{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T15:00:20Z","timestamp":1791212420573,"version":"4.1.0"},"reference-count":138,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2013,6,6]],"date-time":"2013-06-06T00:00:00Z","timestamp":1370476800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"},{"start":{"date-parts":[[2013,6,6]],"date-time":"2013-06-06T00:00:00Z","timestamp":1370476800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"NIH\u2013GMS R01s","award":["GM097194"],"award-info":[{"award-number":["GM097194"]}]},{"name":"NIH\u2013GMS R01s","award":["GM099844"],"award-info":[{"award-number":["GM099844"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["EMBO Mol Med"],"published-print":{"date-parts":[[2013,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Lipid droplets (LDs) are dynamic, cytosolic lipid\u2010storage organelles found in nearly all cell types. Too many or too few LDs during excess or deficient fat storage lead to many different human diseases. Recent insights into LD biology and LD protein functions shed new light on mechanisms underlying those metabolic pathologies. These findings will likely provide opportunities for treatment of diseases associated with too much or too little fat.<\/jats:p>","DOI":"10.1002\/emmm.201100671","type":"journal-article","created":{"date-parts":[[2013,6,6]],"date-time":"2013-06-06T06:53:33Z","timestamp":1370501613000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":458,"title":["Balancing the fat: lipid droplets and human disease"],"prefix":"10.1038","volume":"5","author":[{"given":"Natalie","family":"Krahmer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Robert V.","family":"Farese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias C.","family":"Walther","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,6,6]]},"reference":[{"key":"BFEMMM201100671_CR1","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1172\/JCI9021","volume":"105","author":"M Accad","year":"2000","unstructured":"Accad M, Smith SJ, Newland DL, Sanan DA, King LE, Jr., Linton MF, Fazio S, Farese RV, Jr. (2000) Massive xanthomatosis and altered composition of atherosclerotic lesions in hyperlipidemic mice lacking acyl CoA:cholesterol acyltransferase 1. J Clin Invest 105: 711-719","journal-title":"J Clin Invest"},{"key":"BFEMMM201100671_CR2","doi-asserted-by":"crossref","first-page":"3251","DOI":"10.1210\/jc.2004-2194","volume":"90","author":"DC Adler\u2010Wailes","year":"2005","unstructured":"Adler\u2010Wailes DC, Liu H, Ahmad F, Feng N, Londos C, Manganiello V, Yanovski JA (2005) Effects of the human immunodeficiency virus\u2010protease inhibitor, ritonavir, on basal and catecholamine\u2010stimulated lipolysis. J Clin Endocrinol Metab 90: 3251-3261","journal-title":"J Clin Endocrinol Metab"},{"key":"BFEMMM201100671_CR3","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1093\/hmg\/ddg213","volume":"12","author":"AK Agarwal","year":"2003","unstructured":"Agarwal AK, Fryns JP, Auchus RJ, Garg A (2003) Zinc metalloproteinase, ZMPSTE24, is mutated in mandibuloacral dysplasia. Hum Mol Genet 12: 1995-2001","journal-title":"Hum Mol Genet"},{"key":"BFEMMM201100671_CR4","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1038\/sj.ijo.0802487","volume":"28","author":"AK Agarwal","year":"2004","unstructured":"Agarwal AK, Barnes RI, Garg A (2004) Genetic basis of congenital generalized lipodystrophy. Int J Obes Relat Metab Disord 28: 336-339","journal-title":"Int J Obes Relat Metab Disord"},{"key":"BFEMMM201100671_CR5","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.tem.2009.06.002","volume":"20","author":"M Ahmadian","year":"2009","unstructured":"Ahmadian M, Duncan RE, Sul HS (2009) The skinny on fat: lipolysis and fatty acid utilization in adipocytes. Trends Endocrinol Metab 20: 424-428","journal-title":"Trends Endocrinol Metab"},{"key":"BFEMMM201100671_CR6","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1017\/S0029665109990267","volume":"68","author":"C Bing","year":"2009","unstructured":"Bing C, Trayhurn P (2009) New insights into adipose tissue atrophy in cancer cachexia. Proc Nutr Soc 68: 385-392","journal-title":"Proc Nutr Soc"},{"key":"BFEMMM201100671_CR7","doi-asserted-by":"crossref","first-page":"10747","DOI":"10.1021\/bi1013003","volume":"49","author":"D Binns","year":"2010","unstructured":"Binns D, Lee S, Hilton CL, Jiang QX, Goodman JM (2010) Seipin is a discrete homooligomer. Biochemistry 49: 10747-10755","journal-title":"Biochemistry"},{"key":"BFEMMM201100671_CR8","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.cmet.2011.07.015","volume":"14","author":"KE Bornfeldt","year":"2011","unstructured":"Bornfeldt KE, Tabas I (2011) Insulin resistance, hyperglycemia, and atherosclerosis. Cell Metab 14: 575-585","journal-title":"Cell Metab"},{"key":"BFEMMM201100671_CR9","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1111\/j.1600-0854.2008.00767.x","volume":"9","author":"S Boulant","year":"2008","unstructured":"Boulant S, Douglas MW, Moody L, Budkowska A, Targett\u2010Adams P, McLauchlan J (2008) Hepatitis C virus core protein induces lipid droplet redistribution in a microtubule\u2010 and dynein\u2010dependent manner. Traffic 9: 1268-1282","journal-title":"Traffic"},{"key":"BFEMMM201100671_CR10","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1016\/j.biochi.2009.01.011","volume":"91","author":"E Boutet","year":"2009","unstructured":"Boutet E, El Mourabit H, Prot M, Nemani M, Khallouf E, Colard O, Maurice M, Durand\u2010Schneider AM, Chretien Y, Gres S et al (2009) Seipin deficiency alters fatty acid Delta9 desaturation and lipid droplet formation in Berardinelli\u2010Seip congenital lipodystrophy. Biochimie 91: 796-803","journal-title":"Biochimie"},{"key":"BFEMMM201100671_CR11","doi-asserted-by":"crossref","first-page":"9344","DOI":"10.1016\/S0021-9258(19)70568-7","volume":"255","author":"MS Brown","year":"1980","unstructured":"Brown MS, Ho YK, Goldstein JL (1980) The cholesteryl ester cycle in macrophage foam cells \u2013 continual hydrolysis and re\u2010esterification of cytoplasmic cholesteryl esters. J Biol Chem 255: 9344-9352","journal-title":"J Biol Chem"},{"key":"BFEMMM201100671_CR12","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1476-511X-7-3","volume":"7","author":"H Cao","year":"2008","unstructured":"Cao H, Alston L, Ruschman J, Hegele RA (2008) Heterozygous CAV1 frameshift mutations (MIM 601047) in patients with atypical partial lipodystrophy and hypertriglyceridemia. Lipids Health Dis 7: 3","journal-title":"Lipids Health Dis"},{"key":"BFEMMM201100671_CR13","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1016\/j.biocel.2011.03.002","volume":"43","author":"J Capeau","year":"2011","unstructured":"Capeau J, Vigouroux C, Caron\u2010Debarle M, Le Dour C, Magre J (2011) Molecular mechanisms of human lipodystrophies: from adipocyte lipid droplet to oxidative stress and lipotoxicity. Int J Biochem Cell Biol 43: 862-876","journal-title":"Int J Biochem Cell Biol"},{"key":"BFEMMM201100671_CR14","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.2337\/diabetes.50.6.1378","volume":"50","author":"M Caron","year":"2001","unstructured":"Caron M, Auclair R, Vigouroux C, Glorian M, Forest C, Capeau J (2001) The HIV protease inhibitor indinavir impairs sterol regulatory element\u2010binding protein\u20101 intranuclear localization, inhibits preadipocyte differentiation, and induces insulin resistance. Diabetes 