{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T19:52:41Z","timestamp":1778183561226,"version":"3.51.4"},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,4,25]],"date-time":"2023-04-25T00:00:00Z","timestamp":1682380800000},"content-version":"vor","delay-in-days":83,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epileptic Disorders"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Ictal clinical phenomenology, including aphasia, is usually associated with increased regional cerebral perfusion. We present an unusual pattern of ictal cerebral perfusion in three patients with pharmacoresistant, lesional temporal lobe epilepsy and ictal\/postictal aphasia studied with prolonged video\u2010EEG, ictal, and interictal SPECT and MRI for pre\u2010surgical evaluation. Subtraction of ictal\u2010interictal SPECT images co\u2010registered with MRI (SISCOM) showed ictal hyperperfusion in the temporal epileptogenic area in all patients. In addition, hypoperfusion of Broca's area in one case, Wernicke's area in other patient, and both areas in the remaining one were observed. Ictal aphasia in these patients may be explained by functional inhibition of a primary language area, driven by the epileptogenic network. This pattern can contribute to understand the pathophysiology of some ictal signs, with an impact on the evaluation of individual surgical risks.<\/jats:p>","DOI":"10.1002\/epd2.20061","type":"journal-article","created":{"date-parts":[[2023,4,18]],"date-time":"2023-04-18T08:16:28Z","timestamp":1681805788000},"page":"104-109","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Association of ictal aphasia with hypoperfusion in language areas in temporal lobe epilepsy patients"],"prefix":"10.1002","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5275-6067","authenticated-orcid":false,"given":"Andr\u00e9s","family":"Damian","sequence":"first","affiliation":[{"name":"Programa de Cirug\u00eda de Epilepsia, Hospital de Cl\u00ednicas, Facultad de Medicina Universidad de la Rep\u00fablica (UdelaR)  Montevideo Uruguay"},{"name":"Centro de Medicina Nuclear e Imagenolog\u00eda Molecular Hospital de Cl\u00ednicas  Montevideo Uruguay"},{"name":"Centro Uruguayo de Imagenolog\u00eda Molecular (CUDIM)  Montevideo Uruguay"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4695-4577","authenticated-orcid":false,"given":"Mariana","family":"Legnani","sequence":"additional","affiliation":[{"name":"Programa de Cirug\u00eda de Epilepsia, Hospital de Cl\u00ednicas, Facultad de Medicina Universidad de la Rep\u00fablica (UdelaR)  Montevideo Uruguay"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7928-375X","authenticated-orcid":false,"given":"Patricia","family":"Braga","sequence":"additional","affiliation":[{"name":"Programa de Cirug\u00eda de Epilepsia, Hospital de Cl\u00ednicas, Facultad de Medicina Universidad de la Rep\u00fablica (UdelaR)  Montevideo 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