key":"e_1_2_1_9_1","first-page":"584","article-title":"Human metabolism of caffeine","volume":"38","author":"Callahan MM","year":"1979","journal-title":"Fed. Proc."},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0027-5107(77)90050-1"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0027-5107(78)90144-6"},{"key":"e_1_2_1_12_1","first-page":"1147","article-title":"Defective and enhanced post\u2010replication repair in classical and variant xeroderma pigmentosum cells treated with N\u2010acetoxy\u20102\u2010acetylaminofluorene","volume":"38","author":"D'Ambrosio SM","year":"1978","journal-title":"Cancer Res"},{"key":"e_1_2_1_13_1","first-page":"2720","article-title":"Caffeine enhancement of chemical carcinogen\u2010induced transformation of cultured Syrian hamster cells","volume":"34","author":"Donovan PJ","year":"1974","journal-title":"Cancer Res"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0027-5107(78)90115-X"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0027-5107(78)90030-1"},{"key":"e_1_2_1_16_1","first-page":"2780","article-title":"Post\u2010replication repair of alkylation damage to DNA of mammalian cells in culture","volume":"35","author":"Fujiwara Y","year":"1975","journal-title":"Cancer Res"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0027-5107(76)90058-0"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1745-4565.1978.tb00276.x"},{"key":"e_1_2_1_19_1","first-page":"475","volume-title":"Carcinogenesis: Vol 2. Mechanisms of Tumor Promotion and Cocarcinogenesis","author":"Hicks RM","year":"1978"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-4274(79)90078-X"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0027-5107(78)90130-6"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/258248a0"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4827(73)90356-X"},{"key":"e_1_2_1_24_1","volume-title":"Caffeine and Chromosomes","author":"Kihlman KR","year":"1977"},{"issue":"2","key":"e_1_2_1_25_1","first-page":"135","article-title":"Review of the genetic effects of caffeine","volume":"13","author":"Legator MS","year":"1977","journal-title":"J Environ Sci Health"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1972.tb02550.x"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2836(72)90418-4"},{"key":"e_1_2_1_28_1","first-page":"904","article-title":"Repair of ultraviolet light damage in a variety of human fibroblast cell strains","volume":"37","author":"Lehmann AR","year":"1977","journal-title":"Cancer Res"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/258760a0"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/0027-5107(79)90213-6"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/0009-2797(78)90064-9"},{"key":"e_1_2_1_32_1","first-page":"395","article-title":"Effect of phenacetin and caffeine on the urinary bladder of rats treated with N\u2010Butyl\u2010N\u2010(4\u2010Hydroxybutyl)\u2010nitrosamine","volume":"69","author":"Nakanishi K","year":"1978","journal-title":"Gann"},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/260547a0"},{"key":"e_1_2_1_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/0027-5107(77)90054-9"},{"key":"e_1_2_1_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(78)90279-X"},{"key":"e_1_2_1_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/6.3.1151"},{"key":"e_1_2_1_37_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.76.8.3927"},{"key":"e_1_2_1_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910190508"},{"key":"e_1_2_1_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/0027-5107(79)90021-6"},{"key":"e_1_2_1_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/252069a0"},{"key":"e_1_2_1_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2836(68)90445-2"},{"key":"e_1_2_1_42_1","first-page":"727","article-title":"Effect of caffeine on ultraviolet mutagenesis in V79 Chinese hamster cells","volume":"69","author":"Tatsumi M","year":"1978","journal-title":"Gann"},{"key":"e_1_2_1_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-008X(73)80003-1"},{"key":"e_1_2_1_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-008X(73)80002-X"},{"key":"e_1_2_1_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1110(77)90016-1"},{"key":"e_1_2_1_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00527403"},{"key":"e_1_2_1_47_1","doi-asserted-by":"publisher","DOI":"10.2307\/3574576"},{"key":"e_1_2_1_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/0027-5107(78)90147-1"},{"key":"e_1_2_1_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-6264(77)80199-5"},{"key":"e_1_2_1_50_1","first-page":"1073","article-title":"Effect inhibiteur de la cafeine sur l'induction de cancere cutanes par les rayons ultraviolets chez la souris","volume":"277","author":"Zajdela F","year":"1973","journal-title":"C R Hebd Seances Acad Sci Ser D"}],"container-title":["Environmental Mutagenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fem.2860040206","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/em.2860040206","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T02:13:45Z","timestamp":1699323225000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/em.2860040206"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1982,1]]},"references-count":49,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1982,1]]}},"alternative-id":["10.1002\/em.2860040206"],"URL":"https:\/\/doi.org\/10.1002\/em.2860040206","archive":["Portico"],"relation":{},"ISSN":["0192-2521","1930-238X"],"issn-type":[{"value":"0192-2521","type":"print"},{"value":"1930-238X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1982,1]]}}}