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However, inflammatory stimuli can trigger IFNAR1 ubiquitination and downregulation thereby attenuating IFN effects\n                    <jats:italic>in vitro<\/jats:italic>\n                    . The significance of this paradoxical regulation is unknown. Presented here results demonstrate that inability to stimulate IFNAR1 ubiquitination in the\n                    <jats:italic>Ifnar1<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>SA<\/jats:italic>\n                    <\/jats:sup>\n                    knock\u2010in mice renders them highly susceptible to numerous inflammatory syndromes including acute and chronic pancreatitis, and autoimmune and toxic hepatitis.\n                    <jats:italic>Ifnar1<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>SA<\/jats:italic>\n                    <\/jats:sup>\n                    mice (or their bone marrow\u2010receiving wild type animals) display persistent immune infiltration of inflamed tissues, extensive damage and gravely inadequate tissue regeneration. Pharmacologic stimulation of IFNAR1 ubiquitination is protective against from toxic hepatitis and fulminant generalized inflammation in wild type but not\n                    <jats:italic>Ifnar1<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>SA<\/jats:italic>\n                    <\/jats:sup>\n                    mice. These results suggest that endogenous mechanisms that trigger IFNAR1 ubiquitination for limiting the inflammation\u2010induced tissue damage can be purposely mimicked for therapeutic benefits.\n                  <\/jats:p>","DOI":"10.1002\/emmm.201303236","type":"journal-article","created":{"date-parts":[[2014,2,3]],"date-time":"2014-02-03T14:07:29Z","timestamp":1391436449000},"page":"384-397","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["Triggering ubiquitination of IFNAR1 protects tissues from inflammatory injury"],"prefix":"10.1038","volume":"6","author":[{"given":"Sabyasachi","family":"Bhattacharya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanstantsin V","family":"Katlinski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximilian","family":"Reichert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigetsugu","family":"Takano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Brice","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiujing","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J","family":"Carbone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuliya V","family":"Katlinskaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N Adrian","family":"Leu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly A","family":"McCorkell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satish","family":"Srinivasan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Girondo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hallgeir","family":"Rui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J","family":"May","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narayan G","family":"Avadhani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anil K","family":"Rustgi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serge Y","family":"Fuchs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,1,31]]},"reference":[{"key":"BFEMMM201303236_CR1","doi-asserted-by":"crossref","first-page":"4731","DOI":"10.1182\/blood.V87.11.4731.bloodjournal87114731","volume":"87","author":"MJ Aman","year":"1996","unstructured":"Aman MJ, Tretter T, Eisenbeis I, Bug G, Decker T, Aulitzky WE, Tilg H, Huber C, Peschel C (1996) Interferon\u2010alpha stimulates production of interleukin\u201010 in activated CD4+ T cells and monocytes. 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