{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:48:24Z","timestamp":1792788504565,"version":"4.5.0"},"reference-count":64,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2012,3,2]],"date-time":"2012-03-02T00:00:00Z","timestamp":1330646400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2012,3,2]],"date-time":"2012-03-02T00:00:00Z","timestamp":1330646400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"crossref","award":["3100A0\u2010109340"],"award-info":[{"award-number":["3100A0\u2010109340"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"crossref","award":["310030_132884\/1 to SW"],"award-info":[{"award-number":["310030_132884\/1 to SW"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["EMBO Mol Med"],"published-print":{"date-parts":[[2012,5,1]]},"DOI":"10.1002\/emmm.201200219","type":"journal-article","created":{"date-parts":[[2012,3,4]],"date-time":"2012-03-04T11:43:29Z","timestamp":1330861409000},"page":"364-379","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":177,"title":["Nrf2 links epidermal barrier function with antioxidant defense"],"prefix":"10.1038","volume":"4","author":[{"given":"Matthias","family":"Sch\u00e4fer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hany","family":"Farwanah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann\u2010Helen","family":"Willrodt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron J.","family":"Huebner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konrad","family":"Sandhoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis","family":"Roop","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Hohl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilhelm","family":"Bloch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Werner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,3,2]]},"reference":[{"key":"BFEMMM201200219_CR1","doi-asserted-by":"crossref","first-page":"3773","DOI":"10.1128\/MCB.26.10.3773-3784.2006","volume":"26","author":"U auf dem Keller","year":"2006","unstructured":"auf dem Keller U, Huber M, Beyer TA, Kumin A, Siemes C, Braun S, Bugnon P, Mitropoulos V, Johnson DA, Johnson JA, et al (2006) Nrf transcription factors in keratinocytes are essential for skin tumor prevention but not for wound healing. Mol Cell Biol 26: 3773\u20103784","journal-title":"Mol Cell Biol"},{"key":"BFEMMM201200219_CR2","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1038\/sj.emboj.7601950","volume":"27","author":"TA Beyer","year":"2008","unstructured":"Beyer TA, Xu W, Teupser D, auf dem Keller U, Bugnon P, Hildt E, Thiery J, Kan YW, Werner S (2008) Impaired liver regeneration in Nrf2 knockout mice: role of ROS\u2010mediated insulin\/IGF\u20101 resistance. EMBO J 27: 212\u2010223","journal-title":"EMBO J"},{"key":"BFEMMM201200219_CR3","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1038\/nature05904","volume":"447","author":"NA Bishop","year":"2007","unstructured":"Bishop NA, Guarente L (2007) Two neurons mediate diet\u2010restriction\u2010induced longevity in C. elegans. Nature 447: 545\u2010549","journal-title":"Nature"},{"key":"BFEMMM201200219_CR4","doi-asserted-by":"crossref","first-page":"3640","DOI":"10.1074\/jbc.M607567200","volume":"282","author":"CA Borgono","year":"2007","unstructured":"Borgono CA, Michael IP, Komatsu N, Jayakumar A, Kapadia R, Clayman GL, Sotiropoulou G, Diamandis EP (2007) A potential role for multiple tissue kallikrein serine proteases in epidermal desquamation. J Biol Chem 282: 3640\u20103652","journal-title":"J Biol Chem"},{"key":"BFEMMM201200219_CR5","doi-asserted-by":"crossref","first-page":"111","DOI":"10.7150\/ijbs.3.111","volume":"3","author":"DJ Cameron","year":"2007","unstructured":"Cameron DJ, Tong Z, Yang Z, Kaminoh J, Kamiyah S, Chen