50: 1378-1388","journal-title":"Diabetes"},{"key":"BFEMMM201100671_CR15","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1128\/MCB.26.3.1063-1076.2006","volume":"26","author":"BHJ Chang","year":"2006","unstructured":"Chang BHJ, Li L, Paul A, Taniguchi S, Nannegari V, Heird WC, Chan L (2006) Protection against fatty liver but normal adipogenesis in mice lacking adipose differentiation\u2010related protein. Mol Cell Biol 26: 1063-1076","journal-title":"Mol Cell Biol"},{"key":"BFEMMM201100671_CR16","doi-asserted-by":"crossref","first-page":"4552","DOI":"10.1210\/en.2009-0236","volume":"150","author":"W Chen","year":"2009","unstructured":"Chen W, Yechoor VK, Chang BH, Li MV, March KL, Chan L (2009) The human lipodystrophy gene product Berardinelli\u2010Seip congenital lipodystrophy 2\/seipin plays a key role in adipocyte differentiation. Endocrinology 150: 4552-4561","journal-title":"Endocrinology"},{"key":"BFEMMM201100671_CR17","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1038\/nature07976","volume":"458","author":"MJ Czaja","year":"2009","unstructured":"Czaja MJ, Singh R, Kaushik S, Wang YJ, Xiang YQ, Novak I, Komatsu M, Tanaka K, Cuervo AM (2009) Autophagy regulates lipid metabolism. Nature 458: 1131-1135","journal-title":"Nature"},{"key":"BFEMMM201100671_CR18","doi-asserted-by":"crossref","first-page":"3032","DOI":"10.2337\/diabetes.54.10.3032","volume":"54","author":"I Dahlman","year":"2005","unstructured":"Dahlman I, Kaaman M, Jiao H, Kere J, Laakso M, Arner P (2005) The CIDEA gene V115F polymorphism is associated with obesity in Swedish subjects. Diabetes 54: 3032-3034","journal-title":"Diabetes"},{"key":"BFEMMM201100671_CR19","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1126\/science.1198973","volume":"333","author":"SK Das","year":"2011","unstructured":"Das SK, Eder S, Schauer S, Diwoky C, Temmel H, Guertl B, Gorkiewicz G, Tamilarasan KP, Kumari P, Trauner M, et al (2011) Adipose triglyceride lipase contributes to cancer\u2010associated cachexia. Science 333: 233-238","journal-title":"Science"},{"key":"BFEMMM201100671_CR20","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1172\/JCI9842","volume":"105","author":"K El\u2010Haschimi","year":"2000","unstructured":"El\u2010Haschimi K, Pierroz DD, Hileman SM, Bjorbaek C, Flier JS (2000) Two defects contribute to hypothalamic leptin resistance in mice with diet\u2010induced obesity. J Clin Invest 105: 1827-1832","journal-title":"J Clin Invest"},{"key":"BFEMMM201100671_CR21","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/S1388-1981(00)00144-X","volume":"1529","author":"RV Farese","year":"2000","unstructured":"Farese RV, Buhman KF, Accad M (2000) Mammalian acyl\u2010CoA: cholesterol acyltransferases. Biochim Biophys Acta 1529: 142-154","journal-title":"Biochim Biophys Acta"},{"key":"BFEMMM201100671_CR22","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.1194\/jlr.R800018-JLR200","volume":"49","author":"RV Farese","year":"2008","unstructured":"Farese RV, Yen CLE, Stone SJ, Koliwad S, Harris C (2008) DGAT enzymes and triacylglycerol biosynthesis. J Lipid Res 49: 2283-2301","journal-title":"J Lipid Res"},{"key":"BFEMMM201100671_CR23","doi-asserted-by":"crossref","first-page":"5352","DOI":"10.1074\/jbc.M805768200","volume":"284","author":"RV Farese","year":"2009","unstructured":"Farese RV, Stone SJ, Levin MC, Zhou P, Han JY, Walther TC (2009) The endoplasmic reticulum enzyme DGAT2 is found in mitochondria\u2010associated membranes and has a mitochondrial targeting signal that promotes its association with mitochondria. J Biol Chem 284: 5352-5361","journal-title":"J Biol Chem"},{"key":"BFEMMM201100671_CR24","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.cmet.2012.03.004","volume":"15","author":"RV Farese","year":"2012","unstructured":"Farese RV, Zechner R, Newgard CB, Walther TC (2012) The problem of establishing relationships between hepatic steatosis and hepatic insulin resistance. Cell Metab 15: 570-573","journal-title":"Cell Metab"},{"key":"BFEMMM201100671_CR25","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1172\/JCI10310","volume":"107","author":"S Fazio","year":"2001","unstructured":"Fazio S, Major AS, Swift LL, Gleaves LA, Accad M, Linton MF, Farese RV, Jr. (2001) Increased atherosclerosis in LDL receptor\u2010null mice lacking ACAT1 in macrophages. J Clin Invest 107: 163-171","journal-title":"J Clin Invest"},{"key":"BFEMMM201100671_CR26","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1083\/jcb.200711136","volume":"180","author":"W Fei","year":"2008","unstructured":"Fei W, Shui G, Gaeta B, Du X, Kuerschner L, Li P, Brown AJ, Wenk MR, Parton RG, Yang H (2008) Fld1p, a functional homologue of human seipin, regulates the size of lipid droplets in yeast. J Cell Biol 180: 473-482","journal-title":"J Cell Biol"},{"key":"BFEMMM201100671_CR27","doi-asserted-by":"crossref","first-page":"e1002201","DOI":"10.1371\/journal.pgen.1002201","volume":"7","author":"W Fei","year":"2011","unstructured":"Fei W, Shui G, Zhang Y, Krahmer N, Ferguson C, Kapterian TS, Lin RC, Dawes IW, Brown AJ, Li P, et al (2011) A role for phosphatidic acid in the formation of \u201csupersized\u201d lipid droplets. PLoS Genet 7: e1002201","journal-title":"PLoS Genet"},{"key":"BFEMMM201100671_CR28","doi-asserted-by":"crossref","first-page":"973s","DOI":"10.3945\/ajcn.2008.26788B","volume":"89","author":"JM Friedman","year":"2009","unstructured":"Friedman JM (2009) Leptin at 14 y of age: an ongoing story. Am J Clin Nutr 89: 973s-979s","journal-title":"Am J Clin Nutr"},{"key":"BFEMMM201100671_CR29","doi-asserted-by":"crossref","first-page":"S349","DOI":"10.1016\/S0168-8278(08)60933-2","volume":"48","author":"H Fujii","year":"2008","unstructured":"Fujii H, Ikura Y, Iezzoni JC, Park S, Itabe H, Kawada N, Ueda M, Caldwell SH (2008) Expression of perilipin and adipophilin in human nonalcoholic fatty liver disease and their relation to oxidative damage. J Hepatol 48: S349-S349","journal-title":"J Hepatol"},{"key":"BFEMMM201100671_CR30","doi-asserted-by":"crossref","first-page":"11082","DOI":"10.1074\/jbc.M509612200","volume":"281","author":"SE Gale","year":"2006","unstructured":"Gale SE, Frolov A, Han X, Bickel PE, Cao L, Bowcock A, Schaffer JE, Ory DS (2006) A regulatory role for 1\u2010acylglycerol\u20103\u2010phosphate\u2010O\u2010acyltransferase 2 in adipocyte differentiation. J Biol Chem 281: 11082-11089","journal-title":"J Biol Chem"},{"key":"BFEMMM201100671_CR31","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1056\/NEJMoa1007487","volume":"364","author":"S Gandotra","year":"2011","unstructured":"Gandotra S, Le Dour C, Bottomley W, Cervera P, Giral P, Reznik Y, Charpentier G, Auclair M, Delepine M, Barroso I, et al (2011) Perilipin deficiency and autosomal dominant partial lipodystrophy. N Engl J Med 364: 740-748","journal-title":"N Engl J Med"},{"key":"BFEMMM201100671_CR32","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1056\/NEJMra025261","volume":"350","author":"A Garg","year":"2004","unstructured":"Garg A (2004) Medical progress \u2013 acquired and inherited lipodystrophies. N Engl J Med 350: 1220-1234","journal-title":"N Engl J Med"},{"key":"BFEMMM201100671_CR33","doi-asserted-by":"crossref","first-page":"3313","DOI":"10.1210\/jc.2011-1159","volume":"96","author":"A Garg","year":"2011","unstructured":"Garg A (2011) Clinical review#: lipodystrophies: genetic and acquired body fat disorders. J Clin Endocrinol Metab 