{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T09:54:56Z","timestamp":1788602096863,"version":"build-2803163510"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,4,17]],"date-time":"2023-04-17T00:00:00Z","timestamp":1681689600000},"content-version":"vor","delay-in-days":75,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003407","name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epileptic Disorders"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate in a real clinical scenario the impact of the ILAE\u2010recommended \u201cHarmonized neuroimaging of epilepsy structural sequences\u201d\u2010 HARNESS protocol in patients affected by focal epilepsy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We prospectively enrolled focal epilepsy patients who underwent a structural brain MRI between 2020 and 2021 at Modena University Hospital. For all patients, MRIs were: (a) acquired according to the HARNESS\u2010MRI protocol (H\u2010MRI); (b) reviewed by the same neuroradiology team. MRI outcomes measures were: the number of positive (diagnostic) and negative MRI; the type of radiological diagnosis classified in: (1) Hippocampal Sclerosis; (2) Malformations of cortical development (MCD); (3) Vascular malformations; (4) Glial scars; (5) Low\u2010grade epilepsy\u2010associated tumors; (6) Dual pathology. For each patient we verified for previous MRI (without HARNESS protocol, noH\u2010MRI) and the presence of clinical information in the MRI request form. Then the measured outcomes were reviewed and compared as appropriate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 131 patients with H\u2010MRI were included in the study. 100 patients out from this cohort had at least one previous noH\u2010MRI scan. Of those, 92\/100 were acquired at the same Hospital than H\u2010MRI and 71\/92 on a 3T scanner. The HARNESS protocol revealed 81 (62%) positive and 50 (38%) negative MRI, and MCD was the most common diagnosis (60%). Among the entire pool of 100 noH\u2010MRI, 36 resulted positive with a significant difference (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) compared to H\u2010MRI. Similar findings were observed when accounting for the expert radiologists (H\u2010MRI\u2009=\u200957 positive; noH\u2010MRI\u2009=\u200933, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) and the scanner field strength (H\u2010MRI 43\u2009=\u2009positive, noH\u2010MRI\u2009=\u200923, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001), while clinical information were more present in H\u2010MRI (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.002).<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>The adoption of a standardized and optimized MRI acquisition protocol together with adequate clinical information contribute to identify a higher number of potentially epileptogenic lesions (especially FCD) thus impacting concretely on the clinical management of patients with focal epilepsy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/epd2.20050","type":"journal-article","created":{"date-parts":[[2023,3,22]],"date-time":"2023-03-22T10:29:21Z","timestamp":1679480961000},"page":"45-56","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Impact of an optimized epilepsy surgery imaging protocol for focal epilepsy: A monocentric prospective study"],"prefix":"10.1002","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6280-7526","authenticated-orcid":false,"given":"Anna Elisabetta","family":"Vaudano","sequence":"first","affiliation":[{"name":"Department of Biomedical, Metabolic and Neural Sciences University of Modena and Reggio Emilia  Modena Italy"},{"name":"Neurology Unit OCB Hospital, AOU Modena  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0544-1599","authenticated-orcid":false,"given":"Alice","family":"Ballerini","sequence":"additional","affiliation":[{"name":"Department of Biomedical, Metabolic and Neural Sciences University of Modena and Reggio Emilia  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Zucchini","sequence":"additional","affiliation":[{"name":"Neuroradiology Unit OCB Hospital, AOU Modena  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3991-3918","authenticated-orcid":false,"given":"Elisa","family":"Micalizzi","sequence":"additional","affiliation":[{"name":"Neurophysiology Unit IRCCS Ospedale Policlinico San Martino  Genova Italy"},{"name":"Clinical and Experimental Medicine PhD Program, Department of Biomedical, Metabolic and Neural Sciences University of Modena and Reggio Emilia  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3202-3429","authenticated-orcid":false,"given":"Simona","family":"Scolastico","sequence":"additional","affiliation":[{"name":"Department of Biomedical, Metabolic and Neural Sciences University of Modena and Reggio Emilia  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Talami","sequence":"additional","affiliation":[{"name":"Department of Biomedical, Metabolic and Neural Sciences University of Modena and Reggio Emilia  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3585-5872","authenticated-orcid":false,"given":"Giada","family":"Giovannini","sequence":"additional","affiliation":[{"name":"Neurology Unit OCB Hospital, AOU Modena  Modena Italy"},{"name":"Clinical and Experimental Medicine PhD Program, Department of Biomedical, Metabolic and Neural Sciences University of Modena 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