H, Zeng J, Chen Y, Luo L, Zhang K (2007) Essential role of Elovl4 in very long chain fatty acid synthesis, skin permeability barrier function, and neonatal survival. Int J Biol Sci 3: 111\u2010119","journal-title":"Int J Biol Sci"},{"key":"BFEMMM201200219_CR6","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1111\/j.0022-202X.2004.22512.x","volume":"122","author":"C Caubet","year":"2004","unstructured":"Caubet C, Jonca N, Brattsand M, Guerrin M, Bernard D, Schmidt R, Egelrud T, Simon M, Serre G (2004) Degradation of corneodesmosome proteins by two serine proteases of the kallikrein family, SCTE\/KLK5\/hK5 and SCCE\/KLK7\/hK7. J Invest Dermatol 122: 1235\u20101244","journal-title":"J Invest Dermatol"},{"key":"BFEMMM201200219_CR7","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.tox.2007.10.029","volume":"246","author":"IM Copple","year":"2008","unstructured":"Copple IM, Goldring CE, Kitteringham NR, Park BK (2008) The Nrf2\u2010Keap1 defence pathway: role in protection against drug\u2010induced toxicity. Toxicology 246: 24\u201033","journal-title":"Toxicology"},{"key":"BFEMMM201200219_CR8","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1016\/j.freeradbiomed.2008.09.001","volume":"45","author":"HE de Vries","year":"2008","unstructured":"de Vries HE, Witte M, Hondius D, Rozemuller AJ, Drukarch B, Hoozemans J, van Horssen J (2008) Nrf2\u2010induced antioxidant protection: A promising target to counteract ROS\u2010mediated damage in neurodegenerative disease? Free Radic Biol Med 45: 1375\u20101383","journal-title":"Free Radic Biol Med"},{"key":"BFEMMM201200219_CR9","doi-asserted-by":"crossref","first-page":"e1000067","DOI":"10.1371\/journal.pbio.1000067","volume":"7","author":"S Demehri","year":"2009","unstructured":"Demehri S, Morimoto M, Holtzman MJ, Kopan R (2009) Skin\u2010derived TSLP triggers progression from epidermal\u2010barrier defects to asthma. PLoS Biol 7: e1000067","journal-title":"PLoS Biol"},{"key":"BFEMMM201200219_CR10","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/nature10189","volume":"475","author":"GM Denicola","year":"2011","unstructured":"Denicola GM, Karreth FA, Humpton TJ, Gopinathan A, Wei C, Frese K, Mangal D, Yu KH, Yeo CJ, Calhoun ES, et al (2011) Oncogene\u2010induced Nrf2 transcription promotes ROS detoxification and tumorigenesis. Nature 475: 106\u2010109","journal-title":"Nature"},{"key":"BFEMMM201200219_CR11","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.canlet.2005.09.012","volume":"240","author":"AT Dinkova\u2010Kostova","year":"2006","unstructured":"Dinkova\u2010Kostova AT, Jenkins SN, Fahey JW, Ye L, Wehage SL, Liby KT, Stephenson KK, Wade KL, Talalay P (2006) Protection against UV\u2010light\u2010induced skin carcinogenesis in SKH\u20101 high\u2010risk mice by sulforaphane\u2010containing broccoli sprout extracts. Cancer Lett 240: 243\u2010252","journal-title":"Cancer Lett"},{"key":"BFEMMM201200219_CR12","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1172\/JCI27186","volume":"116","author":"AR Djalilian","year":"2006","unstructured":"Djalilian AR, McGaughey D, Patel S, Seo EY, Yang C, Cheng J, Tomic M, Sinha S, Ishida\u2010Yamamoto A, Segre JA (2006) Connexin 26 regulates epidermal barrier and wound remodeling and promotes psoriasiform response. J Clin Invest 116: 1243\u20101253","journal-title":"J Clin Invest"},{"key":"BFEMMM201200219_CR13","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1128\/IAI.73.3.1271-1274.2005","volume":"73","author":"S Doumas","year":"2005","unstructured":"Doumas S, Kolokotronis A, Stefanopoulos P (2005) Anti\u2010inflammatory and antimicrobial roles of secretory leukocyte protease inhibitor. Infect Immun 73: 1271\u20101274","journal-title":"Infect