96: 3313-3325","journal-title":"J Clin Endocrinol Metab"},{"key":"BFEMMM201100671_CR34","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.bbalip.2008.12.014","volume":"1791","author":"A Garg","year":"2009","unstructured":"Garg A, Agarwal AK (2009) Lipodystrophies: disorders of adipose tissue biology. Biochim Biophys Acta 1791: 507-513","journal-title":"Biochim Biophys Acta"},{"key":"BFEMMM201100671_CR35","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1126\/science.1096706","volume":"304","author":"S George","year":"2004","unstructured":"George S, Rochford JJ, Wolfrum C, Gray SL, Schinner S, Wilson JC, Soos MA, Murgatroyd PR, Williams RM, Acerini CL, et al (2004) A family with severe insulin resistance and diabetes due to a mutation in AKT2. Science 304: 1325-1328","journal-title":"Science"},{"key":"BFEMMM201100671_CR36","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1194\/jlr.M300162-JLR200","volume":"44","author":"S Ghosh","year":"2003","unstructured":"Ghosh S, St Clair RW, Rudel LL (2003) Mobilization of cytoplasmic CE droplets by overexpression of human macrophage cholesteryl ester hydrolase. J Lipid Res 44: 1833-1840","journal-title":"J Lipid Res"},{"key":"BFEMMM201100671_CR37","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1097\/MOL.0b013e328328d0bb","volume":"20","author":"J Gong","year":"2009","unstructured":"Gong J, Sun Z, Li P (2009) CIDE proteins and metabolic disorders. Curr Opin Lipidol 20: 121-126","journal-title":"Curr Opin Lipidol"},{"key":"BFEMMM201100671_CR38","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1083\/jcb.201104142","volume":"195","author":"JY Gong","year":"2011","unstructured":"Gong JY, Sun ZQ, Wu LZ, Xu WY, Schieber N, Xu DJ, Shui GH, Yang HY, Parton RG, Li P (2011) Fsp27 promotes lipid droplet growth by lipid exchange and transfer at lipid droplet contact sites. J Cell Biol 195: 953-963","journal-title":"J Cell Biol"},{"key":"BFEMMM201100671_CR39","doi-asserted-by":"crossref","first-page":"20890","DOI":"10.1073\/pnas.0704154104","volume":"104","author":"JM Goodman","year":"2007","unstructured":"Goodman JM, Szymanski KM, Binns D, Bartz R, Grishin NV, Li WP, Agarwal AK, Garg A, Anderson RGW (2007) The lipodystrophy protein seipin is found at endoplasmic reticulum lipid droplet junctions and is important for droplet morphology. Proc Natl Acad Sci USA 104: 20890-20895","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMMM201100671_CR40","doi-asserted-by":"crossref","first-page":"2102","DOI":"10.1172\/JCI46069","volume":"121","author":"AS Greenberg","year":"2011","unstructured":"Greenberg AS, Coleman RA, Kraemer FB, McManaman JL, Obin MS, Puri V, Yan QW, Miyoshi H, Mashek DG (2011) The role of lipid droplets in metabolic disease in rodents and humans. J Clin Invest 121: 2102-2110","journal-title":"J Clin Invest"},{"key":"BFEMMM201100671_CR41","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/nrm2391","volume":"9","author":"A Guilherme","year":"2008","unstructured":"Guilherme A, Virbasius JV, Puri V, Czech MP (2008) Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes. Nat Rev Mol Cell Biol 9: 367-377","journal-title":"Nat Rev Mol Cell Biol"},{"key":"BFEMMM201100671_CR42","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1038\/nature06928","volume":"453","author":"Y Guo","year":"2008","unstructured":"Guo Y, Walther TC, Rao M, Stuurman N, Goshima G, Terayama K, Wong JS, Vale RD, Walter P, Farese RV (2008) Functional genomic screen reveals genes involved in lipid\u2010droplet formation and utilization. Nature 453: 657-661","journal-title":"Nature"},{"key":"BFEMMM201100671_CR43","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1038\/nm.2439","volume":"17","author":"G Haemmerle","year":"2011","unstructured":"Haemmerle G, Moustafa T, Woelkart G, Buttner S, Schmidt A, van de Weijer T, Hesselink M, Jaeger D, Kienesberger PC, Zierler K, et al (2011) ATGL\u2010mediated fat catabolism regulates cardiac mitochondrial function via PPAR\u2010alpha and PGC\u20101. Nat Med 17: 1076-1085","journal-title":"Nat Med"},{"key":"BFEMMM201100671_CR44","doi-asserted-by":"crossref","first-page":"42615","DOI":"10.1074\/jbc.M111.285148","volume":"286","author":"C Harris","year":"2011","unstructured":"Harris C, Herker E, Farese RV, Jr., Ott M (2011) Hepatitis C virus core protein decreases lipid droplet turnover: a mechanism for core\u2010induced steatosis. J Biol Chem 286: 42615-42625","journal-title":"J Biol Chem"},{"key":"BFEMMM201100671_CR45","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.tem.2011.03.004","volume":"22","author":"E Herker","year":"2011","unstructured":"Herker E, Ott M (2011) Unique ties between hepatitis C virus replication and intracellular lipids. Trends Endocrinol Metab 22: 241-248","journal-title":"Trends Endocrinol Metab"},{"key":"BFEMMM201100671_CR46","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1038\/nm.2238","volume":"16","author":"E Herker","year":"2010","unstructured":"Herker E, Harris C, Hernandez C, Carpentier A, Kaehlcke K, Rosenberg AR, Farese RV, Jr., Ott M (2010) Efficient hepatitis C virus particle formation requires diacylglycerol acyltransferase\u20101. Nat Med 16: 1295-1298","journal-title":"Nat Med"},{"key":"BFEMMM201100671_CR47","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.cell.2007.11.042","volume":"132","author":"MM Hill","year":"2008","unstructured":"Hill MM, Bastiani M, Luetterforst R, Kirkham M, Kirkham A, Nixon SJ, Walser P, Abankwa D, Oorschot VM, Martin S, et al (2008) PTRF\u2010Cavin, a conserved cytoplasmic protein required for caveola formation and function. Cell 132: 113-124","journal-title":"Cell"},{"key":"BFEMMM201100671_CR48","doi-asserted-by":"crossref","first-page":"S53","DOI":"10.1038\/sj.ijo.0802502","volume":"27","author":"GS Hotamisligil","year":"2003","unstructured":"Hotamisligil GS (2003) Inflammatory pathways and insulin action. Int J Obes Relat Metab Disord 27 (Suppl. 3), S53-S55","journal-title":"Int J Obes Relat Metab Disord"},{"key":"BFEMMM201100671_CR49","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1126\/science.7678183","volume":"259","author":"GS Hotamisligil","year":"1993","unstructured":"Hotamisligil GS, Shargill NS, Spiegelman BM (1993) Adipose expression of tumor necrosis factor\u2010alpha: direct role in obesity\u2010linked insulin resistance. Science 259: 87-91","journal-title":"Science"},{"key":"BFEMMM201100671_CR50","doi-asserted-by":"crossref","first-page":"4067","DOI":"10.1242\/jcs.119768","volume":"125","author":"K Hsieh","year":"2012","unstructured":"Hsieh K, Lee YK, Londos C, Raaka BM, Dalen KT, Kimmel AR (2012) Perilipin family members preferentially sequester to either triacylglycerol\u2010specific or cholesteryl\u2010ester\u2010specific intracellular lipid storage droplets. J Cell Sci 125: 4067-4076","journal-title":"J Cell Sci"},{"key":"BFEMMM201100671_CR51","first-page":"3268","volume":"34","author":"Z Hua","year":"2009","unstructured":"Hua Z, Song S, Luo C, Wang J, Wang Y (2009) [Effect of angelica polysaccharides co\u2010erythropoietin on JAK2\/STAT5 signal transduction pathway in hematopoietic stem\/progenitor cells]. Zhongguo Zhong Yao Za Zhi 34: 3268-3271","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"key":"BFEMMM201100671_CR52","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1677\/JOE-10-0272","volume":"207","author":"I Huang\u2010Doran","year":"2010","unstructured":"Huang\u2010Doran I, Sleigh A, Rochford JJ, O'Rahilly