{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:13:55Z","timestamp":1791994435316,"version":"4.4.0"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,5,3]],"date-time":"2023-05-03T00:00:00Z","timestamp":1683072000000},"content-version":"vor","delay-in-days":32,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP20H00527"],"award-info":[{"award-number":["JP20H00527"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP20K16597"],"award-info":[{"award-number":["JP20K16597"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epileptic Disorders"],"published-print":{"date-parts":[[2023,4]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n The neurofilament light chain (NfL) is receiving increased attention as a biomarker of neurological diseases, as NfL concentration elevated in the blood and cerebrospinal fluid after neuronal damage. However, few studies have addressed NfL in epilepsy. We aimed to investigate the alteration of serum NfL in adult patients with epilepsy, and the association between this biomarker and cognitive impairment.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n A total of 38 consecutive patients with epilepsy and 24 controls underwent cross\u2010sectional measurement of serum NfL levels and cognitive testing using the Mini\u2010Mental State Examination (MMSE), the Japanese version of the Montreal Cognitive Assessment (MoCA\u2010J), the Frontal Assessment Battery (FAB), the Trail\u2010Making Test, and the Stroop Color\u2013Word Test. Statistical analysis was performed with Student\u2019s\n t<\/jats:italic>\n \u2010test to compare serum NfL levels between the epilepsy group and the control group, and with Spearman\u2019s correlation and age\u2010corrected partial correlation analyses to evaluate the association between serum NfL level and cognitive impairment in epilepst patients.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n There was no difference in serum NfL levels between the epilepsy and control groups (epilepsy [mean\u2009\u00b1\u2009SD]: 17.3\u2009\u00b1\u200913.9\u2009pg\/mL; control: 17.7\u2009\u00b1\u200911.5 pg\/mL;\n p<\/jats:italic>\n \u2009=\u2009.92); however, the MoCA\u2010J scores were lower in the epilepsy group (26.6\u2009\u00b1\u20093.1 vs. 28.1\u2009\u00b1\u20091.6;\n p<\/jats:italic>\n \u2009=\u2009.03). The age\u2010corrected partial correlation analysis showed a correlation between serum NfL level and cognitive test scores in the epilepsy group (MMSE:\n r<\/jats:italic>\n \n s<\/jats:italic>\n <\/jats:sub>\n \u2009=\u2009\u2212.63,\n p<\/jats:italic>\n \u2009<\u2009.01; MoCA\u2010J:\n r<\/jats:italic>\n \n s<\/jats:italic>\n <\/jats:sub>\n \u2009=\u2009\u2212.54,\n p<\/jats:italic>\n \u2009<\u2009.01; FAB:\n r<\/jats:italic>\n \n s<\/jats:italic>\n <\/jats:sub>\n \u2009=\u2009\u2212.68,\n p<\/jats:italic>\n \u2009<\u2009.01), whereas serum NfL levels were correlated exclusively with MMSE scores in the control group (\n r<\/jats:italic>\n \n s<\/jats:italic>\n <\/jats:sub>\n \u2009=\u2009.44,\n p<\/jats:italic>\n \u2009=\u2009.04).\n <\/jats:p>\n <\/jats:sec>\n \n Significance<\/jats:title>\n In adult epilepsy patients, the serum NfL level was not significantly elevated, but was correlated with cognitive test scores. Our findings suggest that serum NfL concentration could be an indicator of cognitive function in epilepsy patients.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/epd2.20024","type":"journal-article","created":{"date-parts":[[2023,3,20]],"date-time":"2023-03-20T11:29:22Z","timestamp":1679311762000},"page":"229-236","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Serum neurofilament light chain in patients with epilepsy and cognitive impairment"],"prefix":"10.1002","volume":"25","author":[{"given":"Masamichi","family":"Ueda","sequence":"first","affiliation":[{"name":"Department of Neurology Nagoya University Graduate School of Medicine Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Neurology Nagoya University Graduate School of Medicine Nagoya Japan"},{"name":"Department of Clinical laboratory Nagoya University Hospital Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mai","family":"Hatanaka","sequence":"additional","affiliation":[{"name":"Department of Neurology Nagoya University Graduate School of Medicine Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiko","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Neurology Hamamatsu University School of Medicine Hamamatsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaaki","family":"Hirayama","sequence":"additional","affiliation":[{"name":"Department of Pathophysiological Laboratory Science Nagoya University Graduate School of Medicine Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9453-9311","authenticated-orcid":false,"given":"Masahisa","family":"Katsuno","sequence":"additional","affiliation":[{"name":"Department of Neurology Nagoya University Graduate School of Medicine Nagoya Japan"},{"name":"Department of Clinical Research Education Nagoya University Graduate School of Medicine Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5,3]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0013-9580.2005.66104.x"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.12550"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2014.02.012"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2017.08.007"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/epi4.12478"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/01616412.2020.1716468"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0920-1211(00)00126-1"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2017.03.011"},{"issue":"6","key":"e_1_2_10_10_1","first-page":"313","article-title":"Executive functions in adolescents with idiopathic generalized 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