Immun"},{"key":"BFEMMM201200219_CR14","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1093\/nar\/30.1.207","volume":"30","author":"R Edgar","year":"2002","unstructured":"Edgar R, Domrachev M, Lash AE (2002) Gene Expression Omnibus: NCBI gene expression and hybridization array data repository. Nucleic Acids Res 30: 207\u2010210","journal-title":"Nucleic Acids Res"},{"key":"BFEMMM201200219_CR15","doi-asserted-by":"crossref","first-page":"245","DOI":"10.5021\/ad.2010.22.3.245","volume":"22","author":"PM Elias","year":"2010","unstructured":"Elias PM (2010) Therapeutic implications of a barrier\u2010based pathogenesis of atopic dermatitis. Ann Dermatol 22: 245\u2010254","journal-title":"Ann Dermatol"},{"key":"BFEMMM201200219_CR16","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1194\/jlr.R800002-JLR200","volume":"49","author":"PM Elias","year":"2008","unstructured":"Elias PM, Williams ML, Holleran WM, Jiang YJ, Schmuth M (2008) Pathogenesis of permeability barrier abnormalities in the ichthyoses: inherited disorders of lipid metabolism. J Lipid Res 49: 697\u2010714","journal-title":"J Lipid Res"},{"key":"BFEMMM201200219_CR17","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.jchromb.2007.02.030","volume":"852","author":"H Farwanah","year":"2007","unstructured":"Farwanah H, Pierstorff B, Schmelzer CE, Raith K, Neubert RH, Kolter T, Sandhoff K (2007) Separation and mass spectrometric characterization of covalently bound skin ceramides using LC\/APCI\u2010MS and Nano\u2010ESI\u2010MS\/MS. J Chromatogr B Analyt Technol Biomed Life Sci 852: 562\u2010570","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"key":"BFEMMM201200219_CR18","doi-asserted-by":"crossref","first-page":"21886","DOI":"10.1074\/jbc.271.36.21886","volume":"271","author":"CW Franzke","year":"1996","unstructured":"Franzke CW, Baici A, Bartels J, Christophers E, Wiedow O (1996) Antileukoprotease inhibits stratum corneum chymotryptic enzyme. Evidence for a regulative function in desquamation. J Biol Chem 271: 21886\u201021890","journal-title":"J Biol Chem"},{"key":"BFEMMM201200219_CR19","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1083\/jcb.200110122","volume":"156","author":"M Furuse","year":"2002","unstructured":"Furuse M, Hata M, Furuse K, Yoshida Y, Haratake A, Sugitani Y, Noda T, Kubo A, Tsukita S (2002) Claudin\u2010based tight junctions are crucial for the mammalian epidermal barrier: a lesson from claudin\u20101\u2010deficient mice. J Cell Biol 156: 1099\u20101111","journal-title":"J Cell Biol"},{"key":"BFEMMM201200219_CR20","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.plipres.2009.12.002","volume":"49","author":"H Guillou","year":"2010","unstructured":"Guillou H, Zadravec D, Martin PG, Jacobsson A (2010) The key roles of elongases and desaturases in mammalian fatty acid metabolism: insights from transgenic mice. Prog Lipid Res 49: 186\u2010199","journal-title":"Prog Lipid Res"},{"key":"BFEMMM201200219_CR21","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1053\/j.gastro.2004.07.022","volume":"127","author":"S Hadj\u2010Rabia","year":"2004","unstructured":"Hadj\u2010Rabia S, Baala L, Vabres P, Hamel\u2010Teillac D, Jacquemin E, Fabre M, Lyonnet S, De Prost Y, Munnich A, Hadchouel M, et al (2004) Claudin\u20101 gene mutations in neonatal sclerosing cholangitis associated with ichthyosis: a tight junction disease. Gastroenterology 127: 1386\u20101390","journal-title":"Gastroenterology"},{"key":"BFEMMM201200219_CR22","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.tibs.2008.12.008","volume":"34","author":"JD Hayes","year":"2009","unstructured":"Hayes JD, McMahon M (2009) NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer. Trends Biochem Sci 34: 176\u2010188","journal-title":"Trends Biochem