S, Savage DB (2010) Lipodystrophy: metabolic insights from a rare disorder. J Endocrinol 207: 245-255","journal-title":"J Endocrinol"},{"key":"BFEMMM201100671_CR53","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1161\/CIRCRESAHA.110.226613","volume":"107","author":"M Igarashi","year":"2010","unstructured":"Igarashi M, Osuga J, Uozaki H, Sekiya M, Nagashima S, Takahashi M, Takase S, Takanashi M, Li Y, Ohta K, et al (2010) The critical role of neutral cholesterol ester hydrolase 1 in cholesterol removal from human macrophages. Circ Res 107: 1387-1395","journal-title":"Circ Res"},{"key":"BFEMMM201100671_CR54","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.bbrc.2005.08.070","volume":"336","author":"M Inoue","year":"2005","unstructured":"Inoue M, Ohtake T, Motomura W, Takahashi N, Hosoki Y, Miyoshi S, Suzuki Y, Saito H, Kohgo Y, Okumura T (2005) Increased expression of PPARgamma in high fat diet\u2010induced liver steatosis in mice. Biochem Biophys Res Commun 336: 215-222","journal-title":"Biochem Biophys Res Commun"},{"key":"BFEMMM201100671_CR55","doi-asserted-by":"crossref","first-page":"47402","DOI":"10.1074\/jbc.M404027200","volume":"279","author":"RL Jacobs","year":"2004","unstructured":"Jacobs RL, Devlin C, Tabas I, Vance DE (2004) Targeted deletion of hepatic CTP:phosphocholine cytidylyltransferase alpha in mice decreases plasma high density and very low density lipoproteins. J Biol Chem 279: 47402-47410","journal-title":"J Biol Chem"},{"key":"BFEMMM201100671_CR56","doi-asserted-by":"crossref","first-page":"e28614","DOI":"10.1371\/journal.pone.0028614","volume":"6","author":"S Jambunathan","year":"2011","unstructured":"Jambunathan S, Yin J, Khan W, Tamori Y, Puri V (2011) FSP27 promotes lipid droplet clustering and then fusion to regulate triglyceride accumulation. PLoS One 6: e28614","journal-title":"PLoS One"},{"key":"BFEMMM201100671_CR57","doi-asserted-by":"crossref","first-page":"48968","DOI":"10.1074\/jbc.M407841200","volume":"279","author":"CM Jenkins","year":"2004","unstructured":"Jenkins CM, Mancuso DJ, Yan W, Sims HF, Gibson B, Gross RW (2004) Identification, cloning, expression, and purification of three novel human calcium\u2010independent phospholipase A2 family members possessing triacylglycerol lipase and acylglycerol transacylase activities. J Biol Chem 279: 48968-48975","journal-title":"J Biol Chem"},{"key":"BFEMMM201100671_CR58","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1042\/CS20080306","volume":"116","author":"K Kantartzis","year":"2009","unstructured":"Kantartzis K, Machicao F, Machann J, Schick F, Fritsche A, Haring HU, Stefan N (2009) The DGAT2 gene is a candidate for the dissociation between fatty liver and insulin resistance in humans. Clin Sci 116: 531-537","journal-title":"Clin Sci"},{"key":"BFEMMM201100671_CR59","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1161\/01.ATV.18.3.423","volume":"18","author":"G Kellner\u2010Weibel","year":"1998","unstructured":"Kellner\u2010Weibel G, Jerome WG, Small DM, Warner GJ, Stoltenborg JK, Kearney MA, Corjay MH, Phillips MC, Rothblat GH (1998) Effects of intracellular free cholesterol accumulation on macrophage viability: a model for foam cell death. Arterioscler Thromb Vasc Biol 18: 423-431","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"BFEMMM201100671_CR60","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1194\/jlr.M800204-JLR200","volume":"50","author":"MB Khalil","year":"2009","unstructured":"Khalil MB, Sundaram M, Zhang HY, Links PH, Raven JF, Manmontri B, Sariahmetoglu M, Tran K, Reue K, Brindley DN, et al (2009) The level and compartmentalization of phosphatidate phosphatase\u20101 (lipin\u20101) control the assembly and secretion of hepatic VLDL. J Lipid Res 50: 47-58","journal-title":"J Lipid Res"},{"key":"BFEMMM201100671_CR61","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1056\/NEJMoa1001689","volume":"364","author":"AV Khera","year":"2011","unstructured":"Khera AV, Cuchel M, de la Llera\u2010Moya M, Rodrigues A, Burke MF, Jafri K, French BC, Phillips JA, Mucksavage ML, Wilensky RL, et al (2011) Cholesterol efflux capacity, high\u2010density lipoprotein function, and atherosclerosis. N Engl J Med 364: 127-135","journal-title":"N Engl J Med"},{"key":"BFEMMM201100671_CR62","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1210\/jc.2007-1328","volume":"93","author":"CA Kim","year":"2008","unstructured":"Kim CA, Delepine M, Boutet E, El Mourabit H, Le Lay S, Meier M, Nemani M, Bridel E, Leite CC, Bertola DR, et al (2008) Association of a homozygous nonsense caveolin\u20101 mutation with Berardinelli\u2010Seip congenital lipodystrophy. J Clin Endocrinol Metab 93: 1129-1134","journal-title":"J Clin Endocrinol Metab"},{"key":"BFEMMM201100671_CR63","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.cmet.2011.07.013","volume":"14","author":"N Krahmer","year":"2011","unstructured":"Krahmer N, Guo Y, Wilfling F, Hilger M, Lingrell S, Heger K, Newman HW, Schmidt\u2010Supprian M, Vance DE, Mann M, et al (2011) Phosphatidylcholine synthesis for lipid droplet expansion is mediated by localized activation of CTP:phosphocholine cytidylyltransferase. Cell Metab 14: 504-515","journal-title":"Cell Metab"},{"key":"BFEMMM201100671_CR64","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1074\/mcp.M112.020230","volume":"12","author":"N Krahmer","year":"2013","unstructured":"Krahmer N, Hilger M, Kory N, Wilfling F, Stoehr G, Mann M, Farese RV, Walther TC (2013) Protein correlation profiles identify lipid droplet proteins with high confidence. Mol Cell Proteomics 12: 1115-1126","journal-title":"Mol Cell Proteomics"},{"key":"BFEMMM201100671_CR65","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.cmet.2012.04.008","volume":"15","author":"M Kumari","year":"2012","unstructured":"Kumari M, Schoiswohl G, Chitraju C, Paar M, Cornaciu I, Rangrez AY, Wongsiriroj N, Nagy HM, Ivanova PT, Scott SA, et al (2012) Adiponutrin functions as a nutritionally regulated lysophosphatidic acid acyltransferase. Cell Metab 15: 691-702","journal-title":"Cell Metab"},{"key":"BFEMMM201100671_CR66","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.plipres.2010.10.004","volume":"50","author":"A Lass","year":"2011","unstructured":"Lass A, Zimmermann R, Oberer M, Zechner R (2011) Lipolysis \u2013 a highly regulated multi\u2010enzyme complex mediates the catabolism of cellular fat stores. Prog Lipid Res 50: 14-27","journal-title":"Prog Lipid Res"},{"key":"BFEMMM201100671_CR67","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1086\/324121","volume":"69","author":"C Lefevre","year":"2001","unstructured":"Lefevre C, Jobard F, Caux F, Bouadjar B, Karaduman A, Heilig R, Lakhdar H, Wollenberg A, Verret JL, Weissenbach J, et al (2001) Mutations in CGI\u201058, the gene encoding a new protein of the esterase\/lipase\/thioesterase subfamily, in Chanarin\u2010Dorfman syndrome. Am J Hum Genet 69: 1002-1012","journal-title":"Am J Hum Genet"},{"key":"BFEMMM201100671_CR68","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/bj3430001","volume":"343","author":"R Lehner","year":"1999","unstructured":"Lehner R, Vance DE (1999) Cloning and expression of a cDNA encoding a hepatic microsomal lipase that mobilizes stored triacylglycerol. Biochem J 343: 1-10","journal-title":"Biochem J"},{"key":"BFEMMM201100671_CR69","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1042\/bj3380761","volume":"338","author":"R