{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:21:56Z","timestamp":1777929716004,"version":"3.51.4"},"reference-count":6,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,7,14]],"date-time":"2006-07-14T00:00:00Z","timestamp":1152835200000},"content-version":"vor","delay-in-days":6769,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Environ. mutagen"],"published-print":{"date-parts":[[1988,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Seventy\u2010two chemicals were tested for their mutagenic potential in the L5178Y tk<jats:sup>+<\/jats:sup>\/<jats:sup>\u2212<\/jats:sup> mouse lymphoma cell forward mutation assay, using procedures based upon those described by Clive and Spector (Mutat Res 44:269\u2010278, 1975) and Clive et al. (Mutat Res 59:61\u2010108, 1979). Cultures were exposed to the chemicals for 4 hr, then cultured for 2 days before plating in soft agar with or without trifluorothymidine (TFT), 3 \u03bcg\/ml. The chemicals were tested at least twice. Significant responses were obtained with allyl isothiocyanate, p\u2010benzoquinone dioxime, benzyl acetate, 2\u2010biphenylamine HCl, bis(2\u2010chloro\u20101\u2010methylethyl)ether, cadmium chloride, chlordane, chlorobenzene, chlorobenzilate, 2\u2010chloroethanol, chlorothalonil, cytarabine\u2010HCl, p,p\u2032\u2010DDE, diazinon, 2,6\u2010dichloro\u2010p\u2010phenylenediamine, N,N\u2010diethylthiourea, diglycidylresorcinol ether, 2,4\u2010dimethoxy aniline\u2010HCl, disperse yellow 3, endosulfan, 1,2\u2010epoxyhexa\u2010decane, ethyl acrylate, ethyl benzene, ethylene thiourea, F D and C yellow Number 6, furan, heptachlor, isophorone, mercuric chloride, 4,4\u2032\u2010methylenedianiline 2 HCl, methyl viologen, nickel sulfate\u20106H<jats:sub>2<\/jats:sub>O, 4,4\u2032\u2010oxydianiline, pentachloroethane, piperonyl butoxide, propyl gallate, quinoline, rotenone, 2,4,5,6\u2010tetrachloro\u20104\u2010nitro\u2010anisole, 1,1,1,2\u2010tetrachloroethane, trichlorfon, 2,4,6\u2010trichlorophenol, 2,4,5\u2010trimetho\u2010xybenzaldehyde, 1,1,3\u2010trimethyl\u20102\u2010thiourea, 1\u2010vinyl\u20103\u2010cyclopetene dioxide, vinyl toluene, and ziram.<\/jats:p><jats:p>Apart from 2\u2010biphenylamine\u2010HCl, 2\u2010chloroethanol, disperse yellow 3, ethylene thiourea, FD and C yellow number 6, phenol, and 1,1,2\u2010tetrachloroethane, rat liver S9 mix was not a requirement for these compounds.<\/jats:p><jats:p>Chemicals not identified as mutagens were acid red, 11\u2010aminoundecanoic acid, boric acid, 5\u2010chloro\u2010o\u2010toluidine, coumaphos, cyclohexanone, decabromodiphenyl oxide, di(2\u2010ethylhexyl)adipate, ferric chloride, fluometuron, melamine, monuron, phenesterin, phthalimide, reserpine, sodium dodecyl sulfate, 4,4\u2010sulfonyldianiline, tetrachloroethylene, and zearalenone.<\/jats:p><jats:p>The assay was incapable of providing a clear indication of whether some chemicals were mutagens; these were benzyl alcohol, 1,4\u2010dichlorobenzene, phenol, succinic acid\u20102,2\u2010dimethyl hydrazide, and toluene.<\/jats:p>","DOI":"10.1002\/em.2860120111","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T23:08:31Z","timestamp":1172012911000},"page":"85-154","source":"Crossref","is-referenced-by-count":268,"title":["Responses of the l5178y tk<sup>+<\/sup>\/tk<sup>\u2212<\/sup> mouse lymphoma cell forward mutation assay: III. 72 Coded chemicals"],"prefix":"10.1002","volume":"12","author":[{"given":"Douglas B.","family":"McGregor","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alison","family":"Brown","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pamela","family":"Cattanach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian","family":"Edwards","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas","family":"McBride","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Colin","family":"Riach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William J.","family":"Caspary","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,14]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"215","volume-title":"Statistical Inference Under Order Restrictions: The Theory and Application of Isotonic Regression","author":"Barlow RE","year":"1972"},{"issue":"13","key":"e_1_2_1_3_1","article-title":"Evaluations of the L5178Y mouse lymphoma cell mutagenesis assay","volume":"12","author":"Caspary WJ","year":"1988","journal-title":"Environ Mol Mutagen"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1218(87)90031-0"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0027-5107(77)90084-7"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0027-5107(79)90195-7"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1161(83)90231-5"}],"container-title":["Environmental Mutagenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fem.2860120111","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/em.2860120111","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T06:43:13Z","timestamp":1697870593000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/em.2860120111"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,1]]},"references-count":6,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1988,1]]}},"alternative-id":["10.1002\/em.2860120111"],"URL":"https:\/\/doi.org\/10.1002\/em.2860120111","archive":["Portico"],"relation":{},"ISSN":["0192-2521","1930-238X"],"issn-type":[{"value":"0192-2521","type":"print"},{"value":"1930-238X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,1]]}}}