Sci"},{"key":"BFEMMM201200219_CR23","first-page":"121.001\u2010070","volume-title":"Harper's Textbook of Pediatric Dermatology","author":"D Hohl","year":"2011","unstructured":"Hohl D, Williams M (2011) Mendelian disorders of cornification (MEDOC): The ichthyoses. In: Harper's Textbook of Pediatric Dermatology, Irvine A, H\u00f6ger P, Yan A (Eds), Oxford, Blackwell Publishing Ltd.: pp 121.001\u2010070"},{"key":"BFEMMM201200219_CR24","doi-asserted-by":"crossref","first-page":"3423","DOI":"10.1158\/1078-0432.CCR-08-2822","volume":"15","author":"S Homma","year":"2009","unstructured":"Homma S, Ishii Y, Morishima Y, Yamadori T, Matsuno Y, Haraguchi N, Kikuchi N, Satoh H, Sakamoto T, Hizawa N, et al (2009) Nrf2 enhances cell proliferation and resistance to anticancer drugs in human lung cancer. Clin Cancer Res 15: 3423\u20103432","journal-title":"Clin Cancer Res"},{"key":"BFEMMM201200219_CR25","doi-asserted-by":"crossref","first-page":"6968","DOI":"10.4049\/jimmunol.175.10.6968","volume":"175","author":"Y Ishii","year":"2005","unstructured":"Ishii Y, Itoh K, Morishima Y, Kimura T, Kiwamoto T, Iizuka T, Hegab AE, Hosoya T, Nomura A, Sakamoto T, et al (2005) Transcription factor Nrf2 plays a pivotal role in protection against elastase\u2010induced pulmonary inflammation and emphysema. J Immunol 175: 6968\u20106975","journal-title":"J Immunol"},{"key":"BFEMMM201200219_CR26","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1172\/JCI5307","volume":"104","author":"JM Jensen","year":"1999","unstructured":"Jensen JM, Schutze S, Forl M, Kronke M, Proksch E (1999) Roles for tumor necrosis factor receptor p55 and sphingomyelinase in repairing the cutaneous permeability barrier. J Clin Invest 104: 1761\u20101770","journal-title":"J Clin Invest"},{"key":"BFEMMM201200219_CR27","doi-asserted-by":"crossref","first-page":"14460","DOI":"10.1073\/pnas.0706486104","volume":"104","author":"ML Kerns","year":"2007","unstructured":"Kerns ML, DePianto D, Dinkova\u2010Kostova AT, Talalay P, Coulombe PA, (2007) Reprogramming of keratin biosynthesis by sulforaphane restores skin integrity in epidermolysis bullosa simplex. Proc Natl Acad Sci USA 104: 14460\u201014465","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMMM201200219_CR28","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1002\/path.2653","volume":"220","author":"YR Kim","year":"2010","unstructured":"Kim YR, Oh JE, Kim MS, Kang MR, Park SW, Han JY, Eom HS, Yoo NJ, Lee SH (2010) Oncogenic NRF2 mutations in squamous cell carcinomas of oesophagus and skin. J Pathol 220: 446\u2010451","journal-title":"J Pathol"},{"key":"BFEMMM201200219_CR29","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1083\/jcb.151.2.389","volume":"151","author":"PJ Koch","year":"2000","unstructured":"Koch PJ, de Viragh PA, Scharer E, Bundman D, Longley MA, Bickenbach J, Kawachi Y, Suga Y, Zhou Z, Huber M, et al (2000) Lessons from loricrin\u2010deficient mice: compensatory mechanisms maintaining skin barrier function in the absence of a major cornified envelope protein. J Cell Biol 151: 389\u2010400","journal-title":"J Cell Biol"},{"key":"BFEMMM201200219_CR30","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1007\/s11095-010-0096-8","volume":"27","author":"JK Kundu","year":"2010","unstructured":"Kundu JK, Surh YJ (2010) Nrf2\u2010Keap1 signaling as a potential target for chemoprevention of inflammation\u2010associated carcinogenesis. Pharm Res 27: 999\u20101013","journal-title":"Pharm Res"},{"key":"BFEMMM201200219_CR31","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.taap.2009.08.028","volume":"244","author":"MK Kwak","year":"2010","unstructured":"Kwak MK, Kensler TW (2010) Targeting NRF2 signaling for cancer chemoprevention. Toxicol Appl Pharmacol 244: 66\u201076","journal-title":"Toxicol