Lehner","year":"1999","unstructured":"Lehner R, Cui Z, Vance DE (1999) Subcellullar localization, developmental expression and characterization of a liver triacylglycerol hydrolase. Biochem J 338: 761-768","journal-title":"Biochem J"},{"key":"BFEMMM201100671_CR70","doi-asserted-by":"crossref","first-page":"4130","DOI":"10.1172\/JCI65179","volume":"122","author":"JZ Li","year":"2012","unstructured":"Li JZ, Huang Y, Karaman R, Ivanova PT, Brown HA, Roddy T, Castro\u2010Perez J, Cohen JC, Hobbs HH (2012) Chronic overexpression of PNPLA3I148M in mouse liver causes hepatic steatosis. J Clin Invest 122: 4130-4144","journal-title":"J Clin Invest"},{"key":"BFEMMM201100671_CR71","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1172\/JCI200114611","volume":"108","author":"MP Lisanti","year":"2001","unstructured":"Lisanti MP, Razani B (2001) Caveolin\u2010deficient mice: insights into caveolar function and human disease. J Clin Invest 108: 1553-1561","journal-title":"J Clin Invest"},{"key":"BFEMMM201100671_CR72","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1194\/jlr.M600413-JLR200","volume":"48","author":"PS Liu","year":"2007","unstructured":"Liu PS, Bartz R, Li WH, Venables B, Zehmer JK, Roth MR, Welti R, Anderson RGW, Chapman KD (2007) Lipidomics reveals that adiposomes store ether lipids and mediate phospholipid traffic. J Lipid Res 48: 837-847","journal-title":"J Lipid Res"},{"key":"BFEMMM201100671_CR73","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.cmet.2008.07.008","volume":"8","author":"L Liu","year":"2008","unstructured":"Liu L, Brown D, McKee M, Lebrasseur NK, Yang D, Albrecht KH, Ravid K, Pilch PF (2008) Deletion of Cavin\/PTRF causes global loss of caveolae, dyslipidemia, and glucose intolerance. Cell Metab 8: 310-317","journal-title":"Cell Metab"},{"key":"BFEMMM201100671_CR74","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1016\/j.febslet.2006.03.040","volume":"580","author":"C Lundin","year":"2006","unstructured":"Lundin C, Nordstrom R, Wagner K, Windpassinger C, Andersson H, von Heijne G, Nilsson I (2006) Membrane topology of the human seipin protein. FEBS Lett 580: 2281-2284","journal-title":"FEBS Lett"},{"key":"BFEMMM201100671_CR75","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.cmet.2011.03.023","volume":"13","author":"YL Marcel","year":"2011","unstructured":"Marcel YL, Ouimet M, Franklin V, Mak E, Liao XH, Tabas I (2011) Autophagy regulates cholesterol efflux from macrophage foam cells via lysosomal acid lipase. Cell Metab 13: 655-667","journal-title":"Cell Metab"},{"key":"BFEMMM201100671_CR76","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.bbalip.2008.07.004","volume":"1791","author":"S Martin","year":"2009","unstructured":"Martin S, Murphy S, Parton RG (2009) Lipid droplet\u2010organelle interactions; sharing the fats. Biochim Biophys Acta 1791: 441-447","journal-title":"Biochim Biophys Acta"},{"key":"BFEMMM201100671_CR77","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1038\/82630","volume":"26","author":"J Martinez\u2010Botas","year":"2000","unstructured":"Martinez\u2010Botas J, Anderson JB, Tessier D, Lapillonne A, Chang BHJ, Quast MJ, Gorenstein D, Chen KH, Chan L (2000) Absence of perilipin results in leanness and reverses obesity in Lepr db db mice. Nat Genet 26: 474-479","journal-title":"Nat Genet"},{"key":"BFEMMM201100671_CR78","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.ymgme.2010.06.016","volume":"101","author":"M Matsuo","year":"2010","unstructured":"Matsuo M, Dwianingsih EK, Takeshima Y, Itoh K, Yamauchi Y, Awano H, Malueka RG, Nishida A, Ota M, Yagi M (2010) A Japanese child with asymptomatic elevation of serum creatine kinase shows PTRF\u2010CAVIN mutation matching with congenital generalized lipodystrophy type 4. Mol Genet Metab 101: 233-237","journal-title":"Mol Genet Metab"},{"key":"BFEMMM201100671_CR79","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.cmet.2008.03.003","volume":"7","author":"K Matsusue","year":"2008","unstructured":"Matsusue K, Kusakabe T, Noguchi T, Takiguchi S, Suzuki T, Yamano S, Gonzalez FJ (2008) Hepatic steatosis in leptin\u2010deficient mice is promoted by the PPAR gamma target gene Fsp27. Cell Metab 7: 302-311","journal-title":"Cell Metab"},{"key":"BFEMMM201100671_CR80","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1038\/ncb1631","volume":"9","author":"Y Miyanari","year":"2007","unstructured":"Miyanari Y, Atsuzawa K, Usuda N, Watashi K, Hishiki T, Zayas M, Bartenschlager R, Wakita T, Hijikata M, Shimotohno K (2007) The lipid droplet is an important organelle for hepatitis C virus production. Nat Cell Biol 9: 1089-1097","journal-title":"Nat Cell Biol"},{"key":"BFEMMM201100671_CR81","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.cell.2011.04.005","volume":"145","author":"KJ Moore","year":"2011","unstructured":"Moore KJ, Tabas I (2011) Macrophages in the pathogenesis of atherosclerosis. Cell 145: 341-355","journal-title":"Cell"},{"key":"BFEMMM201100671_CR82","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1099\/0022-1317-78-7-1527","volume":"78","author":"K Moriya","year":"1997","unstructured":"Moriya K, Yotsuyanagi H, Shintani Y, Fujie H, Ishibashi K, Matsuura Y, Miyamura T, Koike K (1997) Hepatitis C virus core protein induces hepatic steatosis in transgenic mice. J Gen Virol 78: 1527-1531","journal-title":"J Gen Virol"},{"key":"BFEMMM201100671_CR83","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/j.bbrc.2005.12.121","volume":"340","author":"W Motomura","year":"2006","unstructured":"Motomura W, Inoue M, Ohtake T, Takahashi N, Nagamine M, Tanno S, Kohgo Y, Okumura T (2006) Up\u2010regulation of ADRP in fatty liver in human and liver steatosis in mice fed with high fat diet. Biochem Biophys Res Commun 340: 1111-1118","journal-title":"Biochem Biophys Res Commun"},{"key":"BFEMMM201100671_CR84","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1007\/s00709-011-0329-7","volume":"249","author":"DJ Murphy","year":"2012","unstructured":"Murphy DJ (2012) The dynamic roles of intracellular lipid droplets: from archaea to mammals. Protoplasma 249: 541-585","journal-title":"Protoplasma"},{"key":"BFEMMM201100671_CR85","doi-asserted-by":"crossref","first-page":"9604","DOI":"10.1074\/jbc.M109.043786","volume":"285","author":"ZQ Nian","year":"2010","unstructured":"Nian ZQ, Sun ZQ, Yu LX, Toh SY, Sang JL, Li P (2010) Fat\u2010specific protein 27 undergoes ubiquitin\u2010dependent degradation regulated by triacylglycerol synthesis and lipid droplet formation. J Biol Chem 285: 9604-9615","journal-title":"J Biol Chem"},{"key":"BFEMMM201100671_CR86","first-page":"2808","volume":"118","author":"N Nishino","year":"2008","unstructured":"Nishino N, Tamori Y, Tateya S, Kawaguchi T, Shibakusa T, Mizunoya W, Inoue K, Kitazawa R, Kitazawa S, Matsuki Y, et al (2008) FSP27 contributes to efficient energy storage in murine white adipocytes by promoting the formation of unilocular lipid droplets. J Clin Invest 118: 2808-2821","journal-title":"J Clin Invest"},{"key":"BFEMMM201100671_CR87","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1056\/NEJMoa012437","volume":"346","author":"EA Oral","year":"2002","unstructured":"Oral EA, Simha V, Ruiz E, Andewelt A, Premkumar A, Snell P, Wagner AJ, DePaoli AM, Reitman ML, Taylor SI, et al (2002) Leptin\u2010replacement therapy for lipodystrophy. N Engl J Med 346: 570-578","journal-title":"N Engl J