{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T12:11:21Z","timestamp":1697976681020},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,7,14]],"date-time":"2006-07-14T00:00:00Z","timestamp":1152835200000},"content-version":"vor","delay-in-days":7499,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Environ. mutagen"],"published-print":{"date-parts":[[1986,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Little is known about the relative frequency of induction of nondisjunction in the first and second divisions of meiosis. The Killer of prune system is a semiselective <jats:italic>Drosophila<\/jats:italic> aneuploidy assay designed to detect chromosome gain resulting from first\u2010 or second\u2010division nondisjunction in males. The system can also detect X\u2010Y interchange. Extensive data from nonmutagenized controls indicate that all the expected phenotypes can be recovered. Spontaneous nondisjunction in the first division is three times more frequent than in the second division. Spontaneous interchange between the X chromosome and Y<jats:sup>S<\/jats:sup> is six times more frequent than between the X chromosome and Y<jats:sup>L<\/jats:sup>. Exposures of larval males to X\u2010rays, 35\u00b0C heat shock, and colchicine were performed. X\u2010ray exposure induced an increase in X\u2010Y interchange events only. A 24\u2010hr heat shock induced an increase in first\u2010division nondisjunction and one type of interchange event. Colchicine failed to induce both nondisjunction and interchange, although it did decrease fertility. The Killer of prune test is of potential value because it allows for the assessment of the relative sensitivities of the two meiotic divisions to perturbations in chromosome number.<\/jats:p>","DOI":"10.1002\/em.2860080202","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T22:53:58Z","timestamp":1172012038000},"page":"173-182","source":"Crossref","is-referenced-by-count":2,"title":["A semiselective test for the detection of first\u2010 and second\u2010division nondisjunction in <i>Drosophila melanogaster<\/i>"],"prefix":"10.1002","volume":"8","author":[{"given":"Polly A.","family":"Foureman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,14]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.34.2.525"},{"key":"e_1_2_1_3_1","first-page":"115","article-title":"Crossing over between Y chromosomes in male Drosophila","volume":"32","author":"Brosseau GE","year":"1958","journal-title":"Dros Inf Serv"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.52.5.1248"},{"key":"e_1_2_1_5_1","first-page":"276","article-title":"An assay for the detection of induced aneuploidy and chromosome breakage in Drosophila","volume":"2","author":"Foureman PA","year":"1980","journal-title":"Environ Mutagen"},{"key":"e_1_2_1_6_1","unstructured":"FouremanPA(1986): The TX;Y test for the detection of nondisjunction and chromosome breakage inDrosophila melanogaster. 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