Appl Pharmacol"},{"key":"BFEMMM201200219_CR32","doi-asserted-by":"crossref","first-page":"35184","DOI":"10.1074\/jbc.M301666200","volume":"278","author":"PA Ladd","year":"2003","unstructured":"Ladd PA, Du L, Capdevila JH, Mernaugh R, Keeney DS (2003) Epoxyeicosatrienoic acids activate transglutaminases in situ and induce cornification of epidermal keratinocytes. J Biol Chem 278: 35184\u201035192","journal-title":"J Biol Chem"},{"key":"BFEMMM201200219_CR33","doi-asserted-by":"crossref","first-page":"120","DOI":"10.7150\/ijbs.3.120","volume":"3","author":"W Li","year":"2007","unstructured":"Li W, Sandhoff R, Kono M, Zerfas P, Hoffmann V, Ding BC, Proia RL, Deng CX (2007) Depletion of ceramides with very long chain fatty acids causes defective skin permeability barrier function, and neonatal lethality in ELOVL4 deficient mice. Int J Biol Sci 3: 120\u2010128","journal-title":"Int J Biol Sci"},{"key":"BFEMMM201200219_CR34","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nrc2129","volume":"7","author":"KT Liby","year":"2007","unstructured":"Liby KT, Yore MM, Sporn MB (2007) Triterpenoids and rexinoids as multifunctional agents for the prevention and treatment of cancer. Nat Rev Cancer 7: 357\u2010369","journal-title":"Nat Rev Cancer"},{"key":"BFEMMM201200219_CR35","doi-asserted-by":"crossref","first-page":"479","DOI":"10.3109\/10715761003667554","volume":"44","author":"GY Liou","year":"2010","unstructured":"Liou GY, Storz P (2010) Reactive oxygen species in cancer. Free Radic Res 44: 479\u2010496","journal-title":"Free Radic Res"},{"key":"BFEMMM201200219_CR36","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1038\/sj.jid.5701026","volume":"128","author":"MQ Man","year":"2008","unstructured":"Man MQ, Barish GD, Schmuth M, Crumrine D, Barak Y, Chang S, Jiang Y, Evans RM, Elias PM, Feingold KR (2008) Deficiency of PPARbeta\/delta in the epidermis results in defective cutaneous permeability barrier homeostasis and increased inflammation. J Invest Dermatol 128: 370\u2010377","journal-title":"J Invest Dermatol"},{"key":"BFEMMM201200219_CR37","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1038\/jid.2011.90","volume":"131","author":"I Marenholz","year":"2011","unstructured":"Marenholz I, Rivera VA, Esparza\u2010Gordillo J, Bauerfeind A, Lee\u2010Kirsch MA, Ciechanowicz A, Kurek M, Piskackova T, Macek M, Lee YA (2011) Association screening in the epidermal differentiation complex (EDC) identifies an SPRR3 repeat number variant as a risk factor for eczema. J Invest Dermatol 131: 1644\u20101649","journal-title":"J Invest Dermatol"},{"key":"BFEMMM201200219_CR38","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1007\/s00335-002-2205-4","volume":"14","author":"S Patel","year":"2003","unstructured":"Patel S, Kartasova T, Segre JA (2003) Mouse Sprr locus: a tandem array of coordinately regulated genes. Mamm Genome 14: 140\u2010148","journal-title":"Mamm Genome"},{"key":"BFEMMM201200219_CR39","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.coph.2009.08.005","volume":"9","author":"P Perez\u2010Matute","year":"2009","unstructured":"Perez\u2010Matute P, Zulet MA, Martinez JA (2009) Reactive species and diabetes: counteracting oxidative stress to improve health. Curr Opin Pharmacol 9: 771\u2010779","journal-title":"Curr Opin Pharmacol"},{"key":"BFEMMM201200219_CR40","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1111\/j.0022-202X.2004.23226.x","volume":"123","author":"RB Presland","year":"2004","unstructured":"Presland RB, Coulombe PA, Eckert RL, Mao\u2010Qiang M, Feingold KR, Elias PM (2004) Barrier function in transgenic mice overexpressing K16, involucrin, and filaggrin in the suprabasal epidermis. J Invest Dermatol 123: 603\u2010606","journal-title":"J Invest