Med"},{"key":"BFEMMM201100671_CR88","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1083\/jcb.152.5.1071","volume":"152","author":"AG Ostermeyer","year":"2001","unstructured":"Ostermeyer AG, Paci JM, Zeng Y, Lublin DM, Munro S, Brown DA (2001) Accumulation of caveolin in the endoplasmic reticulum redirects the protein to lipid storage droplets. J Cell Biol 152: 1071-1078","journal-title":"J Cell Biol"},{"key":"BFEMMM201100671_CR89","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1073\/pnas.97.2.787","volume":"97","author":"J Osuga","year":"2000","unstructured":"Osuga J, Ishibashi S, Oka T, Yagyu H, Tozawa R, Fujimoto A, Shionoiri F, Yahagi N, Kraemer FB, Tsutsumi O, et al (2000) Targeted disruption of hormone\u2010sensitive lipase results in male sterility and adipocyte hypertrophy, but not in obesity. Proc Natl Acad Sci USA 97: 787-792","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMMM201100671_CR90","doi-asserted-by":"crossref","first-page":"3831","DOI":"10.1242\/jcs.070102","volume":"123","author":"RG Parton","year":"2010","unstructured":"Parton RG, Bastiani M (2010) Caveolae at a glance. J Cell Sci 123: 3831-3836","journal-title":"J Cell Sci"},{"key":"BFEMMM201100671_CR91","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1161\/CIRCRESAHA.107.168070","volume":"102","author":"A Paul","year":"2008","unstructured":"Paul A, Chang BHJ, Li L, Yechoor VK, Chan L (2008) Deficiency of adipose differentiation\u2010related protein impairs foam cell formation and protects against atherosclerosis. Circ Res 102: 1492-1501","journal-title":"Circ Res"},{"key":"BFEMMM201100671_CR92","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/83685","volume":"27","author":"M Peterfy","year":"2001","unstructured":"Peterfy M, Phan J, Xu P, Reue K (2001) Lipodystrophy in the fld mouse results from mutation of a new gene encoding a nuclear protein, lipin. Nat Genet 27: 121-124","journal-title":"Nat Genet"},{"key":"BFEMMM201100671_CR93","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.tem.2011.04.001","volume":"22","author":"PF Pilch","year":"2011","unstructured":"Pilch PF, Liu L (2011) Fat caves: caveolae, lipid trafficking and lipid metabolism in adipocytes. Trends Endocrinol Metab 22: 318-324","journal-title":"Trends Endocrinol Metab"},{"key":"BFEMMM201100671_CR94","doi-asserted-by":"crossref","first-page":"34213","DOI":"10.1074\/jbc.M707404200","volume":"282","author":"V Puri","year":"2007","unstructured":"Puri V, Konda S, Ranjit S, Aouadi M, Chawla A, Chouinard M, Chakladar A, Czech MP (2007) Fat\u2010specific protein 27, a novel lipid droplet protein that enhances triglyceride storage. J Biol Chem 282: 34213-34218","journal-title":"J Biol Chem"},{"key":"BFEMMM201100671_CR95","doi-asserted-by":"crossref","first-page":"7833","DOI":"10.1073\/pnas.0802063105","volume":"105","author":"V Puri","year":"2008","unstructured":"Puri V, Ranjit S, Konda S, Nicoloro SM, Straubhaar J, Chawla A, Chouinard M, Lin C, Burkart A, Corvera S, et al (2008) Cidea is associated with lipid droplets and insulin sensitivity in humans. Proc Natl Acad Sci USA 105: 7833-7838","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMMM201100671_CR96","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.tem.2011.03.003","volume":"22","author":"AD Quiroga","year":"2011","unstructured":"Quiroga AD, Lehner R (2011) Role of endoplasmic reticulum neutral lipid hydrolases. Trends Endocrinol Metab 22: 218-225","journal-title":"Trends Endocrinol Metab"},{"key":"BFEMMM201100671_CR97","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1038\/ijo.2009.216","volume":"34","author":"S Romeo","year":"2010","unstructured":"Romeo S, Sentinelli F, Dash S, Yeo GSH, Savage DB, Leonetti F, Capoccia D, Incani M, Maglio C, Iacovino M, et al (2010) Morbid obesity exposes the association between PNPLA3 I148M (rs738409) and indices of hepatic injury in individuals of European descent. Int J Obesity 34: 190-194","journal-title":"Int J Obesity"},{"key":"BFEMMM201100671_CR98","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1002\/emmm.200900037","volume":"1","author":"O Rubio\u2010Cabezas","year":"2009","unstructured":"Rubio\u2010Cabezas O, Puri V, Murano I, Saudek V, Semple RK, Dash S, Hyden CS, Bottomley W, Vigouroux C, Magre J, et al (2009) Partial lipodystrophy and insulin resistant diabetes in a patient with a homozygous nonsense mutation in CIDEC. EMBO Mol Med 1: 280-287","journal-title":"EMBO Mol Med"},{"key":"BFEMMM201100671_CR99","doi-asserted-by":"crossref","first-page":"910","DOI":"10.2337\/diabetes.52.4.910","volume":"52","author":"DB Savage","year":"2003","unstructured":"Savage DB, Tan GD, Acerini CL, Jebb SA, Agostini M, Gurnell M, Williams RL, Umpleby AM, Thomas EL, Bell JD, et al (2003) Human metabolic syndrome resulting from dominant\u2010negative mutations in the nuclear receptor peroxisome proliferator\u2010activated receptor\u2010gamma. Diabetes 52: 910-917","journal-title":"Diabetes"},{"key":"BFEMMM201100671_CR100","doi-asserted-by":"crossref","first-page":"E1195","DOI":"10.1152\/ajpendo.00513.2004","volume":"288","author":"SE Schadinger","year":"2005","unstructured":"Schadinger SE, Bucher NL, Schreiber BM, Farmer SR (2005) PPARgamma2 regulates lipogenesis and lipid accumulation in steatotic hepatocytes. Am J Physiol Endocrinol Metab 288: E1195-E1205","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"BFEMMM201100671_CR101","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1097\/00041433-200306000-00008","volume":"14","author":"JE Schaffer","year":"2003","unstructured":"Schaffer JE (2003) Lipotoxicity: when tissues overeat. Curr Opin Lipidol 14: 281-287","journal-title":"Curr Opin Lipidol"},{"key":"BFEMMM201100671_CR102","doi-asserted-by":"crossref","first-page":"E289","DOI":"10.1152\/ajpendo.00099.2009","volume":"297","author":"M Schweiger","year":"2009","unstructured":"Schweiger M, Lass A, Zimmermann R, Eichmann TO, Zechner R (2009) Neutral lipid storage disease: genetic disorders caused by mutations in adipose triglyceride lipase\/PNPLA2 or CGI\u201058\/ABHD5. Am J Physiol Endocrinol Metab 297: E289-E296","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"BFEMMM201100671_CR103","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.cmet.2009.08.004","volume":"10","author":"M Sekiya","year":"2009","unstructured":"Sekiya M, Osuga J, Nagashima S, Ohshiro T, Igarashi M, Okazaki H, Takahashi M, Tazoe F, Wada T, Ohta K, et al (2009) Ablation of neutral cholesterol ester hydrolase 1 accelerates atherosclerosis. Cell Metab 10: 219-228","journal-title":"Cell Metab"},{"key":"BFEMMM201100671_CR104","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.1002\/ajmg.a.33578","volume":"152A","author":"S Shastry","year":"2010","unstructured":"Shastry S, Delgado MR, Dirik E, Turkmen M, Agarwal AK, Garg A (2010) Congenital generalized lipodystrophy, type 4 (CGL4) associated with myopathy due to novel PTRF mutations. Am J Med Genet A 152A: 2245-2253","journal-title":"Am J Med Genet A"},{"key":"BFEMMM201100671_CR105","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1097\/00000658-198704000-00005","volume":"205","author":"JH Shaw","year":"1987","unstructured":"Shaw JH, Wolfe RR (1987) Fatty acid and glycerol kinetics in septic patients and in patients with gastrointestinal cancer. The response to glucose infusion and parenteral feeding. Ann Surg 205: 368-376","journal-title":"Ann Surg"},{"key":"BFEMMM201100671_CR106","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/43448","volume":"401","author":"I