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Its pathogenesis is complex, involving both parasite\u2010 and immune\u2010mediated events. CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells play an effector role in murine experimental cerebral malaria (ECM) induced by\n                    <jats:italic>Plasmodium berghei<\/jats:italic>\n                    ANKA (PbA) infection. We have identified a highly immunogenic CD8 epitope in glideosome\u2010associated protein 50 that is conserved across rodent malaria species. Epitope\u2010specific CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells are induced during PbA infection, migrating to the brain just before neurological signs manifest. They are functional, cytotoxic and can damage the blood\u2013brain barrier\n                    <jats:italic>in vivo<\/jats:italic>\n                    . Such CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells are also found in the brain during infection with parasite strains\/species that do not induce neuropathology. We demonstrate here that PbA infection causes brain microvessels to cross\u2010present parasite antigen, while non\u2010ECM\u2010causing parasites do not. Further, treatment with fast\u2010acting anti\u2010malarial drugs before the onset of ECM reduces parasite load and thus antigen presentation in the brain, preventing ECM death. Thus our data suggest that combined therapies targeting both the parasite and host antigen\u2010presenting cells may improve the outcome of CM patients.\n                  <\/jats:p>","DOI":"10.1002\/emmm.201202273","type":"journal-article","created":{"date-parts":[[2013,5,16]],"date-time":"2013-05-16T06:41:12Z","timestamp":1368686472000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":148,"title":["Brain microvessel cross\u2010presentation is a hallmark of experimental cerebral malaria"],"prefix":"10.1038","volume":"5","author":[{"given":"Shanshan W.","family":"Howland","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chek Meng","family":"Poh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sin Yee","family":"Gun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Claser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benoit","family":"Malleret","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nilabh","family":"Shastri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florent","family":"Ginhoux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gijsbert M.","family":"Grotenbreg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"R\u00e9nia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,5,16]]},"reference":[{"key":"BFEMMM201202273_CR1","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1002\/1521-4141(200006)30:6<1646::AID-IMMU1646>3.0.CO;2-0","volume":"30","author":"V Amani","year":"2000","unstructured":"Amani V, Vigario AM, Belnoue E, Marussig M, Fonseca L, Mazier D, Renia L (2000) Involvement of IFN\u2010gamma receptor\u2010medicated signaling in pathology and anti\u2010malarial immunity induced by Plasmodium berghei infection. 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