Dermatol"},{"key":"BFEMMM201200219_CR41","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1111\/j.1600-0625.2008.00786.x","volume":"17","author":"E Proksch","year":"2008","unstructured":"Proksch E, Brandner JM, Jensen JM (2008) The skin: an indispensable barrier. Exp Dermatol 17: 1063\u20101072","journal-title":"Exp Dermatol"},{"key":"BFEMMM201200219_CR42","doi-asserted-by":"crossref","first-page":"3410","DOI":"10.1073\/pnas.051618798","volume":"98","author":"M Ramos\u2010Gomez","year":"2001","unstructured":"Ramos\u2010Gomez M, Kwak MK, Dolan PM, Itoh K, Yamamoto M, Talalay P, Kensler TW (2001) Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor\u2010deficient mice. Proc Natl Acad Sci USA 98: 3410\u20103415","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMMM201200219_CR43","doi-asserted-by":"crossref","first-page":"5821","DOI":"10.1038\/onc.2008.188","volume":"27","author":"NM Reddy","year":"2008","unstructured":"Reddy NM, Kleeberger SR, Bream JH, Fallon PG, Kensler TW, Yamamoto M, Reddy SP (2008) Genetic disruption of the Nrf2 compromises cell\u2010cycle progression by impairing GSH\u2010induced redox signaling. Oncogene 27: 5821\u20105832","journal-title":"Oncogene"},{"key":"BFEMMM201200219_CR44","doi-asserted-by":"crossref","first-page":"11632","DOI":"10.1016\/S0021-9258(18)99004-6","volume":"266","author":"TH Rushmore","year":"1991","unstructured":"Rushmore TH, Morton MR, Pickett CB (1991) The antioxidant responsive element. Activation by oxidative stress and identification of the DNA consensus sequence required for functional activity. J Biol Chem 266: 11632\u201011639","journal-title":"J Biol Chem"},{"key":"BFEMMM201200219_CR45","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1242\/jcs.033969","volume":"122","author":"A Sandilands","year":"2009","unstructured":"Sandilands A, Sutherland C, Irvine AD, McLean WH (2009) Filaggrin in the frontline: role in skin barrier function and disease. J Cell Sci 122: 1285\u20101294","journal-title":"J Cell Sci"},{"key":"BFEMMM201200219_CR46","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1006\/excr.1998.4175","volume":"244","author":"JA Sawicki","year":"1998","unstructured":"Sawicki JA, Morris RJ, Monks B, Sakai K, Miyazaki J (1998) A composite CMV\u2010IE enhancer\/beta\u2010actin promoter is ubiquitously expressed in mouse cutaneous epithelium. Exp Cell Res 244: 367\u2010369","journal-title":"Exp Cell Res"},{"key":"BFEMMM201200219_CR47","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1101\/gad.568810","volume":"24","author":"M Sch\u00e4fer","year":"2010","unstructured":"Sch\u00e4fer M, D\u00fctsch S, auf dem Keller U, Navid F, Schwarz A, Johnson DA, Johnson JA, Werner S (2010) Nrf2 establishes a glutathione\u2010mediated gradient of UVB cytoprotection in the epidermis. Genes Dev 24: 1045\u20101058","journal-title":"Genes Dev"},{"key":"BFEMMM201200219_CR48","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.jaci.2009.06.046","volume":"124","author":"TC Scharschmidt","year":"2009","unstructured":"Scharschmidt TC, Man MQ, Hatano Y, Crumrine D, Gunathilake R, Sundberg JP, Silva KA, Mauro TM, Hupe M, Cho S, et al (2009) Filaggrin deficiency confers a paracellular barrier abnormality that reduces inflammatory thresholds to irritants and haptens. J Allergy Clin Immunol 124: 496\u2010506 e491\u2013496","journal-title":"J Allergy Clin Immunol"},{"key":"BFEMMM201200219_CR49","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1083\/jcb.200706187","volume":"179","author":"LM Sevilla","year":"2007","unstructured":"Sevilla LM, Nachat R, Groot KR, Klement JF, Uitto J, Djian P, Maatta A, Watt FM (2007) Mice deficient in involucrin, envoplakin, and periplakin have a defective epidermal barrier. J Cell Biol 179: 1599\u20101612","journal-title":"J