{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T22:51:49Z","timestamp":1757544709958},"reference-count":12,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,7,14]],"date-time":"2006-07-14T00:00:00Z","timestamp":1152835200000},"content-version":"vor","delay-in-days":7499,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Environ. mutagen"],"published-print":{"date-parts":[[1986,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In a previous report chromate potentiated the mutagenicity of sodium azide, apparently by affecting repair and\/or replication of DNA. Further evidence in support of such a mechanism for chromate potentiation is reported here. Chromate does not react directly with azide or its major mutagenic metabolite, azidoalanine, eliminating such reactions as possible mechanisms for potentiation. Further, azide was unable to potentiate the mutagenicity of chromate in <jats:italic>Salmonella typhimurium<\/jats:italic> strain TA104, which is sensitive to chromate mutagenicity but not to azide. Thus, it appears that the potentiation is not due to an action of azide in modulating chromate mutagenicity. Finally, the interaction was not altered by deficiency in <jats:italic>recA<\/jats:italic> gene product in <jats:italic>S typhimurium<\/jats:italic> GW19, nor by enhancement of SOS repair in the pKM101 containing strain TA100. Thus, induction of <jats:italic>recA<\/jats:italic>\u2010dependent functions seems to play no role in the comutagenic actions of chromate. The simplest explanation for potentiation seems to be that chromate is able either to limit error\u2010free recovery from azide\u2010induced DNA damage or to promote error\u2010prone repair or error\u2010prone processing at sites of lesions.<\/jats:p>","DOI":"10.1002\/em.2860080507","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T22:47:39Z","timestamp":1172011659000},"page":"717-725","source":"Crossref","is-referenced-by-count":5,"title":["Chromium (VI) comutagenesis: Characterization of the interaction of K<sub>2<\/sub>CrO<sub>4<\/sub> with azide"],"prefix":"10.1002","volume":"8","author":[{"given":"James M.","family":"Lavelle","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,14]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00271960"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1218(86)90002-9"},{"key":"e_1_2_1_4_1","first-page":"311","article-title":"Chromium(VI) potentiates mutagenesis by sodium azide but not ethyl methanesulfonate","volume":"6","author":"La Velle JM","year":"1984","journal-title":"Mutat Res"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1218(84)90079-X"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","unstructured":"MangoldJB La VelleJM(1986): Synthesis and enantioselective mutagenicity of azidoalanine inSalmonella typhimurium.Chem Biol Interact(in press).","DOI":"10.1016\/0009-2797(86)90026-8"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1161(80)90166-1"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1161(75)90088-6"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0027-5107(81)90193-7"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.33.4.805-809.1977"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-7992(81)90032-4"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.73.7.2331"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0027-5107(79)90080-0"}],"container-title":["Environmental Mutagenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fem.2860080507","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/em.2860080507","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T21:33:36Z","timestamp":1697924016000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/em.2860080507"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,1]]},"references-count":12,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1986,1]]}},"alternative-id":["10.1002\/em.2860080507"],"URL":"https:\/\/doi.org\/10.1002\/em.2860080507","archive":["Portico"],"relation":{},"ISSN":["0192-2521","1930-238X"],"issn-type":[{"value":"0192-2521","type":"print"},{"value":"1930-238X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1986,1]]}}}