{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T10:03:55Z","timestamp":1789207435682,"version":"build-2803163510"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,7,14]],"date-time":"2006-07-14T00:00:00Z","timestamp":1152835200000},"content-version":"vor","delay-in-days":7134,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Environ. mutagen"],"published-print":{"date-parts":[[1987,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Three\u2010carbon chemicals (chlorinated and nonchlorinated, saturated and unsaturated, hydroxy\u2010 and oxo\u2010hydrocarbons) were assayed for genotoxicity. The sister chromatid exchange test in vitro served as the test system. Without S9 mix, the nonchlorinated solvents 1\u2010propanol, 2\u2010propanol, and 2\u2010propanone (acetone) did not increase the SCE frequencies. All chlorinated 3\u2010C hydrocarbons, except 1,2,3\u2010trichloropropane, proved to be potent SCE inducers in V79 cells without S9 mix.<\/jats:p><jats:p>In the presence of S9 mix, the results obtained with the nonchlorinated solvents were also negative, whereas 1,2,3\u2010trichloropropane was transformed to SCE\u2010inducing metabolites. The addition of S9 mix resulted in an increased SCE rate for 2,3\u2010dichloropropanol, whereas genotoxicity of 2,3\u2010dichloropropene, 1,2\u2010di\u2010chloropropane, 1,3\u2010dichloropropene, and 1,3\u2010dichloropropanone was reduced. 1,3\u2010dichloropropanol, 1,3\u2010dichloropropene, and epichlorohydrin were substantially inactivated by S9 mix in the V79\/SCE test.<\/jats:p><jats:p>It can be concluded that the reactivity of the saturated dichloro compounds in the SCE test depends on the degree of oxidation. There is no general difference between the reactivity of \u03b1,\u03b2\u2010dichloro and \u03b1,\u03c9\u2010dichloro compounds.<\/jats:p>","DOI":"10.1002\/em.2860090406","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T23:08:42Z","timestamp":1172012922000},"page":"401-410","source":"Crossref","is-referenced-by-count":43,"title":["Genotoxicity of three\u2010carbon compounds evaluated in the SCE test in vitro"],"prefix":"10.1002","volume":"9","author":[{"given":"Wilhelm","family":"von der Hude","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Scheutwinkel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrike","family":"Gramlich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte","family":"Fibler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armin","family":"Basler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,14]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1161(75)90046-1"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00292609"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1110(85)90005-3"},{"key":"e_1_2_1_5_1","first-page":"1915","article-title":"Mutagenicity of pesticides containing 1,3\u2010dichloropropene","volume":"37","author":"de Lorenzo F","year":"1977","journal-title":"Cancer Res"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.347576"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/15287398409530613"},{"key":"e_1_2_1_8_1","first-page":"922","article-title":"Forestomach tumors induced by orally administered epichlorohydrin in male Wistar rats","volume":"71","author":"Konishi Y","year":"1980","journal-title":"Gann"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/es00114a006"},{"key":"e_1_2_1_10_1","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1093\/jnci\/65.4.751","article-title":"Inhalation carcinogenicity of epichlorohydrin in non inbred Spraque\u2010Dawley rats","volume":"65","author":"Laskin S","year":"1980","journal-title":"J Natl Cancer Inst"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1110(81)90003-8"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)52451-6"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1218(81)90025-2"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1218(79)90048-X"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(80)90075-1"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf60213a036"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0015-6264(80)90062-0"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ps.2780020207"},{"key":"e_1_2_1_19_1","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1080\/15287397909529820","article-title":"Mutagenicity of halogenated and oxygenated 3\u2010carbon compounds","volume":"5","author":"Stolzenberg SJ","year":"1979","journal-title":"J Toxicol Environm Health"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/em.2860020109"},{"key":"e_1_2_1_21_1","first-page":"1433","article-title":"Carcinogenicity of halogenated olefinic and aliphatic hydrocarbons in mice","volume":"63","author":"van Duuren L","year":"1979","journal-title":"J Natl Cancer Inst"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01135595"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1218(80)90096-8"}],"container-title":["Environmental Mutagenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fem.2860090406","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/em.2860090406","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T01:19:57Z","timestamp":1697851197000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/em.2860090406"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,1]]},"references-count":22,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1987,1]]}},"alternative-id":["10.1002\/em.2860090406"],"URL":"https:\/\/doi.org\/10.1002\/em.2860090406","archive":["Portico"],"relation":{},"ISSN":["0192-2521","1930-238X"],"issn-type":[{"value":"0192-2521","type":"print"},{"value":"1930-238X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,1]]}}}