Cell Biol"},{"key":"BFEMMM201200219_CR50","doi-asserted-by":"crossref","first-page":"re3","DOI":"10.1126\/scisignal.3112re3","volume":"3","author":"GP Sykiotis","year":"2010","unstructured":"Sykiotis GP, Bohmann D (2010) Stress\u2010activated cap'n'collar transcription factors in aging and human disease. Sci Signal 3: re3","journal-title":"Sci Signal"},{"key":"BFEMMM201200219_CR51","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/S0092-8674(00)00178-1","volume":"103","author":"A Szabowski","year":"2000","unstructured":"Szabowski A, Maas\u2010Szabowski N, Andrecht S, Kolbus A, Schorpp\u2010Kistner M, Fusenig NE, Angel P (2000) c\u2010Jun and JunB antagonistically control cytokine\u2010regulated mesenchymal\u2013epidermal interaction in skin. Cell 103: 745\u2010755","journal-title":"Cell"},{"key":"BFEMMM201200219_CR52","doi-asserted-by":"crossref","first-page":"3016","DOI":"10.1128\/MCB.01591-09","volume":"30","author":"K Taguchi","year":"2010","unstructured":"Taguchi K, Maher JM, Suzuki T, Kawatani Y, Motohashi H, Yamamoto M (2010) Genetic analysis of cytoprotective functions supported by graded expression of Keap1. Mol Cell Biol 30: 3016\u20103026","journal-title":"Mol Cell Biol"},{"key":"BFEMMM201200219_CR53","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1093\/hmg\/ddl480","volume":"16","author":"V Vasireddy","year":"2007","unstructured":"Vasireddy V, Uchida Y, Salem N, Jr., Kim SY, Mandal MN, Reddy GB, Bodepudi R, Alderson NL, Brown JC, Hama H, et al (2007) Loss of functional ELOVL4 depletes very long\u2010chain fatty acids (>or =C28) and the unique omega\u2010O\u2010acylceramides in skin leading to neonatal death. Hum Mol Genet 16: 471\u2010482","journal-title":"Hum Mol Genet"},{"key":"BFEMMM201200219_CR54","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1038\/jid.2010.433","volume":"131","author":"WP Vermeij","year":"2011","unstructured":"Vermeij WP, Alia A, Backendorf C (2011) ROS quenching potential of the epidermal cornified cell envelope. J Invest Dermatol 131: 1435\u20101441","journal-title":"J Invest Dermatol"},{"key":"BFEMMM201200219_CR55","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1038\/nrrheum.2010.157","volume":"6","author":"EF Wagner","year":"2010","unstructured":"Wagner EF, Schonthaler HB, Guinea\u2010Viniegra J, Tschachler E (2010) Psoriasis: What we have learned from mouse models. Nat Rev Rheumatol 6: 704\u2010714","journal-title":"Nat Rev Rheumatol"},{"key":"BFEMMM201200219_CR56","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/ng1248","volume":"35","author":"N Wakabayashi","year":"2003","unstructured":"Wakabayashi N, Itoh K, Wakabayashi J, Motohashi H, Noda S, Takahashi S, Imakado S, Kotsuji T, Otsuka F, Roop DR, et al (2003) Keap1\u2010null mutation leads to postnatal lethality due to constitutive Nrf2 activation. Nat Genet 35: 238\u2010245","journal-title":"Nat Genet"},{"key":"BFEMMM201200219_CR57","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1002\/path.2200","volume":"212","author":"RE Watson","year":"2007","unstructured":"Watson RE, Poddar R, Walker JM, McGuill I, Hoare LM, Griffiths CE, O'Neill CA (2007) Altered claudin expression is a feature of chronic plaque psoriasis. J Pathol 212: 450\u2010458","journal-title":"J Pathol"},{"key":"BFEMMM201200219_CR58","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1038\/sj.jid.5700786","volume":"127","author":"S Werner","year":"2007","unstructured":"Werner S, Krieg T, Smola H (2007) Keratinocyte\u2013fibroblast interactions in wound healing. J Invest Dermatol 127: 998\u20101008","journal-title":"J Invest Dermatol"},{"key":"BFEMMM201200219_CR59","doi-asserted-by":"crossref","first-page":"5621","DOI":"10.1074\/jbc.M310529200","volume":"279","author":"R Westerberg","year":"2004","unstructured":"Westerberg