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However, the role of IL\u201027 in the pathogenesis of secondary pneumococcal pneumonia after influenza is unknown. We now report that influenza infection induced pulmonary IL\u201027 production in a type I IFN\u2010\u03b1\/\u03b2 receptor (IFNAR) signalling\u2010dependent manner, which sensitized mice to secondary pneumococcal infection downstream of IFNAR pathway. Mice deficient in IL\u201027 receptor were resistant to secondary pneumococcal infection and generated more IL\u201017A\u2010producing \u03b3\u03b4 T cells but not \u03b1\u03b2 T cells, thereby leading to enhanced neutrophil response during the early phase of host defence. IL\u201027 treatment could suppress the development of IL\u201017A\u2010producing \u03b3\u03b4 T cells activated by\n                    <jats:italic>Streptococcus pneumoniae<\/jats:italic>\n                    and dendritic cells. This suppressive activity of IL\u201027 on \u03b3\u03b4 T cells was dependent on transcription factor STAT1. Finally, neutralization of IL\u201027 or administration of IL\u201017A restored the role of \u03b3\u03b4 T cells in combating secondary pneumococcal infection. Our study defines what we believe to be a novel role of IL\u201027 in impairing host innate immunity against pneumococcal infection.\n                  <\/jats:p>","DOI":"10.1002\/emmm.201302890","type":"journal-article","created":{"date-parts":[[2013,10,29]],"date-time":"2013-10-29T08:18:57Z","timestamp":1383034737000},"page":"120-140","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":85,"title":["Activation of IL\u201027 signalling promotes development of postinfluenza pneumococcal pneumonia"],"prefix":"10.1038","volume":"6","author":[{"given":"Ju","family":"Cao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongsheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zixin","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dageng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dairong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huajian","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xaiofei","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shihui","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuemei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guosheng","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yubing","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yibing","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,10,29]]},"reference":[{"key":"BFEMMM201302890_CR1","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1038\/ni.2406","volume":"13","author":"J Banchereau","year":"2012","unstructured":"Banchereau J, Pascual V, O'Garra A (2012) From IL\u20102 to IL\u201037: the expanding spectrum of anti\u2010inflammatory cytokines. 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