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In this study, we used a chronic drinking water exposure model in mice (90\u2009days) and subsequently evaluated oocyte developmental competence in\u00a0vitro. A chronic drinking water exposure model with environmentally relevant concentrations of HAL\u2010DBPs was established to systematically evaluate their effects on oocyte developmental competence and to investigate the protective role of the natural antioxidant resveratrol (RES). The results showed that HAL\u2010DBPs exposure significantly reduced oocyte maturation rate and early embryonic development potential, leading to spindle disorganization, chromosomal misalignment, and disruption of the actin cytoskeleton. Moreover, HAL\u2010DBPs induced mitochondrial membrane potential loss, lipid metabolic disorder, impaired autophagy\u2010lysosomal flux, excessive ROS accumulation, DNA damage, and apoptosis. Notably, RES cotreatment markedly alleviated these adverse effects by restoring mitochondrial function and redox homeostasis, reducing DNA damage and apoptosis, and preserving cytoskeletal integrity. Collectively, this study provides the first evidence that HAL\u2010DBPs directly impair female germ cells through mitochondria\u2010dependent oxidative stress mechanisms and proposes RES as a promising natural antioxidant intervention to mitigate reproductive toxicity associated with drinking water disinfection by\u2010products.<\/jats:p>","DOI":"10.1002\/em.70070","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T22:36:03Z","timestamp":1782858963000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Resveratrol Mitigates Haloacetaldehyde Disinfection By\u2010Products (\n                    <scp>HAL<\/scp>\n                    \u2010\n                    <scp>DBPs<\/scp>\n                    )\u2010Induced Oocyte Developmental Toxicity via Mitochondria\u2010Dependent 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