Shimomura","year":"1999","unstructured":"Shimomura I, Hammer RE, Ikemoto S, Brown MS, Goldstein JL (1999) Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy. Nature 401: 73-76","journal-title":"Nature"},{"key":"BFEMMM201100671_CR107","doi-asserted-by":"crossref","first-page":"11337","DOI":"10.1016\/S0021-9258(19)78130-7","volume":"269","author":"Y Shiratori","year":"1994","unstructured":"Shiratori Y, Okwu AK, Tabas I (1994) Free cholesterol loading of macrophages stimulates phosphatidylcholine biosynthesis and up\u2010regulation of CTP: phosphocholine cytidylyltransferase. J Biol Chem 269: 11337-11348","journal-title":"J Biol Chem"},{"key":"BFEMMM201100671_CR108","doi-asserted-by":"crossref","first-page":"24665","DOI":"10.1074\/jbc.273.38.24665","volume":"273","author":"SC Souza","year":"1998","unstructured":"Souza SC, de Vargas LM, Yamamoto MT, Lien P, Franciosa MD, Moss LG, Greenberg AS (1998a) Overexpression of perilipin A and B blocks the ability of tumor necrosis factor alpha to increase lipolysis in 3T3\u2010L1 adipocytes. J Biol Chem 273: 24665-24669","journal-title":"J Biol Chem"},{"key":"BFEMMM201100671_CR109","doi-asserted-by":"crossref","first-page":"691","DOI":"10.2337\/diabetes.47.4.691","volume":"47","author":"SC Souza","year":"1998","unstructured":"Souza SC, Yamamoto MT, Franciosa MD, Lien P, Greenberg AS (1998b) BRL 49653 blocks the lipolytic actions of tumor necrosis factor\u2010alpha \u2013 a potential new insulin\u2010sensitizing mechanism for thiazolidinediones. Diabetes 47: 691-695","journal-title":"Diabetes"},{"key":"BFEMMM201100671_CR110","doi-asserted-by":"crossref","first-page":"e1001324","DOI":"10.1371\/journal.pgen.1001324","volume":"7","author":"EK Speliotes","year":"2011","unstructured":"Speliotes EK, Yerges\u2010Armstrong LM, Wu J, Hernaez R, Kim LJ, Palmer CD, Gudnason V, Eiriksdottir G, Garcia ME, Launer LJ, et al (2011) Genome\u2010wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits. PLoS Genet 7: e1001324","journal-title":"PLoS Genet"},{"key":"BFEMMM201100671_CR111","doi-asserted-by":"crossref","first-page":"5352","DOI":"10.1074\/jbc.M805768200","volume":"284","author":"SJ Stone","year":"2009","unstructured":"Stone SJ, Levin MC, Zhou P, Han JY, Walther TC, Farese RV (2009) The endoplasmic reticulum enzyme DGAT2 is found in mitochondria\u2010associated membranes and has a mitochondrial targeting signal that promotes its association with mitochondria. J Biol Chem 284: 5352-5361","journal-title":"J Biol Chem"},{"key":"BFEMMM201100671_CR112","doi-asserted-by":"crossref","first-page":"1936","DOI":"10.1002\/hep.22268","volume":"47","author":"BK Straub","year":"2008","unstructured":"Straub BK, Stoeffel P, Heid H, Zimbelmann R, Schirmacher P (2008) Differential pattern of lipid droplet\u2010associated proteins and de novo perilipin expression in hepatocyte steatogenesis. Hepatology 47: 1936-1946","journal-title":"Hepatology"},{"key":"BFEMMM201100671_CR113","doi-asserted-by":"crossref","first-page":"2373","DOI":"10.1161\/01.CIR.0000164236.19860.13","volume":"111","author":"YR Su","year":"2005","unstructured":"Su YR, Dove DE, Major AS, Hasty AH, Boone B, Linton MF, Fazio S (2005) Reduced ABCA1\u2010mediated cholesterol efflux and accelerated atherosclerosis in apolipoprotein E\u2010deficient mice lacking macrophage\u2010derived ACAT1. Circulation 111: 2373-2381","journal-title":"Circulation"},{"key":"BFEMMM201100671_CR114","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.tem.2012.09.005","volume":"24","author":"Z Sun","year":"2013","unstructured":"Sun Z, Lazar MA (2013) Dissociating fatty liver and diabetes. Trends Endocrinol Metab 24: 4-12","journal-title":"Trends Endocrinol Metab"},{"key":"BFEMMM201100671_CR115","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1083\/jcb.200307081611093","volume":"162","author":"C Sztalyrd","year":"2003","unstructured":"Sztalyrd C, Xu GH, Dorward H, Tansey JT, Contreras JA, Kimmel AR, Londos C (2003) Perilipin A is essential for the translocation of hormone\u2010sensitive lipase during lipolytic activation (vol 161, pg 1093, 2003). J Cell Biol 162: 353-353","journal-title":"J Cell Biol"},{"key":"BFEMMM201100671_CR116","doi-asserted-by":"crossref","first-page":"20890","DOI":"10.1073\/pnas.0704154104","volume":"104","author":"KM Szymanski","year":"2007","unstructured":"Szymanski KM, Binns D, Bartz R, Grishin NV, Li WP, Agarwal AK, Garg A, Anderson RG, Goodman JM (2007) The lipodystrophy protein seipin is found at endoplasmic reticulum lipid droplet junctions and is important for droplet morphology. Proc Natl Acad Sci USA 104: 20890-20895","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMMM201100671_CR117","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/S1388-1981(00)00146-3","volume":"1529","author":"I Tabas","year":"2000","unstructured":"Tabas I (2000) Cholesterol and phospholipid metabolism in macrophages. Biochim Biophys Acta 1529: 164-174","journal-title":"Biochim Biophys Acta"},{"key":"BFEMMM201100671_CR118","doi-asserted-by":"crossref","first-page":"6494","DOI":"10.1073\/pnas.101042998","volume":"98","author":"JT Tansey","year":"2001","unstructured":"Tansey JT, Sztalryd C, Gruia\u2010Gray J, Roush DL, Zee JV, Gavrilova O, Reitman ML, Deng CX, Li C, Kimmel AR, et al (2001) Perilipin ablation results in a lean mouse with aberrant adipocyte lipolysis, enhanced leptin production, and resistance to diet\u2010induced obesity. Proc Natl Acad Sci USA 98: 6494-6499","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMMM201100671_CR119","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.ceb.2008.05.009","volume":"20","author":"C Thiele","year":"2008","unstructured":"Thiele C, Spandl J (2008) Cell biology of lipid droplets. Curr Opin Cell Biol 20: 378-385","journal-title":"Curr Opin Cell Biol"},{"key":"BFEMMM201100671_CR120","doi-asserted-by":"crossref","first-page":"e1001364","DOI":"10.1371\/journal.pgen.1001364","volume":"7","author":"Y Tian","year":"2011","unstructured":"Tian Y, Bi J, Shui G, Liu Z, Xiang Y, Liu Y, Wenk MR, Yang H, Huang X (2011) Tissue\u2010autonomous function of Drosophila seipin in preventing ectopic lipid droplet formation. PLoS Genet 7: e1001364","journal-title":"PLoS Genet"},{"key":"BFEMMM201100671_CR121","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1038\/nrc927","volume":"2","author":"MJ Tisdale","year":"2002","unstructured":"Tisdale MJ (2002) Cachexia in cancer patients. Nat Rev Cancer 2: 862-871","journal-title":"Nat Rev Cancer"},{"key":"BFEMMM201100671_CR122","first-page":"340","volume":"20","author":"MJ Tisdale","year":"2005","unstructured":"Tisdale MJ (2005) Molecular pathways leading to cancer cachexia. Physiology (Bethesda) 20: 340-348","journal-title":"Physiology (Bethesda)"},{"key":"BFEMMM201100671_CR123","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.physbeh.2007.11.049","volume":"94","author":"NA van Herpen","year":"2008","unstructured":"van Herpen NA, Schrauwen\u2010Hinderling VB (2008) Lipid accumulation in non\u2010adipose tissue and lipotoxicity. Physiol Behav 94: 231-241","journal-title":"Physiol Behav"},{"key":"BFEMMM201100671_CR124","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1136\/jmg.39.10.722","volume":"39","author":"L Van Maldergem","year":"2002","unstructured":"Van Maldergem L, Magre J, Khallouf TE, Gedde\u2010Dahl T, Jr., Delepine M, Trygstad O, Seemanova E, Stephenson T, Albott CS, Bonnici F, et al (2002) Genotype\u2010phenotype