{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T16:54:48Z","timestamp":1783702488987,"version":"3.55.0"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T00:00:00Z","timestamp":1776988800000},"content-version":"vor","delay-in-days":54,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Environ and Mol Mutagen"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Potassium bromate (KBrO\n                    <jats:sub>3<\/jats:sub>\n                    ), a probable human carcinogen, is generated as a disinfection by\u2010product during ozonation of water and is also used as a flour maturing agent. It has been shown to induce oxidative damage and subsequent tissue\u2010toxicity in individuals who get exposed to it. Previously, we have reported that KBrO\n                    <jats:sub>3<\/jats:sub>\n                    induces oxidative stress and subsequent intestinal toxicity, as is evident from DNA damage and the histological studies. In the present study, the protective efficacy of dietary antioxidant vitamin C on KBrO\n                    <jats:sub>3<\/jats:sub>\n                    \u2010induced intestinal toxicity has been explored. Administration of KBrO\n                    <jats:sub>3<\/jats:sub>\n                    led to a decrease (almost 1.5 fold) in the brush border membrane enzymatic activities. The oxidative reductive homeostasis of the intestine was greatly affected, as reflected by the severe alterations in the antioxidant enzymatic system, besides altering the carbohydrate metabolism too. There was also an increase in DNA damage (+1.5 fold) and DNA\u2010protein cross\u2010linking (+2 fold). However, pretreatment with vitamin C resulted in significant attenuation\/modulation in all these parameters. The biochemical studies were supported by the histological studies showing extensive intestinal damage in KBrO\n                    <jats:sub>3<\/jats:sub>\n                    \u2010treated animals and greatly reduced tissue injury in the vitamin C\u2009+\u2009KBrO\n                    <jats:sub>3<\/jats:sub>\n                    group. These results show that vitamin C mitigates bromate\u2010induced intestinal toxic insult and oxidative damage by improving antioxidant defense, tissue integrity, and energy metabolism and thus can be used as a therapeutic\/protective agent against bromate and its related compounds.\n                  <\/jats:p>","DOI":"10.1002\/em.70045","type":"journal-article","created":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T06:30:44Z","timestamp":1777098644000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Vitamin C Regulates Redox Homeostasis and Mitigates Potassium Bromate\u2010Induced Oxidative Injury to Rat Intestine"],"prefix":"10.1002","volume":"67","author":[{"given":"Saima","family":"Nazir","sequence":"first","affiliation":[{"name":"Department of Biotechnology Mewar University  Chittorgarh Rajasthan India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mir Kaisar","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Life Sciences Aligarh Muslim University (AMU)  Aligarh India"},{"name":"Department of Biochemistry Government Medical College  Doda Jammu and Kashmir India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Zubair\u2010Ul\u2010Nazir","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Sher\u2010I\u2010Kashmir Institute of Medical Sciences (SKIMS)  Srinagar India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,24]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/tox.20780"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2012.09.001"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/tox.22045"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2013.01.008"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-020-02113-y"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules30030748"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/1559325819885782"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2025.1551062"},{"key":"e_1_2_13_10_1","volume-title":"Theory and Practice of Histological Techniques","author":"Bancroft J. 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