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We report here the ability of some metal compounds to cause the induction of \u03bb prophage in <jats:italic>E coli<\/jats:italic> WP2<jats:sub>S<\/jats:sub>(\u03bb). By far the strongest inducing ability was observed with K2CrO4, followed by Pb(N0<jats:sub>3<\/jats:sub>)<jats:sub>2<\/jats:sub> &gt; MnCl<jats:sub>2<\/jats:sub> &gt; Ni(OOCCH<jats:sub>3<\/jats:sub>)<jats:sub>2<\/jats:sub> &gt; CrCl<jats:sub>2<\/jats:sub> &gt; NaWO<jats:sub>4<\/jats:sub> &gt; Na<jats:sub>2<\/jats:sub>MoO<jats:sub>4<\/jats:sub> &gt; KMnO<jats:sub>4<\/jats:sub>. With the exception of chromate, long\u2010term exposures in a narrow, subtoxic dose range were required in order to demonstrate phage induction. A new microtiter assay for \u03bb prophage induction, which incorporates these features, is described. This system also was able to detect very small amounts of organic carcinogens.<\/jats:p>","DOI":"10.1002\/em.2860060108","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T22:17:08Z","timestamp":1172009828000},"page":"59-69","source":"Crossref","is-referenced-by-count":88,"title":["The genetic toxicology of metal compounds: I. Induction of \u03bb prophage in <i>E coli<\/i> WP2<sub>S<\/sub>(\u03bb)"],"prefix":"10.1002","volume":"6","author":[{"given":"T. G.","family":"Rossman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Molina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. 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