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These sensor pathways monitor cellular energy metabolism, especially mitochondrial ATP production and NAD\n                    <jats:sup>+<\/jats:sup>\n                    \/NADH ratio, as major signals for nutritional state. We hypothesized that these signals would be modified by mitochondrial respiratory chain disease, because of inefficient NADH utilization and ATP production. Oral administration of nicotinamide riboside (NR), a vitamin B3 and NAD\n                    <jats:sup>+<\/jats:sup>\n                    precursor, was previously shown to boost NAD\n                    <jats:sup>+<\/jats:sup>\n                    levels in mice and to induce mitochondrial biogenesis. Here, we treated mitochondrial myopathy mice with NR. This vitamin effectively delayed early\u2010 and late\u2010stage disease progression, by robustly inducing mitochondrial biogenesis in skeletal muscle and brown adipose tissue, preventing mitochondrial ultrastructure abnormalities and mtDNA deletion formation. NR further stimulated mitochondrial unfolded protein response, suggesting its protective role in mitochondrial disease. These results indicate that NR and strategies boosting NAD\n                    <jats:sup>+<\/jats:sup>\n                    levels are a promising treatment strategy for mitochondrial myopathy.\n                  <\/jats:p>","DOI":"10.1002\/emmm.201403943","type":"journal-article","created":{"date-parts":[[2014,4,8]],"date-time":"2014-04-08T12:06:29Z","timestamp":1396958789000},"page":"721-731","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":382,"title":["Effective treatment of mitochondrial myopathy by nicotinamide riboside, a vitamin B3"],"prefix":"10.1038","volume":"6","author":[{"given":"Nahid A","family":"Khan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mari","family":"Auranen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilse","family":"Paetau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eija","family":"Pirinen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liliya","family":"Euro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saara","family":"Forsstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lotta","family":"Pasila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vidya","family":"Velagapudi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J","family":"Carroll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Auwerx","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anu","family":"Suomalainen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,4,7]]},"reference":[{"key":"BFEMMM201403943_CR1","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.1093\/hmg\/ddq076","volume":"19","author":"S Ahola\u2010Erkkila","year":"2010","unstructured":"Ahola\u2010Erkkila S, Carroll CJ, Peltola\u2010Mjosund K, Tulkki V, Mattila I, Seppanen\u2010Laakso T, Oresic M, Tyynismaa H, Suomalainen A (2010) Ketogenic diet slows down mitochondrial myopathy progression in mice. 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