relationships in Berardinelli\u2010Seip congenital lipodystrophy. J Med Genet 39: 722-733","journal-title":"J Med Genet"},{"key":"BFEMMM201100671_CR125","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1016\/j.biocel.2011.03.002","volume":"43","author":"C Vigouroux","year":"2011","unstructured":"Vigouroux C, Caron\u2010Debarle M, Le Dour C, Magre J, Capeau J (2011) Molecular mechanisms of human lipodystrophies: from adipocyte lipid droplet to oxidative stress and lipotoxicity. Int J Biochem Cell Biol 43: 862-876","journal-title":"Int J Biochem Cell Biol"},{"key":"BFEMMM201100671_CR126","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.bbalip.2009.12.006","volume":"1801","author":"S Virtue","year":"2010","unstructured":"Virtue S, Vidal\u2010Puig A (2010) Adipose tissue expandability, lipotoxicity and the Metabolic Syndrome \u2013 an allostatic perspective. Biochim Biophys Acta 1801: 338-349","journal-title":"Biochim Biophys Acta"},{"key":"BFEMMM201100671_CR127","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1146\/annurev-biochem-061009-102430","volume":"81","author":"TC Walther","year":"2012","unstructured":"Walther TC, Farese RV, Jr. (2012) Lipid droplets and cellular lipid metabolism. Annu Rev Biochem 81: 687-714","journal-title":"Annu Rev Biochem"},{"key":"BFEMMM201100671_CR128","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.devcel.2013.01.013","volume":"24","author":"F Wilfling","year":"2013","unstructured":"Wilfling F, Wang H, Haas JT, Krahmer N, Gould TJ, Uchida A, Cheng JX, Graham M, Christiano R, Frohlich F, et al (2013) Triacylglycerol synthesis enzymes mediate lipid droplet growth by relocalizing from the ER to lipid droplets. Dev Cell 24: 384-399","journal-title":"Dev Cell"},{"key":"BFEMMM201100671_CR129","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1083\/jcb.201201139","volume":"198","author":"NY Xu","year":"2012","unstructured":"Xu NY, Zhang SBO, Cole RA, McKinney SA, Guo FL, Haas JT, Bobba S, Farese RV, Mak HY (2012) The FATP1\u2010DGAT2 complex facilitates lipid droplet expansion at the ER\u2010lipid droplet interface. J Cell Biol 198: 895-911","journal-title":"J Cell Biol"},{"key":"BFEMMM201100671_CR130","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1111\/j.1741-4520.2011.00336.x","volume":"51","author":"M Yamada","year":"2011","unstructured":"Yamada M, Wolfe D, Han G, French SW, Ross MG, Desai M (2011) Early onset of fatty liver in growth\u2010restricted rat fetuses and newborns. Congenit Anom 51: 167-173","journal-title":"Congenit Anom"},{"key":"BFEMMM201100671_CR131","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.tem.2011.02.004","volume":"22","author":"HY Yang","year":"2011","unstructured":"Yang HY, Fei WH, Du XM (2011) Seipin, adipogenesis and lipid droplets. Trends Endocrinol Metab 22: 204-210","journal-title":"Trends Endocrinol Metab"},{"key":"BFEMMM201100671_CR132","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.cmet.2008.12.013","volume":"9","author":"J Ye","year":"2009","unstructured":"Ye J, Li JZ, Liu Y, Li X, Yang T, Ma X, Li Q, Yao Z, Li P (2009) Cideb, an ER\u2010 and lipid droplet\u2010associated protein, mediates VLDL lipidation and maturation by interacting with apolipoprotein B. Cell Metab 9: 177-190","journal-title":"Cell Metab"},{"key":"BFEMMM201100671_CR133","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s13238-012-2025-6","volume":"3","author":"Y Yuan","year":"2012","unstructured":"Yuan Y, Li P, Ye J (2012) Lipid homeostasis and the formation of macrophage\u2010derived foam cells in atherosclerosis. Protein Cell 3: 173-181","journal-title":"Protein Cell"},{"key":"BFEMMM201100671_CR134","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1055\/s-0029-1243599","volume":"42","author":"W Zhai","year":"2010","unstructured":"Zhai W, Xu C, Ling Y, Liu S, Deng J, Qi Y, Londos C, Xu G (2010) Increased lipolysis in adipose tissues is associated with elevation of systemic free fatty acids and insulin resistance in perilipin null mice. Horm Metab Res 42: 247-253","journal-title":"Horm Metab Res"},{"key":"BFEMMM201100671_CR135","doi-asserted-by":"crossref","first-page":"35368","DOI":"10.1074\/jbc.M007099200","volume":"275","author":"D Zhang","year":"2000","unstructured":"Zhang D, Tang W, Yao PM, Yang C, Xie B, Jackowski S, Tabas I (2000) Macrophages deficient in CTP:phosphocholine cytidylyltransferase\u2010alpha are viable under normal culture conditions but are highly susceptible to free cholesterol\u2010induced death. Molecular genetic evidence that the induction of phosphatidylcholine biosynthesis in free cholesterol\u2010loaded macrophages is an adaptive response. J Biol Chem 275: 35368-35376","journal-title":"J Biol Chem"},{"key":"BFEMMM201100671_CR136","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.metabol.2007.11.011","volume":"57","author":"L Zhang","year":"2008","unstructured":"Zhang L, Miyaki K, Nakayama T, Muramatsu M (2008) Cell death\u2010inducing DNA fragmentation factor alpha\u2010like effector A (CIDEA) gene V115F (G\u2192T) polymorphism is associated with phenotypes of metabolic syndrome in Japanese men. Metabolism 57: 502-505","journal-title":"Metabolism"},{"key":"BFEMMM201100671_CR137","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.diabres.2010.10.016","volume":"91","author":"L Zhang","year":"2011","unstructured":"Zhang L, Dai Y, Bian L, Wang W, Muramatsu M, Hua Q (2011) Association of the cell death\u2010inducing DNA fragmentation factor alpha\u2010like effector A (CIDEA) gene V115F (G\/T) polymorphism with phenotypes of metabolic syndrome in a Chinese population. Diabetes Res Clin Pract 91: 233-238","journal-title":"Diabetes Res Clin Pract"},{"key":"BFEMMM201100671_CR138","doi-asserted-by":"crossref","first-page":"2983","DOI":"10.1172\/JCI30485","volume":"117","author":"B Zhao","year":"2007","unstructured":"Zhao B, Song JM, Chow WN, Clair RWS, Rudel LL, Ghosh S (2007) Macrophage\u2010specific transgenic expression of cholesteryl ester hydrolase significantly reduces atherosclerosis and lesion necrosis in Ldlr(\u2212)\/(\u2212) mice. J Clin Invest 117: 2983-2992","journal-title":"J Clin Invest"}],"container-title":["EMBO Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1002\/emmm.201100671.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/emmm.201100671","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1002\/emmm.201100671\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.embopress.org\/doi\/pdf\/10.1002\/emmm.201100671","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1002\/emmm.201100671.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T06:05:41Z","timestamp":1779084341000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1002\/emmm.201100671"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6,6]]},"references-count":138,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2013,7,1]]}},"alternative-id":["BFEMMM201100671"],"URL":"https:\/\/doi.org\/10.1002\/emmm.201100671","relation":{},"ISSN":["1757-4676","1757-4684"],"issn-type":[{"value":"1757-4676","type":"print"},{"value":"1757-4684","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,6,6]]},"assertion":[{"value":"21 January 2013","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 April 2013","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 May 2013","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 June 2013","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"EMMM201100671"}}