R, Tvrdik P, Unden AB, Mansson JE, Norlen L, Jakobsson A, Holleran WH, Elias PM, Asadi A, Flodby P, et al (2004) Role for ELOVL3 and fatty acid chain length in development of hair and skin function. J Biol Chem 279: 5621\u20105629","journal-title":"J Biol Chem"},{"key":"BFEMMM201200219_CR60","doi-asserted-by":"crossref","first-page":"440","DOI":"10.4161\/viru.1.5.12983","volume":"1","author":"J Wiesner","year":"2010","unstructured":"Wiesner J, Vilcinskas A (2010) Antimicrobial peptides: the ancient arm of the human immune system. Virulence 1: 440\u2010464","journal-title":"Virulence"},{"key":"BFEMMM201200219_CR61","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1172\/JCI115884","volume":"90","author":"LC Wood","year":"1992","unstructured":"Wood LC, Jackson SM, Elias PM, Grunfeld C, Feingold KR (1992) Cutaneous barrier perturbation stimulates cytokine production in the epidermis of mice. J Clin Invest 90: 482\u2010487","journal-title":"J Clin Invest"},{"key":"BFEMMM201200219_CR62","doi-asserted-by":"crossref","first-page":"8293","DOI":"10.1158\/0008-5472.CAN-06-0300","volume":"66","author":"C Xu","year":"2006","unstructured":"Xu C, Huang MT, Shen G, Yuan X, Lin W, Khor TO, Conney AH, Kong AN (2006) Inhibition of 7,12\u2010dimethylbenz(a)anthracene\u2010induced skin tumorigenesis in C57BL\/6 mice by sulforaphane is mediated by nuclear factor E2\u2010related factor 2. Cancer Res 66: 8293\u20108296","journal-title":"Cancer Res"},{"key":"BFEMMM201200219_CR63","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1158\/1940-6207.CAPR-08-0192","volume":"2","author":"A Yanaka","year":"2009","unstructured":"Yanaka A, Fahey JW, Fukumoto A, Nakayama M, Inoue S, Zhang S, Tauchi M, Suzuki H, Hyodo I, Yamamoto M (2009) Dietary sulforaphane\u2010rich broccoli sprouts reduce colonization and attenuate gastritis in Helicobacter pylori\u2010infected mice and humans. Cancer Prev Res (Phila Pa) 2: 353\u2010360","journal-title":"Cancer Prev Res (Phila Pa)"},{"key":"BFEMMM201200219_CR64","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1083\/jcb.200910126","volume":"188","author":"J Yang","year":"2010","unstructured":"Yang J, Meyer M, Muller AK, Bohm F, Grose R, Dauwalder T, Verrey F, Kopf M, Partanen J, Bloch W, et al (2010) Fibroblast growth factor receptors 1 and 2 in keratinocytes control the epidermal barrier and cutaneous homeostasis. J Cell Biol 188: 935\u2010952","journal-title":"J Cell Biol"}],"container-title":["EMBO Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1002\/emmm.201200219.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/emmm.201200219","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1002\/emmm.201200219\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.embopress.org\/doi\/pdf\/10.1002\/emmm.201200219","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1002\/emmm.201200219.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T06:01:27Z","timestamp":1779084087000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1002\/emmm.201200219"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3,2]]},"references-count":64,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012,5,1]]}},"alternative-id":["BFEMMM201200219"],"URL":"https:\/\/doi.org\/10.1002\/emmm.201200219","relation":{},"ISSN":["1757-4676","1757-4684"],"issn-type":[{"value":"1757-4676","type":"print"},{"value":"1757-4684","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,3,2]]},"assertion":[{"value":"1 October 2011","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 January 2012","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 January 2012","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 March 2012","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}